Effects of Ionizing Radiation in Targeted and Nontargeted Cells

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Catalog of chromosome aberrations in cancer

1985 • 1,522 citations

DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability

1988 • 1,434 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA

1994 • 1,142 citations

Cell Proliferation in Carcinogenesis

1990 • 1,063 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Induction of sister chromatid exchanges by extremely low doses of alpha-particles.

1992 • 979 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Radiation Biology in Cancer Research

1980 • 782 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Changes in Bronchial Epithelium in Relation to Cigarette Smoking and in Relation to Lung Cancer

1961 • 625 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

The Complexity of DNA Damage: Relevance to Biological Consequences

1994 • 604 citations

Transmission of chromosomal instability after plutonium α-particle irradiation

1992 • 603 citations

Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells

1997 • 592 citations

Radon and its decay products in indoor air

1988 • 541 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles

1998 • 509 citations

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

1997 • 489 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.

1997 • 445 citations

Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells

1999 • 436 citations

Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells

1999 • 427 citations

Mechanisms of chemical carcinogenesis

1981 • 424 citations

Cell-Cell Contact during Gamma Irradiation Is Not Required to Induce a Bystander Effect in Normal Human Keratinocytes: Evidence for Release during Irradiation of a Signal Controlling Survival into the Medium

1998 • 423 citations

Studies of bystander effects in human fibroblasts using a charged particle microbeam

1998 • 410 citations

Catalog of Chromosome Aberrations in Cancer

1992 • 405 citations

Transforming growth factor-beta: a general review.

1996 • 400 citations

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

1993 • 394 citations

Sister Chromatid Exchange

1983 • 387 citations

Ataxia-telangiectasia and cellular responses to DNA damage.

1995 • 378 citations

Lung Cancer in Radon-Exposed Miners and Estimation of Risk From Indoor Exposure

1995 • 378 citations

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

1995 • 351 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

Initiation of chemical carcinogenesis requires cell proliferation

1978 • 345 citations

Radiation biology in cancer research

1978 • 340 citations

DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis.

1993 • 334 citations

The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells

1991 • 330 citations

The Role of DNA Single- and Double-Strand Breaks in Cell Killing by Ionizing Radiation

1998 • 322 citations

Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis

1994 • 321 citations

Sister chromatid exchanges induced in chinese hamster cells by UV irradiation of different stages of the cell cycle: The necessity for cells to pass through S

1974 • 312 citations

Chromosomal instability in the descendants of unirradiated surviving cells after α-particle irradiation

1998 • 303 citations

The Response of Chinese Hamster V79 Cells to Low Radiation Doses: Evidence of Enhanced Sensitivity of the Whole Cell Population

1993 • 293 citations

Alpha-Particle-Induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an Extranuclear Target

1996 • 286 citations

Molecular mechanisms involved in the production of cromosomal aberrations II. Utilization of neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle

1980 • 280 citations

Second cancers following pediatric Hodgkin's disease.

1998 • 274 citations

Unexpected Sensitivity to the Induction of Mutations by Very Low Doses of Alpha-Particle Radiation: Evidence for a Bystander Effect

1999 • 265 citations

Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells.

1997 • 264 citations

Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures

1996 • 263 citations

Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils

1989 • 260 citations

Low levels of reactive oxygen species as modulators of cell function

1995 • 250 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

Cellular Radiation Biology

1965 • 234 citations

Mutagenic effects of a single and an exact number of α particles in mammalian cells

1997 • 234 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Spontaneous and Induced Sister Chromatid Exchanges as Revealed by the BUdR-Labeling Method

1977 • 220 citations

α-particle-induced chromosomal instability in human bone marrow cells

1994 • 200 citations

DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. II. Can Cell Death be Attributed to Double Strand Breaks?

1982 • 200 citations

The Relative Radiosensitivity of the Nucleus and Cytoplasm of Chinese Hamster Fibroblasts

1970 • 183 citations

Genomic Instability and Tumor Progression: Mechanistic Considerations

1992 • 178 citations

The oncogenic transforming potential of the passage of single α particles through mammalian cell nuclei

1999 • 173 citations

Reactive oxygen species and silica‐induced carcinogenesis

1998 • 170 citations

Cellular Radiation Biology

1974 • 170 citations

UV-induced extracellular factor from human fibroblasts communicates the UV response to nonirradiated cells

1984 • 162 citations

Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain.

1994 • 161 citations

Radiobiology of α Particles: III. Cell Inactivation by α-Particle Traversals of the Cell Nucleus

1991 • 161 citations

Cell Renewal in the Lungs of Rats Exposed to Low Levels of NO₂

1972 • 158 citations

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

1997 • 153 citations

Chromosome Damage Induced by Plasma of X-Rayed Patients: An Indirect Effect of X-Ray

1968 • 152 citations

Organochlorine pesticide-induced oxidative stress and immune suppression in rats.

1998 • 136 citations

Measurement of mutagenesis in mammalian cells.

1979 • 136 citations

Breaks in Normal Human Chromosomes: Are They Induced by a Transferable Substance in the Plasma of Persons Exposed to Total-Body Irradiation?

1968 • 132 citations

Radiotoxicity of Intracellular⁶⁷Ga,¹²⁵I and³H

1975 • 129 citations

Evidence for Pronounced Bystander Effects Caused by Nonuniform Distributions of Radioactivity using a Novel Three-Dimensional Tissue Culture Model

1999 • 126 citations

Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multilocus lesions.

1986 • 122 citations

Differential induction of chromosomal instability by DNA strand-breaking agents.

1997 • 121 citations

Ionizing Radiation-induced Cell Death

1994 • 119 citations

Oxidative stress is involved in the UV activation of p53

1996 • 114 citations

Clastogenic activity from Bloom syndrome fibroblast cultures.

1981 • 114 citations

Redox‐Mediated Regulation of p21^Waf1/Cip1 Expression Involves a Post‐Transcriptional Mechanism and Activation of the Mitogen‐Activated Protein Kinase Pathway

1997 • 112 citations

Clastogenic Factors in the Plasma of Chernobyl Accident Recovery Workers: Anticlastogenic Effect of Ginkgo biloba Extract

1995 • 111 citations

Caffeine Enhancement of X-Ray Killing in Cultured Human and Rodent Cells

1978 • 103 citations

Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA

1997 • 95 citations

Hydrogen Peroxide and the Proliferation of Bhk-21 Cells

1995 • 92 citations

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2

1996 • 89 citations

Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.

1997 • 78 citations

Antioxidant Regulation of Phorbol Ester-Induced Adhesion of Human Jurkat T-Cells to Endothelial Cells

1998 • 76 citations

Radiation-induced clastogenic plasma factors

1984 • 74 citations

Cloning and characterization of Chinese hamster p53 cDNA

1997 • 72 citations

Endogenously Generated Active Oxygen Species and Cellular Glutathione Levels in Relation to BHK-21 Cell Proliferation

1994 • 65 citations

Cancer Predisposition, Radiosensitivity and the Risk of Radiation-Induced Cancers. I. Background

1995 • 63 citations

A diffusable clastogenic factor in ataxia telangiectasia

1980 • 60 citations

Activation of the NADPH oxidase in human fibroblasts by mechanical intrusion of a single cell with an ultramicroelectrode

1997 • 57 citations

Clastogenic inosine nucleotide as components of the chromosome breakage factor in scleroderma patients

1990 • 57 citations

HSP binding and mitochondrial localization of p53 protein in human HT1080 and mouse C3H10T1/2 cell lines

1996 • 55 citations

Alterations in the Progression of Cells through the Cell Cycle after Exposure to Alpha Particles or Gamma Rays

1996 • 54 citations

THE EFFECT OF IRRADIATED PLASMA ON NORMAL HUMAN CHROMOSOMES AND ITS RELEVANCE TO THE LONG‐LIVED LYMPHOCYTE HYPOTHESIS

1969 • 50 citations

Second malignant neoplasms in children after treatment of soft tissue sarcoma

1997 • 50 citations

Molecular Mechanisms of Radiation Oncogenesis

1994 • 48 citations

Mechanisms of Chemical Carcinogenesis

1983 • 46 citations

Plasmin cleaves betaglycan and releases a 60 kDa transforming growth factor-β complex from the cell surface

1994 • 45 citations

Gap Junction Intercellular Communication Mediates the Competitive Cell Proliferation Disadvantage of Irradiated Mouse Preimplantation Embryos in Aggregation Chimeras

1999 • 44 citations

The relationship between the cell time available for repair and the effectiveness of a damaging treatment in provoking the formation of sister-chromatid exchanges

1980 • 43 citations

EPA’s Perspective on Risks from Residential Radon Exposure

1989 • 40 citations

Research uses of the gamma field and related radiation facilities at Brookhaven national laboratory

1966 • 39 citations

Liver microsomal parameters related to oxidative stress and antioxidant systems in hyperthyroid rats subjected to acute lindane treatment

1998 • 34 citations

Cytotoxicity of hexachlorocyclohexane isomers and cyclodienes in primary cultures of cerebellar granule cells.

1996 • 34 citations

A DNA repair defect in a radiation-sensitive clone of a human bladder carcinoma cell line

1992 • 29 citations

Changes in the Rat Lung after Exposure to Radon and Its Progeny: Effects on Incorporation of Bromodeoxyuridine in Epithelial Cells and on the Incidence of Nuclear Aberrations in Alveolar Macrophages

1994 • 29 citations

The 1987 Walter Hubert lecture: Regulation and deficiencies in DNA repair

1987 • 29 citations

EFFECT OF RADON ON THE IMMUNE SYSTEM: ALTERATIONS IN THE CELLULARITY AND FUNCTIONS OF T CELLS IN LYMPHOID ORGANS OF MOUSE

1996 • 27 citations

Enhanced Neoplastic Transformation in an Inhomogeneous Radiation Field: An Effect of the Presence of Heavily Damaged Cells

1997 • 27 citations

The nucleus is the target for radiation-induced chromosomal instability.

1998 • 25 citations

The Nucleus Is the Target for Radiation-Induced Chromosomal Instability

1998 • 23 citations

III. Inactivation of Bacteriophage After Irradiation

1954 • 23 citations

The Microdosimetry of Radon Decay Products in the Respiratory Tract

1990 • 22 citations

The Genetic Basis of Cellular Recovery from Radiation Damage: Response of the Radiosensitive irs Lines to Low-Dose-Rate Irradiation

1995 • 16 citations

Short-Term Effects of Sidestream Smoke on Respiratory Epithelium in Mice: Cell Kinetics

1994 • 16 citations

Carcinogenic Risk of Non-Uniform Alpha Particle Irradiation in the Lungs: Radon Progeny Effects at Bronchial Bifurcations

1991 • 15 citations

Caffeine enhanced measurement of mutagenesis by low levels of ?-irradiation in human lymphocytes

1993 • 14 citations

Protein Kinase C- and Ca2+ Ionophore-Stimulated Production of Reactive Oxygen Species in Mechanically Dispersed Isolated Bovine Luteal Cells1

1997 • 13 citations

Cytotoxic and cell transforming effects of the insecticide, lindane (gamma-hexachlorocyclohexane) on BALB/c 3T3 cells.

1995 • 13 citations

Model for Assessing Radiation Dose to Epithelial Cells of the Human Respiratory Tract from Radon Progeny

1991 • 11 citations

Radon and its decay products in indoor air

1988 • 10 citations

Modulation by novobiocin of sister-chromatid exchanges induced by tumor necrosis factor in human lymphocytes

1992 • 10 citations

Increasing radiosensitivity in the course of fractionated X irradiation: the effect of contact with dead and dying cells.

1998 • 10 citations

Increasing Radiosensitivity in the Course of Fractionated X Irradiation: The Effect of Contact with Dead and Dying Cells

1998 • 9 citations

The UVA Light Used during the Fluorescence Microscopy Assay Affects the Level of Intracellular Calcium Being Measured in Experiments with Electric-Field Exposure

1999 • 9 citations

Assay of free-radical toxicity and antioxidant effect on the Hep 3B cell line: a test survey using lindane

1996 • 8 citations

Alpha irradiation of parts of single cells in tissue cultures

1958 • 5 citations

Clastogenic Factors as Biomarkers of Oxidative Stress

1998 • 2 citations