Cyclin-dependent kinase and initiation at eukaryotic origins: a replication switch?

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

1992 • 1,279 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.

1993 • 521 citations

ANIMAL VIRUS DNA REPLICATION

1989 • 520 citations

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle

1994 • 478 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a ‘reductional’ anaphase in the budding yeast Saccharomyces cerevisiae.

1995 • 402 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts

1996 • 387 citations

At the heart of the budding yeast cell cycle

1996 • 367 citations

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

1995 • 366 citations

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

1996 • 362 citations

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

1995 • 357 citations

Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

1994 • 356 citations

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

1991 • 340 citations

The Role of p34 Kinases in the G1 to S-Phase Transition

1992 • 313 citations

Sequential function of gene products relative to DNA synthesis in the yeast cell cycle

1976 • 302 citations

Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.

1996 • 293 citations

A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.

1996 • 285 citations

A quantitative model for the cdc2 control of S phase and mitosis in fission yeast

1996 • 267 citations

p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast

1995 • 259 citations

The multidomain structure of Orc1 p reveals similarity to regulators of DNA replication and transcriptional silencing

1995 • 259 citations

Cell Cycle Control

1995 • 259 citations

Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus

1996 • 255 citations

Cell Cycle Regulation of the Yeast Cdc7 Protein Kinase by Association With the Dbf4 Protein†

1993 • 250 citations

Point of No Return

1949 • 247 citations

Conserved Initiator Proteins in Eukaryotes

1995 • 246 citations

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication

1989 • 242 citations

Linkage of Replication to Start by the Cdk Inhibitor Sic1

1996 • 230 citations

Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.

1995 • 220 citations

Interaction of Dbf4, the Cdc7 Protein Kinase Regulatory Subunit, with Yeast Replication Origins in Vivo

1994 • 213 citations

Role for a Xenopus Orc2-related protein in controlling DNA replication

1996 • 207 citations

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase

1995 • 190 citations

hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication.

1995 • 152 citations

A Drosophila Homolog of the Yeast Origin Recognition Complex

1995 • 152 citations

The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start.

1996 • 151 citations

A human protein related to yeast Cdc6p

1997 • 147 citations

Interaction of Cdc2 and CdclS with a fission yeast ORC2-like protein

1996 • 131 citations

cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 129 citations

Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.

1996 • 126 citations

Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity

1988 • 125 citations

Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases.

1996 • 121 citations

B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor.

1996 • 115 citations

Cig2, a B-Type Cyclin, Promotes the Onset of S in Schizosaccharomyces pombe

1996 • 114 citations

The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.

1996 • 113 citations

Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.

1995 • 98 citations

Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 96 citations

A B-type cyclin negatively regulates conjugation via interacting with cell cycle ‘start’ genes in fission yeast.

1994 • 92 citations

Replication protein A mutants lacking phosphorylation sites for p34cdc2 kinase support DNA replication.

1994 • 80 citations

Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle.

1994 • 80 citations

Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle.

1993 • 73 citations

Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding

1993 • 72 citations

Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.

1992 • 72 citations

Phosphorylation of DNA polymerase α-primase by Cyclin A-dependent kinases regulates initiation of DNA replication in vitro

1997 • 68 citations

Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis.

1993 • 62 citations

cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen

1993 • 62 citations

Molecular Cloning of Saccharomyces cerevisiae CDC6 Gene

1989 • 60 citations

Qualifying for the license to replicate

1995 • 59 citations

Interaction of the S phase regulator Cdc18 with cyclin-dependent kinase in fission yeast

1997 • 45 citations

Initiation of SV40 DNA Replication: Mechanism and Control

1991 • 35 citations

Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle

1994 • 30 citations

Introduction to cell cycle controls

1995 • 4 citations

Two Fission Yeast B-Type Cyclins, Cig2 and Cdc13, Have Different Functions in Mitosis

1994 • 2 citations