Prolactin-Regulated Apoptosis of Nb2 Lymphoma Cells: pim-1 , bcl-2 , and bax Expression

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Genomic sequencing.

1984 • 8,343 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Prolactin-stimulated growth of cell cultures established from malignant Nb rat lymphomas.

1980 • 279 citations

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.

1989 • 234 citations

Prolactin-induced proliferation of Nb2 cells involves tyrosine phosphorylation of the prolactin receptor and its associated tyrosine kinase JAK2.

1994 • 226 citations

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.

1990 • 223 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes.

1994 • 158 citations

Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines.

1988 • 141 citations

The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent

1996 • 137 citations

DNA fragmentation during apoptosis is caused by frequent single-strand cuts

1993 • 129 citations

Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice.

1993 • 121 citations

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.

1995 • 105 citations

Rapid modulation of the apoptosis regulatory genes, bcl-2 and bax by prolactin in rat Nb2 lymphoma cells.

1996 • 97 citations

Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues

1995 • 94 citations

Investigation of Intracellular Signals Mediating the Anti-Apoptotic Action of Prolactin in Nb2 Lymphoma Cells

1995 • 72 citations

Rapid induction of pim-1 expression by prolactin and interleukin-2 in rat Nb2 lymphoma cells.

1995 • 67 citations

Glucocorticoid-Prolactin Interactions in Nb2 Lymphoma Cells: Antiproliferative versus Anticytolytic Effects

1993 • 56 citations

Deregulated Bcl-2-Immunoglobulin Transgene Expands a Resting but Responsive Immunoglobulin M and D-Expressing B-Cell Population

1990 • 54 citations

Biphasic transcriptional regulation of the interferon regulatory factor-1 gene by prolactin: involvement of gamma-interferon-activated sequence and Stat-related proteins.

1995 • 52 citations

Biochemical response of lymphoma cells to mitogenic stimulation by prolactin

1982 • 47 citations

Ubiquitous Expression and Cell Cycle Regulation of the Protein Kinase PIM-1

1996 • 46 citations

Comparison of Glucocorticoid-Induced Effects in Prolactin-Dependent and Autonomous Rat Nb2 Lymphoma Cells

1993 • 45 citations

Inhibition by genistein of prolactin-induced Nb2 lymphoma cell mitogenesis

1993 • 41 citations

Rapid activation of mitogen-activated protein kinase and p21ras by prolactin and interleukin 2 in rat Nb2 node lymphoma cells.

1995 • 40 citations

Thymic origin of the prolactin-dependent Nb2 lymphoma cell line.

1982 • 34 citations

Cloning and characterization of the human PIM‐1 gene: A putative oncogene related to the protein kinases

1987 • 30 citations

The rat Nb2 lymphoma: a novel model for tumor progression.

1994 • 19 citations

Involvement of Pim-1 in DNA Fragmentation in Mouse NS-1-Derived Cells

1995 • 14 citations