Hedgehog morphogen: from secretion to reception

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Hedgehog: functions and mechanisms

2008 • 1,190 citations

Hedgehog Signaling in Development and Cancer

2008 • 1,013 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Functions of heparan sulfate proteoglycans in cell signaling during development

2004 • 659 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Cytonemes

1999 • 602 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

Cell Polarity in Eggs and Epithelia: Parallels and Diversity

2010 • 465 citations

Sorting GPI-anchored proteins

2004 • 415 citations

The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice

2006 • 383 citations

A Wnt Survival Guide: From Flies to Human Disease

2009 • 363 citations

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

2004 • 360 citations

Shaping Morphogen Gradients by Proteoglycans

2009 • 338 citations

The Molecular Diversity of Glycosaminoglycans Shapes Animal Development

2006 • 335 citations

Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding

2008 • 330 citations

Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched

2002 • 327 citations

Positional information revisited

1989 • 322 citations

Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila Raft Lipid Microdomains

1999 • 320 citations

Novel Lipid Modifications of Secreted Protein Signals

2004 • 319 citations

The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans

2006 • 292 citations

Boc is a receptor for sonic hedgehog in the guidance of commissural axons

2006 • 289 citations

The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides

2001 • 288 citations

The sterol-sensing domain: multiple families, a unique role?

2002 • 286 citations

Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway

2009 • 271 citations

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

2008 • 239 citations

Cytonemes and tunneling nanotubules in cell–cell communication and viral pathogenesis

2008 • 232 citations

The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation

2006 • 230 citations

Drosophilaglypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc

2005 • 216 citations

Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic

2005 • 205 citations

Interactions between Hedgehog proteins and their binding partners come into view

2010 • 204 citations

The GPI-anchor and protein sorting

2001 • 194 citations

Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling

2002 • 185 citations

Cholesterol modification restricts the spread of Shh gradient in the limb bud

2006 • 182 citations

Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog

2003 • 180 citations

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

2002 • 179 citations

Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface

2008 • 173 citations

Lipoprotein-Heparan Sulfate Interactions in the Hh Pathway

2007 • 166 citations

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

2008 • 158 citations

Cerebellar proteoglycans regulate sonic hedgehog responses during development

2002 • 155 citations

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis

2008 • 155 citations

Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog inDrosophilaepithelia

2006 • 148 citations

BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation

2002 • 143 citations

Fetal alcohol exposure impairs hedgehog cholesterol modification and signaling

2007 • 142 citations

Nanoscale Organization of Hedgehog Is Essential for Long-Range Signaling

2008 • 142 citations

The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane

2001 • 139 citations

Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

2006 • 139 citations

The shedding activity of ADAM17 is sequestered in lipid rafts

2006 • 137 citations

Multiple roles for lipids in the Hedgehog signalling pathway

2008 • 134 citations

The Drosophila Ortholog of the Human Wnt Inhibitor Factor Shifted Controls the Diffusion of Lipid-Modified Hedgehog

2005 • 124 citations

Genetic and biochemical definition of the Hedgehog receptor

2010 • 123 citations

Shifted, the Drosophila Ortholog of Wnt Inhibitory Factor-1, Controls the Distribution and Movement of Hedgehog

2005 • 120 citations

Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells

2009 • 116 citations

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

2010 • 115 citations

Ventral Neural Progenitors Switch toward an Oligodendroglial Fate in Response to Increased Sonic Hedgehog (Shh) Activity: Involvement of Sulfatase 1 in Modulating Shh Signaling in the Ventral Spinal Cord

2006 • 113 citations

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

2008 • 113 citations

Scube2 mediates Hedgehog signalling in the zebrafish embryo

2006 • 112 citations

The hedgehog gene family in Drosophila and vertebrate development

1994 • 109 citations

Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand

2004 • 108 citations

The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development

2010 • 108 citations

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum

2010 • 106 citations

The you Gene Encodes an EGF-CUB Protein Essential for Hedgehog Signaling in Zebrafish

2005 • 106 citations

Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo

2004 • 98 citations

Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling

2010 • 97 citations

The role of glypican-3 in the regulation of body size and cancer

2008 • 92 citations

Patched, the receptor of Hedgehog, is a lipoprotein receptor

2008 • 92 citations

CDO, A Robo-related Cell Surface Protein that Mediates Myogenic Differentiation

1998 • 91 citations

Structure of a heparin-dependent complex of Hedgehog and Ihog

2006 • 90 citations

Patched regulates Smoothened trafficking using lipoprotein-derived lipids

2009 • 90 citations

Chapter 4 The Biology of Caveolae

2009 • 86 citations

Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response

2010 • 82 citations

A conserved mechanism of Hedgehog gradient formation by lipid modifications

2006 • 80 citations

CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells

2000 • 78 citations

Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids

2004 • 76 citations

Lipoproteins and their receptors in embryonic development: more than cholesterol clearance

2007 • 75 citations

Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

2009 • 75 citations

Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans

2009 • 66 citations

Evidence for a role of vertebrate Disp1 in long-range Shh signaling

2009 • 66 citations

Release and trafficking of lipid-linked morphogens

2005 • 66 citations

Differential range and activity of various forms of the Hedgehog protein

2005 • 64 citations

Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord

2007 • 63 citations

Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog

2005 • 60 citations

The role of kinases in the Hedgehog signalling pathway

2008 • 57 citations

Human Plasma Very Low Density Lipoprotein Carries Indian Hedgehog

2010 • 48 citations

Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?

2009 • 40 citations

Lipid-modified morphogens: functions of fats

2009 • 40 citations

Heparan Sulfate and Transglutaminase Activity Are Required for the Formation of Covalently Cross-linked Hedgehog Oligomers

2009 • 40 citations

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

2009 • 37 citations

New developments in the discovery of small molecule Hedgehog pathway antagonists

2010 • 34 citations

Les déplacés. Travail sur soi et ascension sociale : la promotion littéraire de Jules Romains

1996 • 33 citations

Secretion of Hedgehog‐Related Peptides and WNT During Caenorhabditis elegans Development

2009 • 27 citations