The Preparation and Cytotoxic Properties of Antibody‐Toxin Conjugates

Determination of free amino groups in proteins by trinitrobenzenesulfonic acid

1966 • 2,029 citations

SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

1965 • 1,851 citations

Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent

1978 • 1,226 citations

Diphtheria Toxin

1977 • 780 citations

One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

1978 • 744 citations

Proteinases in mammalian cells and tissues

1978 • 701 citations

The kinetics of antibody binding to membrane antigens in solution and at the cell surface

1980 • 568 citations

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

1980 • 484 citations

Structural determinants of Ricinus communis agglutinin and toxin specificity for oligosaccharides.

1979 • 482 citations

Bacterial toxins and cell membranes

1978 • 471 citations

Diphtheria toxin entry into cells is facilitated by low pH.

1980 • 467 citations

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement.

1980 • 372 citations

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

1978 • 372 citations

Lysosomes: A laboratory handbook

1978 • 367 citations

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

1978 • 358 citations

Isolation and Comparison of Galactose-binding Lectins from Abrus precatorius and Ricinus communis

1974 • 341 citations

Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A.

1980 • 321 citations

Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells

1980 • 305 citations

Diphtheria Toxin and Related Proteins

1973 • 285 citations

Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells.

1980 • 270 citations

Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells

1981 • 253 citations

Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells.

1976 • 238 citations

Coated pits act as molecular filters.

1980 • 208 citations

PHARMACOLOGY OF BACTERIAL TOXINS.

1964 • 192 citations

Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin.

1980 • 190 citations

Monoclonal Antibodies in Clinical Medicine

1983 • 181 citations

Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin.

1980 • 168 citations

Immunochemotherapy of Cancer with Chlorambucil-carrying Antibody

1972 • 164 citations

Selective Destruction of Target Cells by Diphtheria Toxin Conjugated to Antibody Directed against Antigens on the Cells

1970 • 162 citations

Epidermal growth factor-toxin A chain conjugates: EGF-Ricin A is a potent toxin while EGF-diphtheria fragment A is nontoxic

1980 • 144 citations

Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin.

1976 • 124 citations

An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver. II. Intracellular fates of the 125I-ligands.

1979 • 123 citations

Cytotoxicity Acquired by Conjugation of an Anti‐Thy_1.1 Monoclonal Antibody and the Ribosome‐Inactivating Protein, Gelonin

1981 • 122 citations

Effect of temperature on the uptake, excretion and degradation of abrin and ricin by HeLa cells

1979 • 120 citations

Isolation and characterization of carcinoembryonic antigen (CEA) extracted from normal human colon mucosa

1977 • 98 citations

In Vitro Inhibition of Diphtheria Toxin Action by Ammonium Salts and Amines

1965 • 89 citations

Studies on the galactose-binding site of ricin and the hybrid toxin man6P-ricin

1981 • 88 citations

Artificial hybrid protein containing a toxic protein fragment and a cell membrane receptor-binding moiety in a disulfide conjugate. II. Biochemical and biologic properties of diphtheria toxin fragment A-S-S-human placental lactogen.

1977 • 86 citations

Toxicity of diphtheria toxin for lymphoblastoid cells is increased by conjugation to antilymphocytic globulin

1978 • 84 citations

Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with fragment A from diphtheria toxin

1978 • 81 citations

Ultrastructural analysis of toxin binding and entry into mammalian cells

1974 • 77 citations

Ricin linked to monophosphopentamannose binds to fibroblast lysosomal hydrolase receptors, resulting in a cell-type-specific toxin.

1979 • 71 citations

A hybrid protein containing the toxic subunit of ricin and the cell-specific subunit of human chorionic gonadotropin. II. Biologic properties.

1979 • 69 citations

Specific cytotoxicity of a human immunoglobulin-directed Fab'-ricin A chain conjugate.

1980 • 65 citations

High specific cytotoxicity of antibody-toxin hybrid molecules (immunotoxins) for target cells

1980 • 60 citations

Synthesis of a cytotoxic insulin cross-linked to diphtheria toxin fragment a capable of recognizing insulin receptors

1979 • 59 citations

Preparation of a hybrid of fragment Fab' of antibody and fragment a of diphtheria toxin and its cytotoxicity

1979 • 55 citations

Reconstitution of hybrid toxin from Fragment A of diphtheria toxin and a subunit of Wistaria floribunda lectin.

1978 • 55 citations

Seed extracts inhibiting protein synthesis in vitro

1980 • 55 citations

Antitumor Effects of Antibody-Diphtheria Toxin Coniugates. II. Immunotherapy With Coniugates Directed Against Tumor Antigens Induced by Simian Virus 40<xref ref-type="fn" rid="fn2">2</xref>

1975 • 50 citations

Antitumor Effects of Antibody-Diphtheria Toxin Conjugates: Use of Hapten-Coated Tumor Cells as an Antigenic Target<xref ref-type="fn" rid="FN2">2</xref>

1972 • 47 citations

Asialoglycoprotein receptor mediates the toxic effects of an asialofetuin-diphtheria toxin fragment A conjugate on cultured rat hepatocytes.

1981 • 47 citations

A method for the preparation of protein-protein conjugates of predetermined composition

1978 • 46 citations

Antitumor Effects of Antibody—Diphtheria Toxin Conjugates. III. Cyclophosphamide-Induced Immune Unresponsiveness to Conjugates2

1975 • 46 citations

Increased Toxicity of Diphtheria Toxin for Human Lymphoblastoid Cells following Covalent Linkage to Anti-(human lymphocyte) Globulin or Its F(ab')2 Fragment

1980 • 45 citations

Hybrid toxin of the A chain of ricin toxin and a subunit of Wistaria floribunda lectin. Possible importance of the hydrophobic region for entry of toxin into the cell.

1980 • 43 citations

Primary structure of Ile chain of ricin D.

1978 • 43 citations

Monoclonal Antibodies That Define T-Lymphocyte Subsets in the Rat

1980 • 38 citations

Preparation of Concanavalin A-Ricin A-Chain Conjugate and Its Biologic Activity Against Various Cultured Cells<xref ref-type="fn" rid="FN2">2</xref>

1979 • 37 citations

Abrogation of the non-specific toxicity of abrin conjugated to anti-lymphocyte globulin.

1981 • 31 citations

ANTIBODIES AS CARRIERS OF ANTICANCER AGENTS

1974 • 27 citations

Target-cell cytotoxicity of a hybrid of Fab' on immunoglobulin and A-chain of ricin.

1980 • 26 citations

The amino acid sequence of fragment A, an enzymically active fragment of diphtheria toxin. III. The chymotryptic peptides, the peptides derived by cleavage at tryptophan residues, and the complete sequence of the protein.

1979 • 23 citations

Chemical Modifications of the Toxic Lectins Abrin and Ricin

1978 • 22 citations

A model system involving anti-concanavalin A for antibody targeting of diphtheria toxin fragment A1.

1980 • 18 citations

The interaction of chlorambucil with human γ-globulin

1974 • 18 citations

The effect of abrin, anti-lymphocyte globulin and their conjugates on the immune response of mice to sheep red blood cells

1981 • 13 citations

Preparation of antibody (IgG)-ricin A-chain conjugate and its biologic activity.

1980 • 13 citations

The conjugation of chlorambucil with human γ-globulin

1975 • 13 citations

547. Aryl-2-halogenoalkylamines. Part III. The reactions of NN-di-2-chloroethyl-p-anisidine and β-naphthyldi-2-chloroethylamine in aqueous-acetone salt solutions

1949 • 9 citations

Dynamic Changes on the Surfaces of Normal and Transformed Cells and Their Relationship to the Entry of Pharmacologically Active Proteins

1975 • 6 citations

594. Aryl-2-halogenoalkylamines. Part IV. The reactions of NN-di-2-chloroethyl-p-anisidine and β-naphthyldi-2-chloroethylamine in aqueous acetone solutions of amines

1949 • 4 citations