DNA methylation and chromosome instability in breast cancer cell lines

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification.

1998 • 973 citations

DNA hypomethylation leads to elevated mutation rates

1998 • 935 citations

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

1999 • 830 citations

A mammalian protein with specific demethylase activity for mCpG DNA

1999 • 624 citations

DNA methylation and genetic instability in colorectal cancer cells

1997 • 400 citations

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.

1999 • 392 citations

Sex-specific exons control DNA methyltransferase in mammalian germ cells

1998 • 332 citations

A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast

1998 • 274 citations

Hypomethylation of pericentromeric DNA in breast adenocarcinomas

1998 • 263 citations

Jumping Translocations of Chromosome 1q in Multiple Myeloma: Evidence for a Mechanism Involving Decondensation of Pericentromeric Heterochromatin

1998 • 222 citations

Breast cancer genetic evolution: I. Data from cytogenetics and DNA content

1991 • 142 citations

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1996 • 138 citations

New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase

1996 • 96 citations

Specific induction of uncoiling and recombination by azacytidine in classical satellite-containing constitutive heterochromatin

1993 • 86 citations

Hypomethylation of classical satellite DNA and chromosome instability in lymphoblastoid cell lines

1993 • 85 citations

DNA hypomethylation in breast cancer: An independent parameter of tumor progression?

1997 • 79 citations

α-Satellite DNA methylation in normal individuals and in ICF patients: heterogeneous methylation of constitutive heterochromatin in adult and fetal tissues

1997 • 77 citations

Multiple Isoforms of DNA Methyltransferase Are Encoded by the Vertebrate Cytosine DNA Methyltransferase Gene

1998 • 30 citations

Two adjacent mutations at position 12 activate the K-ras2 oncogene of a human mammary tumor cell line.

1987 • 14 citations