The N-terminal Domain of 5-Lipoxygenase Binds Calcium and Mediates Calcium Stimulation of Enzyme Activity

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Twilight zone of protein sequence alignments

1999 • 1,691 citations

C2-domains, Structure and Function of a Universal Ca2+-binding Domain

1998 • 835 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

New insights into the regulation of protein kinase C and novel phorbol ester receptors

1999 • 600 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

The Three-Dimensional Structure of an Arachidonic Acid 15-Lipoxygenase

1993 • 460 citations

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

1997 • 436 citations

Crystal Structure of Soybean Lipoxygenase L-1 at 1.4 Å Resolution^,

1996 • 395 citations

Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

1998 • 268 citations

Steric analysis of hydroperoxides formed by lipoxygenase oxygenation of linoleic acid

1971 • 238 citations

5-Lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

2000 • 216 citations

Role of Phosphorylation Sites and the C2 Domain in Regulation of Cytosolic Phospholipase A2

1999 • 207 citations

Mechanism of Phospholipid Binding by the C₂A-Domain of Synaptotagmin I

1998 • 191 citations

Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme

1997 • 159 citations

Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C

1997 • 151 citations

A Structure-Function Study of the C2 Domain of Cytosolic Phospholipase A2

1999 • 137 citations

Membrane Translocation of 15-Lipoxygenase in Hematopoietic Cells Is Calcium-Dependent and Activates the Oxygenase Activity of the Enzyme

1998 • 132 citations

Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically

1998 • 128 citations

Independent Folding and Ligand Specificity of the C2 Calciumdependent Lipid Binding Domain of Cytosolic Phospholipase A2

1998 • 127 citations

Mapping the Phospholipid-binding Surface and Translocation Determinants of the C2 Domain from Cytosolic Phospholipase A2

1999 • 125 citations

Interaction of 5-lipoxygenase with cellular proteins

1999 • 120 citations

Cloning of the cDNA for human 12-lipoxygenase.

1990 • 117 citations

Molecular cloning of a 12‐lipoxygenase cDNA from rat brain

1993 • 115 citations

Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A 2 1 1Edited by J. Karn

1998 • 106 citations

Two immunologically and catalytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes

1988 • 105 citations

Mutagenesis of some conserved residues in human 5-lipoxygenase: effects on enzyme activity.

1992 • 86 citations

Interfacial membrane docking of cytosolic phospholipase A ₂ C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance

1999 • 80 citations

Location of the Membrane-Docking Face on the Ca²⁺-Activated C2 Domain of Cytosolic Phospholipase A₂

1998 • 79 citations

Homology modeling with internal coordinate mechanics: Deformation zone mapping and improvements of models via conformational search

1997 • 73 citations

5-Lipoxygenase Binds Calcium

1999 • 73 citations

Assessment of comparative modeling in CASP2

1997 • 73 citations

Purification and characterization of recombinant histidine‐tagged human platelet 12‐lipoxygenase expressed in a baculovirus/insect cell system

1993 • 67 citations

Mutations at the C-Terminal Isoleucine and Other Potential Iron Ligands of 5-Lipoxygenase

1995 • 63 citations

Lipoxygenases and their Products

1991 • 63 citations

Calcium Induces Membrane Translocation of 12-Lipoxygenase in Rat Platelets

1989 • 60 citations

Subcellular localization and some properties of lipoxygenase activity in human blood platelets

1984 • 59 citations

Activity and protein distribution of 12-lipoxygenase in HEL cells: Induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca2+-dependent translocation to membranes

1993 • 55 citations

Regulation of the human leukocyte 5-lipoxygenase: stimulation by micromolar Ca2+ levels and phosphatidylcholine vesicles

1988 • 54 citations

Uncovering a Calcium-Regulated Membrane-Binding Mechanism for Soybean Lipoxygenase-1

1998 • 52 citations

Homology modeling with internal coordinate mechanics: Deformation zone mapping and improvements of models via conformational search

1997 • 52 citations

Human 5-lipoxygenase associates with phosphatidylcholine liposomes and modulates LTA4 synthetase activity

1994 • 41 citations

Calcium ion activation of lipoxidase

1968 • 41 citations

The N‐terminal β‐barrel structure of lipid body lipoxygenase mediates its binding to liposomes and lipid bodies

2000 • 40 citations

Calcium promotes membrane association of reticulocyte 15-lipoxygenase

1994 • 39 citations

Mg²⁺ Activates 5-Lipoxygenase in Vitro: Dependency on Concentrations of Phosphatidylcholine and Arachidonic Acid

2000 • 38 citations

Lipoxin and Aspirin-Triggered 15-epi-Lipoxin Cellular Interactions Anti-Inflammatory Lipid Mediators

1999 • 35 citations

Calcium stimulation of a novel 12-lipoxygenase from rat basophilic leukemia (rbl-1) cells

1984 • 33 citations

Calcium Is Not Required for 5-Lipoxygenase Activity at High Phosphatidyl Choline Vesicle Concentrations

1998 • 27 citations

Purification of two forms of arachidonate 15‐lipoxygenase from human leukocytes

1991 • 20 citations

Novel Inhibitors of Leukotrienes

1999 • 15 citations

Effect of Calcium on the Oxidation of Linoleic Acid by Potato (Solanum tuberosum Var. Desiree) Tuber 5-Lipoxygenase

2000 • 3 citations