Conferring specificity on the ubiquitous Raf/MEK signalling pathway

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

22q11.21 Deletion Syndromes: A Review of Proximal, Central, and Distal Deletions and Their Associated Features

2015 • 1,875 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

Molecular interpretation of ERK signal duration by immediate early gene products

2002 • 914 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Ras signalling on the endoplasmic reticulum and the Golgi

2002 • 612 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1999 • 456 citations

Raf proteins and cancer: B-Raf is identified as a mutational target

2003 • 454 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

Ras Activation of the Raf Kinase: Tyrosine Kinase Recruitment of the MAP Kinase Cascade

2001 • 384 citations

Localization of the MP1-MAPK Scaffold Complex to Endosomes Is Mediated by p14 and Required for Signal Transduction

2002 • 375 citations

An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development

2003 • 361 citations

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

1999 • 337 citations

Role of Raf in Vascular Protection from Distinct Apoptotic Stimuli

2003 • 334 citations

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

2001 • 311 citations

MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

C-TAK1 Regulates Ras Signaling by Phosphorylating the MAPK Scaffold, KSR1

2001 • 277 citations

Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo

2002 • 264 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

Untying the regulation of the Raf-1 kinase

2002 • 174 citations

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene

1996 • 156 citations

Atypical Adenomatous Hyperplasia of the Lung: A Probable Forerunner in the Development of Adenocarcinoma of the Lung

2001 • 147 citations

Mutational activation of c-raf-1 and definition of the minimal transforming sequence.

1990 • 146 citations

Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases

2002 • 146 citations

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells

1996 • 120 citations

Raf-1 Physically Interacts with Rb and Regulates Its Function: a Link between Mitogenic Signaling and Cell Cycle Regulation

1998 • 119 citations

C. elegans ksr-1 and ksr-2 Have Both Unique and Redundant Functions and Are Required for MPK-1 ERK Phosphorylation

2002 • 110 citations

BAY 43-9006: Early Clinical Data in Patients with Advanced Solid Malignancies

2002 • 101 citations

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

2000 • 90 citations

Raf-1 Antagonizes Erythroid Differentiation by Restraining Caspase Activation

2002 • 78 citations

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

2002 • 77 citations

Sensing life: regulation of sensory neuron survival by neurotrophins

2002 • 69 citations

Isoform-Specific Localization of A-RAF in Mitochondria

2000 • 63 citations

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

2002 • 61 citations

A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation

2003 • 52 citations

Novel raf kinase protein–protein interactions found by an exhaustive yeast two-hybrid analysis

2003 • 38 citations

Raf kinases in lung tumor development

2003 • 21 citations