Hippocampal Myc and p53 expression following transient global ischemia

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system

1988 • 1,235 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Selective vulnerability of the hippocampus in brain ischemia

1991 • 876 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

The MYC protein activates transcription of the alpha-prothymosin gene.

1991 • 589 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

p53 expression in nitric oxide‐induced apoptosis

1994 • 403 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

p53 in signaling checkpoint arrest or apoptosis

1996 • 336 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

Selective neuron loss after cerebral ischemia in the rat: Possible role of transmitter glutamate

2009 • 305 citations

Myc oncoproteins are phosphorylated by casein kinase II.

1989 • 287 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation.

1988 • 253 citations

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM

1995 • 253 citations

Evidence for p53-Mediated Modulation of Neuronal Viability

1996 • 247 citations

The role of free radicals and p53 in neuron apoptosis in vivo

1995 • 239 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?

1993 • 215 citations

Endonuclease activation following focal ischemic injury in the rat brain

1993 • 211 citations

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.

1994 • 210 citations

p53 Plays a Regulatory Role in Differentiation and Apoptosis of Central Nervous System-Associated Cells

1996 • 199 citations

Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain

1994 • 197 citations

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

1994 • 183 citations

In situ hybridization analysis of c-fos and c-jun expression in the rat brain following transient forebrain ischemia

1991 • 180 citations

p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

1997 • 169 citations

Selective Vulnerability of the Hippocampus to Ischemia — Reversible and Irreversible Types of Ischemic Cell Damage

1985 • 161 citations

Antisense oligonucleotide eliminates in vivo expression of c-fos in mammalian brain

1992 • 158 citations

Differential Expression of the Immediate Early Genes c-Fos, c-Jun, JunB, andNGFI-B in the Rat Brain following Transient Forebrain Ischemia

1994 • 128 citations

Visualization of DNA double strand breaks in the gerbil hippocampal CA1 following transient ischemia

1994 • 121 citations

p53 Expression in brain after middle cerebral artery occlusion in the rat

1992 • 120 citations

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation

1996 • 111 citations

Life and death by P53

1995 • 111 citations

c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways.

1996 • 101 citations

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

1990 • 94 citations

Internucleosomal DNA fragmentation in gerbil hippocampus following forebrain ischemia

1994 • 84 citations

Tumor Suppressor p53 Induction and DNA Damage in Hippocampal Granule Cells after Adrenalectomy

1994 • 62 citations

Inhibition of c‐Fos Protein Expression in Rat Spinal Cord by Antisense Oligodeoxynucleotide Superfusion

1994 • 56 citations

c-fos mediates antipsychotic-induced neurotensin gene expression in the rodent striatum

1995 • 51 citations

Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins

1994 • 37 citations

Up-regulation of c-myc gene expression following focal ischemia in the rat brain

1996 • 35 citations

Correlation of genetic and immunodetection of TP53 mutations in malignant and benign prostate tissues

1996 • 35 citations

Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia

1995 • 34 citations

Immunohistochemical detection of p53 protein in archival tissues from squamous cell carcinomas of the oral cavity using wet autoclave antigen retrieval

1995 • 32 citations

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation

1996 • 22 citations