Current status of adjuvant chemotherapy for colorectal cancer: Can molecular markers play a role in predicting prognosis?

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

ras GENES

1987 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Levamisole and Fluorouracil for Adjuvant Therapy of Resected Colon Carcinoma

1990 • 2,226 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Effective Surgical Adjuvant Therapy for High-Risk Rectal Carcinoma

1991 • 1,888 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Prolongation of the Disease-Free Interval in Surgically Treated Rectal Carcinoma

1985 • 1,097 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Adjuvant Therapy for Patients With Colon and Rectal Cancer

1990 • 1,047 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Tumor suppressor genes

1991 • 775 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic.

1989 • 694 citations

The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5

1987 • 683 citations

Clonal Analysis of Human Colorectal Tumors

1987 • 638 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Chromosome 5 allele loss in human colorectal carcinomas

1987 • 566 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

1984 • 524 citations

Tumor Suppressor Genes: The Puzzle and the Promise

1989 • 488 citations

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.

1990 • 407 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

Allelic Loss in Colorectal Carcinoma

1989 • 338 citations

Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.

1986 • 335 citations

MULTIPLE GENETIC ALTERATIONS IN DISTAL AND PROXIMAL COLORECTAL CANCER

1989 • 306 citations

Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells.

1982 • 279 citations

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]

1989 • 273 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

p53 transformation-related protein: Detection by monoclonal antibody in mouse and human cells

1981 • 222 citations

Oncogenes and Tumor-Suppressing Genes

1988 • 222 citations

Randomised Comparison of Cisplatin with Cyclophosphamide/Cisplatin and with Cyclophosphamide/Doxorubicin/Cisplatin in Advanced Ovarian Cancer

1988 • 218 citations

When the products of oncogenes and anti-oncogenes meet

1989 • 213 citations

c-myc oncogene expression in colorectal cancer

1987 • 185 citations

Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli

1988 • 157 citations

Concerted Nonsyntenic Allelic Loss in Human Colorectal Carcinoma

1988 • 147 citations

Human colorectal cancer: high frequency of deletions at chromosome 1p35.

1990 • 140 citations

Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus.

1988 • 131 citations

Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.

1990 • 127 citations

p53 Cellular Tumor Antigen: Analysis of mRNA Levels in Normal Adult Tissues, Embryos, and Tumors

1985 • 117 citations

Inhibition of cell growth mediated by plasmids encoding p53 anti-sense.

1987 • 99 citations

Loss of alleles on chromosome 18 and on the short arm of chromosome 17 in polyploid colorectal carcinomas

1988 • 97 citations

Loss of constitutional heterozygosity in colorectal tumors from patients with familial polyposis coli and those with nonpolyposis colorectal carcinoma.

1989 • 81 citations

Retinoblastoma and the progression of tumor genetics

1988 • 80 citations

Evidence that c-myc expression defines two genetically distinct forms of colorectal adenocarcinoma

1985 • 76 citations

Loss of a highly conserved domain on p53 as a result of gene deletion during Friend virus-induced erythroleukemia.

1988 • 75 citations

The c-myc protein is constitutively expressed at elevated levels in colorectal carcinoma cell lines.

1988 • 54 citations

Origins of human cancer revisited

1990 • 53 citations

Chromosome 5 allele loss in familial and sporadic colorectal adenomas

1989 • 43 citations

Chromosome 5 allele loss at the glucocorticoid receptor locus in human colorectal carcinomas

1988 • 42 citations

Tumor suppressor genes and inherited predisposition to malignancy.

1989 • 20 citations

Chromosome 18 allele loss at the D18S6 locus in human colorectal carcinomas

1988 • 20 citations

Tumour suppressor genes: Oncogenesis update

1989 • 8 citations

Oncogenes and their involvement in chronic myelogenous leukemia

1987 • 4 citations