Alterations in the Progression of Cells through the Cell Cycle after Exposure to Alpha Particles or Gamma Rays

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Free Radicals in Biology: Oxidative Stress and the Effects of Ionizing Radiation

1994 • 1,396 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1992 • 638 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

The Complexity of DNA Damage: Relevance to Biological Consequences

1994 • 604 citations

Variations in Several Responses of HeLa Cells to X-Irradiation during the Division Cycle

1963 • 592 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

Cell and tissue responses to oxidative damage.

1993 • 492 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

Interaction of lipid peroxidation products with DNA. A review

1988 • 455 citations

High-LET radiations induce a large proportion of non-rejoining DNA breaks

1977 • 360 citations

Possible mutagens derived from lipids and lipid precursors

1990 • 340 citations

Alpha-Particle-Induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an Extranuclear Target

1996 • 286 citations

Evidence for DNA Double-Strand Breaks as the Critical Lesions in Yeast Cells Irradiated with Sparsely or Densely Ionizing Radiation under Oxic or Anoxic Conditions

1981 • 271 citations

The Initial Physical Damage Produced by Ionizing Radiations

1989 • 255 citations

Ceramide: A stress signal and mediator of growth suppression and apoptosis

1995 • 233 citations

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

1995 • 226 citations

Mediator‐induced activation of xanthine oxidase in endothelial cells

1989 • 223 citations

Effects of Caffeine on Radiation-Induced Phenomena Associated with Cell-Cycle Traverse of Mammalian Cells

1974 • 191 citations

Induction and Rejoining of DNA Double-strand Breaks in V79-4 Mammalian Cells Following γ- and α-irradiation

1993 • 186 citations

DNA Double-strand Break Repair Determines the RBE of α-particles

1988 • 172 citations

Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain.

1994 • 161 citations

Radiobiology of α Particles: III. Cell Inactivation by α-Particle Traversals of the Cell Nucleus

1991 • 161 citations

Mitochondrial production of pro-oxidants and cellular senescence

1992 • 137 citations

Oxidative and other DNA damages as the basis of aging: a review

1992 • 135 citations

Drastic G 2 Arrest in Mammalian Cells after Irradiation with Heavy-Ion Beams

1979 • 108 citations

The Formation of Strand Breaks in DNA after High-LET Irradiation: A Comparison of Data fromin Vitroand Cellular Systems

1990 • 96 citations

Radiobiology of Ultrasoft X Rays: I. Cultured Hamster Cells (V79)

1987 • 96 citations

Dual‐laser, differential fluorescence correction method for reducing cellular background autofluorescence

1986 • 93 citations

Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells

1980 • 80 citations

Estimating Rn-induced Lung Cancer in the United States

1989 • 79 citations

Effect of Radiation Quality on Lesion Complexity in Cellular DNA

1994 • 77 citations

Radiation-induced cycle delay in synchronized Chinese hamster cells: comparison between DNA synthesis and division.

1973 • 76 citations

Relationship of radioactive radon daughters and cigarette smoking in the genesis of lung cancer in uranium miners

1988 • 66 citations

Cell Cycle Delays Induced by Heavy Ion Irradiation of Synchronous Mammalian Cells

1994 • 66 citations

Lipid peroxidation and mtDNA degeneration. A hypothesis

1992 • 66 citations

Three‐color fluorescence measurements on single cells excited at three laser wavelengths

1982 • 65 citations

Interaction of DNA and liposomes as a model for membrane-mediated DNA damage

1977 • 64 citations

A new method for rapid and sensitive detection of bromodeoxyuridine in DNA-replicating cells

1987 • 62 citations

Use of Radiation Quality as a Probe for DNA Lesion Complexity

1994 • 61 citations

The Combined Effects of α-particles and X-rays on Cell Killing and Micronuclei Induction in Lung Epithelial Cells

1990 • 52 citations

Repair of Potentially Lethal Damage in Chinese Hamster Cells after X and α Irradiation

1977 • 48 citations

Southern Blot and Polymerase Chain Reaction Exon Analyses of HPRT - Mutations Induced by Radon and Radon Progeny

1994 • 47 citations

Structural Changes in Plasma Membranes Prepared from Irradiated Chinese Hamster V79 Cells as Revealed by Raman Spectroscopy

1991 • 47 citations

Radiobiology of α Particles: I. Exposure System and Dosimetry

1990 • 43 citations

EPA’s Perspective on Risks from Residential Radon Exposure

1989 • 40 citations

The effect of X irradiation on the progression of mouse 10T1/2 cells released from density-inhibited cultures.

1984 • 31 citations

Differences in Cell-Cycle Progression Delays after Exposure to 238 Pu a Particles Compared to X Rays

1980 • 26 citations

G2‐delay after irradiation with α‐particles as studied in synchronized cultures and by the bromodeoxyuridine‐33258H technique

1981 • 15 citations