Activation of RalA is critical for Ras-induced tumorigenesis of human cells

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Stable suppression of tumorigenicity by virus-mediated RNA interference

2002 • 1,147 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Understanding Ras: ‘it ain’t over ’til it’s over’

2000 • 785 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Species- and cell type-specific requirements for cellular transformation

2004 • 542 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

The small GTPase RalA targets filamin to induce filopodia

1999 • 449 citations

The exocyst is a Ral effector complex

2001 • 426 citations

Distinct requirements for Ras oncogenesis in human versus mouse cells

2002 • 425 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Genetic profile of 22 pancreatic carcinoma cell lines

2001 • 323 citations

Identification and Characterization of Ral-Binding Protein 1, a Potential Downstream Target of Ral GTPases

1995 • 304 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma.

1980 • 242 citations

Ral GTPases Regulate Exocyst Assembly through Dual Subunit Interactions

2003 • 240 citations

BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer

2003 • 235 citations

Comparative analysis of mutations in the p53 and K‐ras genes in pancreatic cancer

1994 • 235 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

2003 • 201 citations

RAL GTPases are linchpin modulators of human tumour‐cell proliferation and survival

2003 • 187 citations

p53 and K-RAS alterations in pancreatic epithelial cell lesions.

1993 • 186 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways

2001 • 157 citations

Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression.

2002 • 155 citations

RalA but Not RalB Enhances Polarized Delivery of Membrane Proteins to the Basolateral Surface of Epithelial Cells

2004 • 146 citations

Activation of the Small GTPase Ral in Platelets

1998 • 144 citations

β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization

2002 • 137 citations

The Nucleolar Localization Domain of the Catalytic Subunit of Human Telomerase

2002 • 134 citations

An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity

2000 • 125 citations

Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080.

1984 • 124 citations

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

1996 • 121 citations

Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase

2001 • 117 citations

Ras-dependent activation of the small GTPase Ral

1998 • 112 citations

Ral GTPases Contribute to Regulation of Cyclin D1 through Activation of NF-κB

2000 • 105 citations

p21 with a phenylalanine 28—-leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties.

1991 • 102 citations

Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts

2000 • 100 citations

RalA Interacts Directly with the Arf-Responsive, PIP2-Dependent Phospholipase D1

1997 • 97 citations

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

1999 • 89 citations

Ras Mediates the Activation of Phospholipase D by v-Src

1995 • 87 citations

The role of Ral A in epidermal growth factor receptor-regulated cell motility.

2002 • 81 citations

Ras-Dependent Regulation of c-Jun Phosphorylation Is Mediated by the Ral Guanine Nucleotide Exchange Factor-Ral Pathway

2000 • 78 citations

A Novel Strategy for Specifically Down-regulating Individual Rho GTPase Activity in Tumor Cells

2003 • 74 citations

PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism

2002 • 72 citations

EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation

2003 • 69 citations

Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

1997 • 67 citations

Characterization of a GTPase-activating protein for the Ras-related Ral protein

1991 • 63 citations

RalA Activation at Nascent Lamellipodia of Epidermal Growth Factor-stimulated Cos7 Cells and Migrating Madin-Darby Canine Kidney Cells

2004 • 58 citations

Guanine nucleotide binding properties of the mammalian RalA protein produced in Escherichia coli.

1990 • 53 citations

A Genetically Defined Normal Human Somatic Cell System to Study Ras Oncogenesis In Vivo and In Vitro

2006 • 53 citations

Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells

2004 • 45 citations

RhoB, Not RhoA, Represses the Transcription of the Transforming Growth Factor β Type II Receptor by a Mechanism Involving Activator Protein 1

2002 • 43 citations

Ras Signaling, Deregulation of Gene Expression and Oncogenesis

2006 • 33 citations

Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells

2001 • 23 citations

Ral Promotes Anchorage-Independent Growth of a Human Fibrosarcoma, HT10801

2001 • 18 citations

Detection of ras oncogenes by analysis of p21 proteins in human tumor cell lines

1988 • 4 citations