The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.

[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

1991 • 3,691 citations

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

1992 • 1,279 citations

Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe

1976 • 906 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

The NDA3 gene of fission yeast encodes β-tubulin: A cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis

1984 • 473 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

1993 • 435 citations

MUTANTS OF S. CEREVISIAE DEFECTIVE IN THE MAINTENANCE OF MINICHROMOSOMES

1984 • 419 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

Protein-DNA interactions at a yeast replication origin

1992 • 380 citations

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

1996 • 362 citations

Purification of an MCM-containing complex as a component of the DNA replication licensing system

1995 • 361 citations

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

1995 • 357 citations

Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

1994 • 356 citations

Origin Recognition Complex (ORC) in Transcriptional Silencing and DNA Replication in S. cerevisiae

1993 • 314 citations

Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe

1981 • 309 citations

Identification of the yeast MCM3-related protein as a component of xenopus DNA replication licensing factor

1995 • 280 citations

Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast

1990 • 266 citations

The multidomain structure of Orc1 p reveals similarity to regulators of DNA replication and transcriptional silencing

1995 • 259 citations

p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast

1995 • 259 citations

Conserved Initiator Proteins in Eukaryotes

1995 • 246 citations

Versatile shuttle vectors and genomic libraries for use with Schizosaccharomyces pombe

1992 • 241 citations

BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication.

1995 • 234 citations

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.

1993 • 233 citations

Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdclO+

1992 • 233 citations

cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.

1994 • 232 citations

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing

1993 • 231 citations

Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+

1993 • 231 citations

Subcellular localization of yeast CDC46 varies with the cell cycle.

1990 • 226 citations

Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis.

1988 • 210 citations

Epistatic gene interactions in the control of division in fission yeast

1979 • 208 citations

Role for a Xenopus Orc2-related protein in controlling DNA replication

1996 • 207 citations

The origin recognition complex in silencing, cell cycle progression, and DNA replication.

1995 • 204 citations

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase

1995 • 190 citations

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.

1995 • 187 citations

DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.

1994 • 173 citations

A Drosophila Homolog of the Yeast Origin Recognition Complex

1995 • 152 citations

Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication

1996 • 151 citations

Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae.

1992 • 145 citations

Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast.

1995 • 140 citations

Fission yeastcdc21⁺belongs to a family of proteins involved in an early step of chromosome replication

1992 • 131 citations

Interaction of Cdc2 and CdclS with a fission yeast ORC2-like protein

1996 • 131 citations

cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 129 citations

Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts.

1994 • 124 citations

A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products.

1992 • 122 citations

The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts

1995 • 119 citations

DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast

1995 • 118 citations

B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor.

1996 • 115 citations

Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation

1993 • 114 citations

Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.

1996 • 112 citations

Regulating S Phase: CDKs, Licensing and Proteolysis

1996 • 109 citations

Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.

1995 • 98 citations

Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle.

1996 • 98 citations

Chromotin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.

1996 • 86 citations

hCDC47, a Human Member of the MCM Family

1996 • 80 citations

A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.

1995 • 55 citations

Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe

1992 • 42 citations

The role of MCM/P1 proteins in the licensing of DNA replication

1996 • 18 citations