Comparative analysis of mutations in the p53 and K‐ras genes in pancreatic cancer

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

p53 function and dysfunction

1992 • 1,918 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.

1992 • 500 citations

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer

1991 • 375 citations

Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.

1993 • 351 citations

High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas

1989 • 295 citations

Ki-ras oncogene activation in preinvasive pancreatic cancer

1992 • 250 citations

p53 and K-RAS alterations in pancreatic epithelial cell lesions.

1993 • 186 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.

1992 • 171 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.

1992 • 146 citations

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

1984 • 132 citations

K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.

1992 • 123 citations

c‐Ki‐rasPoint Mutations in Ductectatic‐type Mucinous Cystic Neoplasms of the Pancreas

1991 • 122 citations

Allelic loss on chromosome 17p and p53 mutations in human endometrial carcinoma of the uterus.

1991 • 118 citations

The p53 cellular tumor antigen: gene structure, expression and protein properties

1985 • 108 citations

Oncogene detection at the single cell level.

1988 • 89 citations

Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes.

1986 • 37 citations

MUTATIONS IN THE P53 SUPPRESSOR GENE DO NOT CORRELATE WITH C-K-RAS ONCOGENE MUTATIONS IN COLORECTAL-CANCER

1993 • 25 citations