Vascular targeting—a new approach to the therapy of solid tumors

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Cancer: Principles and Practice of Oncology.

1988 • 1,907 citations

Cancer: Principles and Practice of Oncology

1994 • 1,825 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

The Basic Science of Gene Therapy

1993 • 1,767 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

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1954 • 861 citations

Expression of the CD34 gene in vascular endothelial cells

1990 • 857 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms.

1992 • 824 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

1988 • 703 citations

An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

1989 • 659 citations

Site-Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall

1990 • 573 citations

Endothelial proliferation in tumours and normal tissues: Continuous labelling studies

1984 • 562 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels.

1991 • 495 citations

Vascular and interstitial barriers to delivery of therapeutic agents in tumors

1990 • 485 citations

Biologic Therapy of Cancer

1992 • 476 citations

Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.

1990 • 450 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Biology of Endothelial Cells

1984 • 426 citations

Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.

1987 • 418 citations

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.

1990 • 417 citations

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

1992 • 397 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Transport of fluid and macromolecules in tumors

1991 • 362 citations

Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface.

1992 • 341 citations

Phase I immunotoxin trial in patients with B-cell lymphoma.

1991 • 289 citations

Limitations of radiolabeled monoclonal antibodies for localization of human neoplasms.

1986 • 283 citations

Vascular attack as a therapeutic strategy for cancer

1990 • 267 citations

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors.

1989 • 257 citations

Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line.

1988 • 256 citations

Monoclonal antibody PAL-E specific for endothelium.

1985 • 251 citations

Endothelial-cell proliferation in experimental tumours

1982 • 236 citations

Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer.

1992 • 227 citations

Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment.

1984 • 217 citations

Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature.

1993 • 203 citations

Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.

1992 • 202 citations

Expression of organ-specific antigens on capillary endothelial cells

1985 • 200 citations

Structure of solid tumors and their vasculature: implications for therapy with monoclonal antibodies.

1991 • 200 citations

The Preparation and Cytotoxic Properties of Antibody‐Toxin Conjugates

1982 • 199 citations

Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice.

1990 • 199 citations

Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma.

1990 • 197 citations

A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues

1993 • 186 citations

Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts

1992 • 186 citations

A mouse lymphoid endothelial cell line immortalized by simian virus 40 binds lymphocytes and retains functional characteristics of normal endothelial cells.

1990 • 178 citations

Recombinant Interferon Enhances Monoclonal Antibody-Targeting of Carcinoma Lesions in Vivo

1987 • 178 citations

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor.

1991 • 178 citations

Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells.

1993 • 167 citations

A Novel Immediate-Early Response Gene of Endothelium Is Induced by Cytokines and Encodes a Secreted Protein

1990 • 159 citations

Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages.

1988 • 155 citations

Phase I trial of a mouse monoclonal antibody against GD3 ganglioside in patients with melanoma: induction of inflammatory responses at tumor sites.

1988 • 153 citations

Variable expression of Ia antigens on the vascular endothelium of mouse skin allografts

1983 • 143 citations

Angiogenic Activity as a Marker of Neoplastic and Preneoplastic Lesions of the Human Bladder

1980 • 142 citations

Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and IFN-gamma by human tumor-infiltrating lymphocytes after autologous tumor stimulation.

1991 • 138 citations

Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease

1991 • 133 citations

Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.

1992 • 129 citations

The significance of atypical vessels and neovascularization in cervical neoplasia

1981 • 123 citations

Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy.

1988 • 116 citations

Vasculature as a Target for Tumour Therapy

2015 • 109 citations

A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein.

1990 • 109 citations

Microvascular endothelial cell heterogeneity: Interactions with leukocytes and tumor cells

1990 • 104 citations

Immunolocalization of basic fibroblast growth factor to the micro vasculature of human brain tumors

1992 • 100 citations

Endoglin is expressed on a subpopulation of immature erythroid cells of normal human bone marrow.

1991 • 92 citations

Evaluation of ricin A chain-containing immunotoxins directed against the CD30 antigen as potential reagents for the treatment of Hodgkin's disease.

1990 • 89 citations

Radiation enhancement of radiolabelled antibody deposition in tumors

1987 • 86 citations

Cytokine Production (IL-1α, IL-1β, and TNFα) and Endothelial Cell Activation (ELAM-1 and HLA-DR) in Reactive Lymphadenitis, Hodgkin's Disease, and in Non-Hodgkin's Lymphomas: An Immunocytochemical Study

1990 • 85 citations

INFLAMMATION-INDUCED ENDOTHELIAL CELL ADHESION TO LYMPHOCYTES, NEUTROPHILS, AND MONOCYTES

1989 • 84 citations

Angiogenesis and its inhibitors.

1985 • 83 citations

Influence of tumor-derived interleukin 1 on melanoma-endothelial cell interactions in vitro.

1991 • 81 citations

Studies on B lymphoid tumors treated with monoclonal anti-idiotype antibodies: correlation with clinical responses

1987 • 79 citations

Therapeutic strategies with monoclonal antibodies and immunoconjugates.

1988 • 76 citations

Antitumor effects of ricin A chain immunotoxins prepared from intact antibodies and Fab' fragments on solid human Hodgkin's disease tumors in mice.

1990 • 76 citations

The identification and localization of fibronectin in cultured corneal endothelial cells: Cell surface polarity and physiological implications

1979 • 73 citations

Endoglin: a 180-kD endothelial cell and macrophage restricted differentiation molecule

1992 • 71 citations

Guinea pig line 10 hepatocarcinoma model: characterization of monoclonal antibody and in vivo effect of unconjugated antibody and antibody conjugated to diphtheria toxin A chain.

1983 • 71 citations

Evaluation of four CD22 antibodies as ricin a chain‐containing immunotoxins for the in vivo therapy of human B‐cell leukemias and lymphomas

1988 • 71 citations

Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in vivo: kinetics and implications for diagnosis and therapy.

1987 • 70 citations

A monoclonal antibody reacting with endothelial cells of budding vessels in tumors and inflammatory tissues, and non‐reactive with normal adult tissues

1986 • 68 citations

Antibody Toxin Conjugates: A Perspective

2015 • 66 citations

Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding.

1990 • 66 citations

Modulation of vascular cell behavior by transforming growth factors β

1992 • 61 citations

Differential effects of recombinant human leukocyte interferons on cell surface antigen expression.

1986 • 61 citations

A New 180-kDa Dermal Endothelial Cell Activation Antigen: In Vitro and In Situ Characteristics

1993 • 60 citations

Microdistribution of specific rat monoclonal antibodies to mouse tissues and human tumor xenografts.

1991 • 57 citations

Penetration of Tumor Tissue by Antibodies and Other Immunoproteins

1991 • 54 citations

A murine model for antibody-directed targeting of vascular endothelial cells in solid tumors.

1992 • 54 citations

Use of vasoactive agents to increase tumor perfusion and the antitumor efficacy of drug-monoclonal antibody conjugates.

1987 • 48 citations

Local distribution and concentration of intravenously injected 131I-9.2.27 monoclonal antibody in human malignant melanoma.

1989 • 40 citations

In situ distribution of the beta-subunit of platelet-derived growth factor receptor in nonneoplastic tissue and in soft tissue tumors.

1990 • 39 citations

The spatial distribution of immunotoxins in solid tumors: assessment by quantitative autoradiography.

1993 • 37 citations

Modulation of tumor associated antigen expression and shedding by recombinant human leukocyte and fibroblast interferons

1985 • 34 citations

Characterization of tumors produced by signal peptide‐basic fibroblast growth factor‐transformed cells

1989 • 30 citations

Innovative and future approaches to small cell lung cancer treatment.

1988 • 29 citations

Effects of target antigen competition on distribution of monoclonal antibody to solid tumors.

1992 • 27 citations

Potent cytotoxic action of the immunotoxin SWA11-ricin A chain against human small cell lung cancer cell lines

1992 • 24 citations

Highly efficient action of autocrine mouse interferon‐γ expressed via a retroviral vector

1988 • 23 citations

Biotechnology Update: Overview of Monoclonal Antibodies in the Diagnosis and Therapy of Cancer

1991 • 23 citations

Resistance of myeloid leukaemia cell lines to ricin a-chain immunotoxins

1991 • 22 citations

Uptake and distribution of specific and control monoclonal antibodies in subcutaneous xenografts following intratumor injection.

1991 • 22 citations

Targeting the vasculature of solid tumours

1997 • 21 citations

Monoclonal Antibody Therapy of Solid Tumors

1985 • 20 citations

Antibody targeted therapy in cancer: comparison of murine and clinical studies

1990 • 20 citations

In vivo fluorescence of endothelial cell nuclei stained with the dye Bis-benzamide H 33342.

1983 • 19 citations

Intratumoral and whole-body distributions of C110 anti-carcinoembryonic antigen radioimmunotoxin after intraperitoneal and intravenous injection: a quantitative autoradiographic study.

1992 • 19 citations

Monoclonal Antibody Therapy of Human Cancer

1985 • 19 citations

Innovative and future approaches to small cell lung cancer treatment

1989 • 12 citations

Human tumor-associated antigens defined by monoclonal antibodies.

1984 • 11 citations

Localization of biotinylated monoclonal antibody in nude mice bearing subcutaneous and intraperitoneal human tumour xenografts

1988 • 11 citations

Survey of human cancer patient sera for adenovirus “T” antibody by immunofluorescence

1968 • 11 citations

Effects of an anti HLA-DR immunotoxin on leukaemia cells and hematopoietic progenitors

1989 • 8 citations

Targeting the vasculature of solid tumors

1994 • 4 citations