Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots

1970 • 3,260 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Small-volume extrusion apparatus for preparation of large, unilamellar vesicles

1991 • 1,461 citations

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

1992 • 968 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

1997 • 788 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

Calcium dependence of the rate of exocytosis in a synaptic terminal

1994 • 746 citations

Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse

1981 • 704 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

1995 • 597 citations

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue.

1981 • 560 citations

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1993 • 551 citations

Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.

1993 • 540 citations

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

1996 • 526 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Synaptotagmins: C2-Domain Proteins That Regulate Membrane Traffic

1996 • 439 citations

Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1

1995 • 372 citations

Structural Changes Are Associated with Soluble N-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation

1997 • 369 citations

Genetic and electrophysiological studies of drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission

1995 • 321 citations

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1997 • 309 citations

Bipartite Ca ²⁺ -Binding Motif in C ₂ Domains of Synaptotagmin and Protein Kinase C

1996 • 307 citations

SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.

1994 • 288 citations

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.

1994 • 286 citations

Ultrafast Exocytosis Elicited by Calcium Current in Synaptic Terminals of Retinal Bipolar Neurons

1996 • 259 citations

The effect on synaptic physiology of synaptotagmin mutations in drosophila

1994 • 253 citations

Synaptotagmin–Syntaxin Interaction: The C2 Domain as a Ca2+-Dependent Electrostatic Switch

1997 • 244 citations

Mechanism of Interaction of Protein Kinase C with Phorbol Esters

1995 • 243 citations

Membrane trafficking in the presynaptic nerve terminal

1995 • 217 citations

Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.

1994 • 209 citations

A Novel Function for the Second C2 Domain of Synaptotagmin

1996 • 197 citations

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain

1997 • 195 citations

Interaction of Proteins With Lipid Headgroups: Lessons from Protein Kinase C

1993 • 184 citations

The Evolutionary Pressure to Inactivate

1997 • 166 citations

Localization of synaptotagmin-binding domains on syntaxin

1996 • 158 citations

A Ternary Metal Binding Site in the C2 Domain of Phosphoinositide-Specific Phospholipase C-δ1^,

1997 • 146 citations

Role of calcium in the adhesion and fusion of bilayers

1993 • 144 citations

Distinct Ca2+-dependent Properties of the First and Second C2-domains of Synaptotagmin I

1996 • 137 citations

Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains.

1993 • 132 citations

Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles

1992 • 125 citations

Ca²⁺-Signaling Cycle of a Membrane-Docking C2 Domain

1997 • 117 citations

Protein kinase C interaction with calcium: a phospholipid-dependent process

1990 • 116 citations

C2 domain conformational changes in phospholipase C-δ1

1996 • 104 citations

A novel seizure-induced synaptotagmin gene identified by differential display

1997 • 76 citations

Calcium‐Dependent Self‐Association of Synaptotagmin I

1996 • 55 citations