Clonal Heterogeneity in Human Esophageal Squamous Cell Carcinomas on DNA Analysis

Molecular cloning: A laboratory manual

1990 • 85,659 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

A second-generation linkage map of the human genome

1992 • 1,721 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

Cancer statistics, 1991

1991 • 625 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products

1991 • 556 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Prognostic significance of p53 mutations and 3p deletions in primary, resected non-small cell lung cancer

1995 • 333 citations

Molecular Analysis of the Short Arm of Chromosome 3 in Small-Cell and Non-Small-Cell Carcinoma of the Lung

1987 • 331 citations

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

1994 • 329 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers.

1992 • 215 citations

Microsatellite instability occurs frequently in human gastric carcinoma.

1994 • 203 citations

Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix.

1989 • 192 citations

Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer.

1994 • 187 citations

p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail.

1994 • 183 citations

Allelic loss in locally metastatic, multisampled prostate cancer.

1994 • 170 citations

Three discrete regions of deletion at 3p in head and neck cancers.

1993 • 166 citations

Microsatellite instability occurs frequently and in both diploid and aneuploid cell populations of Barrett's-associated esophageal adenocarcinomas.

1994 • 138 citations

Assessment of clonality in human tumors: a review.

1990 • 135 citations

p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment.

1996 • 130 citations

Optimization of Nonradioisotopic Single Strand Conformation Polymorphism Analysis with a Conventional Minislab Gel Electrophoresis Apparatus

1993 • 123 citations

Mutations of the Transforming Growth Factor-β Type II Receptor Gene and Genomic Instability in Hereditary Nonpolyposis Colorectal Cancer

1995 • 103 citations

Cancer statistics, 1991.

1991 • 96 citations

Deletion mapping of chromosome 3p in female genital tract malignancies using microsatellite polymorphisms.

1992 • 96 citations

Chromosome 3p deletions in head and neck carcinomas: Statistical ascertainment of allelic loss

1992 • 74 citations

Frequent microsatellite alterations on chromosome 3p in esophageal squamous cell carcinoma.

1995 • 69 citations

Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers.

1995 • 51 citations

Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as a evidence for multistage progression

1994 • 47 citations

DNA alterations in cells from hereditary non-polyposis colorectal cancer patients.

1994 • 35 citations

Infrequent Replication Errors at Microsatellite Loci in Tumors of Patients with Multiple Primary Cancers of the Esophagus and Various Other Tissues

1995 • 21 citations