Perturbation of EGF-activated MEK1 and PKB signal pathways by TGF-?1 correlates with perturbation of EGF-induced cyclin D1 and DNA synthesis by TGF-?1 in C3H 10T1/2 cells

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

The modular phosphorylation and activation of p70^s6k

1997 • 539 citations

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1998 • 510 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and -2 Are Induced by the p42/p44MAPK Cascade

1997 • 358 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Induction of cyclin D1 by simian virus 40 small tumor antigen

1996 • 209 citations

Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation

1999 • 175 citations

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.

1996 • 168 citations

FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.

1994 • 167 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Phosphorylation Sites in the Autoinhibitory Domain Participate in p70s6k Activation Loop Phosphorylation

1998 • 135 citations

Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells

1997 • 121 citations

Epidermal Growth Factor and c-Jun Act via a Common DNA Regulatory Element to Stimulate Transcription of the Ovine P-450 Cholesterol Side Chain Cleavage (CYP11A1) Promoter

1995 • 107 citations

Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-Jun N-terminal kinase.

1996 • 83 citations

Regulation of the MAP kinase cascade in PC12 cells: B‐Raf activates MEK‐1 (MAP kinase or ERK kinase) and is inhibited by cAMP

1995 • 82 citations

A target for phosphoinositide 3-kinase: Akt/PKB

1995 • 80 citations

Transforming Growth Factor-β1 Stimulates Protein Kinase A in Mesangial Cells

1998 • 77 citations

Catalytic Activation of Extracellular Signal-regulated Kinases Induces Cyclin D₁ Expression in Primary Tracheal Myocytes

1998 • 76 citations

Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells

1998 • 66 citations

Inhibition of the Raf-1 Kinase by Cyclic AMP Agonists Causes Apoptosis of v-abl-Transformed Cells

1997 • 65 citations

Thyrotropin-Induced Mitogenesis Is Ras Dependent but Appears To Bypass the Raf-Dependent Cytoplasmic Kinase Cascade

1995 • 60 citations

Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture

1999 • 47 citations

Differential regulation of p27 and cyclin D1 by TGF-β and EGF in C3H 10T1/2 mouse fibroblasts

1996 • 42 citations

Transforming growth factor alpha (TGFα) induction of c-fos and c-myc expression in C3H 10Tl/2 cells

1988 • 25 citations

Transforming growth factor‐β regulation of retinoblastoma gene product and E2F transcription factor during cell cycle progression in mouse fibroblasts

1994 • 21 citations

Transforming growth factor β1-induced delay of cell cycle progression and its association with growth-related gene expression in mouse fibroblasts

1993 • 17 citations