β2-Chimaerin is a novel target for diacylglycerol: Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Automated docking of flexible ligands: Applications of autodock

1996 • 1,500 citations

Evaluation of comparative protein modeling by M<scp>ODELLER</scp>

1995 • 1,066 citations

Regulation of protein kinase C

1997 • 919 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Taxonomy and function of C1 protein kinase C homology domains

1997 • 350 citations

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

1991 • 316 citations

Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes.

1993 • 275 citations

The Coatomer Protein β′-COP, a Selective Binding Protein (RACK) for Protein Kinase Cε

1997 • 251 citations

Arachidonic Acid in Platelet Microparticles Up-regulates Cyclooxygenase-2-dependent Prostaglandin Formation via a Protein Kinase C/Mitogen-activated Protein Kinase-dependent Pathway

1999 • 240 citations

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.

1994 • 237 citations

Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed Mutagenesis

1995 • 149 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

Three Distinct Mechanisms for Translocation and Activation of the δ Subspecies of Protein Kinase C

1998 • 135 citations

Non-equivalent Roles for the First and Second Zinc Fingers of Protein Kinase Cδ

1996 • 133 citations

Solution structure of a cysteine rich domain of rat protein kinase C

1994 • 131 citations

Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products

1994 • 120 citations

Protein Kinase Cα Contains Two Activator Binding Sites That Bind Phorbol Esters and Diacylglycerols with Opposite Affinities

1996 • 114 citations

Highly lipophilic phorbol esters as inhibitors of specific [3H]phorbol 12,13-dibutyrate binding.

1985 • 110 citations

Visualization of Dynamic Trafficking of a Protein Kinase C βII/Green Fluorescent Protein Conjugate Reveals Differences in G Protein-coupled Receptor Activation and Desensitization

1998 • 105 citations

A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide.

1994 • 105 citations

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis.

1993 • 104 citations

Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.

1993 • 95 citations

β2-Chimaerin Is a High Affinity Receptor for the Phorbol Ester Tumor Promoters

1997 • 95 citations

Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors.

1994 • 81 citations

Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain.

1994 • 75 citations

Low Affinity Binding of Phorbol Esters to Protein Kinase C and Its Recombinant Cysteine-rich Region in the Absence of Phospholipids

1995 • 65 citations

Solution Structure of Cysteine-Rich Domain of Protein Kinase Cα1

1995 • 56 citations

Presence of a beta II protein kinase C-selective nuclear membrane activation factor in human leukemia cells.

1994 • 51 citations

Conformationally constrained analogs of diacylglycerol. Interaction of .gamma.-lactones with the phorbol ester receptor of protein kinase C

1992 • 35 citations

Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes.

1995 • 27 citations

Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ

1997 • 24 citations

Conformationally constrained analogues of diacylglycerol (DAG). 15.1 The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C)

1998 • 18 citations

α2-Chimerin, an SH2-Containing GTPase-Activating Protein for the ras-Related Protein p21^rac Derived by Alternate Splicing of the Human n-Chimerin Gene, Is Selectively Expressed in Brain Regions and Testes

1993 • 17 citations

Conformationally constrained analogues of diacylglycerol. 6. Changes in PK-C binding affinity for 3-O-acyl-2-deoxy-L-ribonolactones bearing different acyl chains.

1994 • 13 citations

Conformationally constrained analogues of diacylglycerol (DAG). 3. Interaction of α-alkyl-γ-lactones with protein kinase C (PK-C)

1993 • 10 citations

Conformationally constrained analogues of diacylglycerol (DAG)-II. Differential interaction of δ-lactones and γ-lactones with protein kinase C (PK-C)

1993 • 8 citations

Conformationally constrained analogues of diacylglycerol (DAG). 4. Interaction of α-alkylidene-γ-lactones with protein kinase C (PK-C)

1993 • 5 citations