Don't leave the “psych” out of neuropsychology

Helplessness: On Depression, Development, and Death

1975 • 6,201 citations

Précis ofThe neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

1982 • 4,511 citations

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

The rat nervous system

1985 • 3,774 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

The psychology of fear and stress

1988 • 3,188 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

From motivation to action: Functional interface between the limbic system and the motor system

1980 • 2,292 citations

Learned helplessness: Theory and evidence.

1976 • 2,255 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Negative v Positive Schizophrenia

1982 • 2,003 citations

Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study

1983 • 1,954 citations

Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey

1983 • 1,898 citations

Molecular pathology of schizophrenia: more than one disease process?

1980 • 1,877 citations

American Handbook of Psychiatry

1960 • 1,758 citations

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

AN ANATOMICAL STUDY OF CONVERGING SENSORY PATHWAYS WITHIN THE CEREBRAL CORTEX OF THE MONKEY

1970 • 1,701 citations

Learning Theory and Behavior

1962 • 1,634 citations

Learning theory and behavior.

1960 • 1,542 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐B‐hydroxylase as a marker

1975 • 1,454 citations

The validity of animal models of depression

1984 • 1,365 citations

Anxiety and the Anxiety Disorders

1990 • 1,309 citations

The Biochemistry of Affective Disorders

1967 • 1,183 citations

Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics

1978 • 1,173 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Norepinephrine in Depressive Reactions

1965 • 1,127 citations

[Biological psychiatry].

1980 • 1,087 citations

Cortico-cortical connections in the rhesus monkey

1969 • 1,086 citations

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.

1984 • 1,060 citations

Neuroleptics and operant behavior: The anhedonia hypothesis

1982 • 1,021 citations

Emotion

1982 • 986 citations

Frustrative nonreward in partial reinforcement and discrimination learning: Some recent history and a theoretical extension.

1962 • 966 citations

Positron Emission Tomography Reveals Elevated D ₂ Dopamine Receptors in Drug-Naive Schizophrenics

1986 • 935 citations

The problem of the frontal lobe: A reinterpretation

1971 • 892 citations

Basal Ganglia and Limbic System Pathology in Schizophrenia

1985 • 891 citations

Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.

1982 • 888 citations

The amygdalostriatal projection in the rat—an anatomical study by anterograde and retrograde tracing methods

1982 • 884 citations

Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro.

1981 • 871 citations

Efferent connections and nigral afferents of the nucleus accumbens septi in the rat

1978 • 868 citations

Elements of a two-process theory of learning

1975 • 850 citations

Huntington's Chorea

1973 • 845 citations

The prefrontal cortex of the rat. I. cortical projection of the mediodorsal nucleus. II. efferent connections

1969 • 845 citations

The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems

1984 • 815 citations

An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal‐projection (prefrontal) cortex in the rat

1979 • 787 citations

American Handbook of Psychiatry

1976 • 783 citations

Latent inhibition.

1973 • 774 citations

Catecholamine theories of reward: A critical review

1978 • 766 citations

Animal Discrimination Learning

1969 • 750 citations

The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: An anterograde and retrograde-horseradish peroxidase study

1982 • 741 citations

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

1980 • 736 citations

On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine

1977 • 733 citations

An Anatomy of Schizophrenia?

1973 • 721 citations

A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: Evidence from immunohistochemistry combined with retrograde tracing

1980 • 717 citations

Selective 60HDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats

1976 • 706 citations

Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. II. Frontal lobe afferents

1975 • 696 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment

1981 • 645 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

Cortico-striate projections in the rhesus monkey: The organization of certain cortico-caudate connections

1978 • 640 citations

Diagnosis in Schizophrenia and Manic-Depressive Illness

1978 • 635 citations

Handbook of clinical neurology

1969 • 608 citations

Cerebral Metabolic Rates for Glucose in Mood Disorders

1985 • 595 citations

An autoradiographic study of the efferent connections of the preoptic region in the rat

1976 • 583 citations

The pharmacological and anatomical substrates of the amphetamine response in the rat

1975 • 583 citations

Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity

1979 • 576 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Biochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibres in rat brain

1981 • 547 citations

Overview of Recent Research in Depression

1975 • 545 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

A theory of the functional organization of the neostriatum and the neostriatal control of voluntary movement

1983 • 535 citations

Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: Most antidepressants selectively block norepinephrine uptake

1984 • 528 citations

An intricately patterned prefronto‐caudate projection in the rhesus monkey

1977 • 506 citations

Neurobiology of Mood Disorders

1985 • 492 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Structural Abnormalities in the Frontal System in Schizophrenia

1986 • 489 citations

Cholecystokinin innervation of the ventral striatum: A morphological and radioimmunological study

1985 • 485 citations

Carbamazepine in manic-depressive illness: a new treatment

1980 • 485 citations

Possible Etiology of Schizophrenia: Progressive Damage to the Noradrenergic Reward System by 6-Hydroxydopamine

1971 • 480 citations

Pharmacology of mesocortical dopamine neurons.

1983 • 478 citations

Performance of Schizophrenic Patients on Tests Sensitive To Left or Right Frontal, Temporal, or Parietal Function in Neurological Patients

1983 • 467 citations

NEUROBIOLOGY OF MOOD DISORDERS

2017 • 466 citations

Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus

1983 • 464 citations

Organization of the efferent projections of the nucleus accumbens to pallidal, hypothalamic, and mesencephalic structures: A tracing and immunohistochemical study in the cat

1984 • 453 citations

Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens

1984 • 440 citations

Occurrence of neurotensinlike immunoreactivity in subpopulations of hypothalamic, mesencephalic, and medullary catecholamine neurons

1984 • 439 citations

The influence of fatigue on health-related quality of life in patients with Parkinson's disease

2003 • 439 citations

Amygdaloid and basal forebrain direct connections with the nucleus of the solitary tract and the dorsal motor nucleus

1982 • 432 citations

Excitatory amino acid transmission

1987 • 430 citations

Catecholamines in the Brain as Mediators of Amphetamine Psychosis

1972 • 428 citations

Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat

1982 • 424 citations

Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat.

1978 • 421 citations

Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia

1983 • 412 citations

Is the mesocortical dopaminergic system involved in Parkinson disease?

1980 • 412 citations

Speculations on the Functional Anatomy of Basal Ganglia Disorders

1983 • 411 citations

Neural projections from nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat

1983 • 403 citations

The effect of Parkinson's disease on the ability to maintain a mental set.

1985 • 396 citations

Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis.

1965 • 395 citations

Increased Brain Dopamine and Dopamine Receptors in Schizophrenia

1982 • 393 citations

Ventral striatum and ventral pallidum

1982 • 388 citations

The amygdalostriatal projections in the monkey. An anterograde tracing study

1985 • 387 citations

Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity: relationship to schizophrenic attention disorder.

1981 • 385 citations

Specificity of the learned helplessness model of depression

1982 • 383 citations

Deficits in Sensory Gating in Schizophrenic Patients and Their Relatives

1984 • 381 citations

Dopaminergic substrates of amphetamine-induced place preference conditioning

1982 • 381 citations

Cognitive and motor shifting aptitude disorder in Parkinson's disease.

1984 • 376 citations

Self-injection of amphetamine directly into the brain

1983 • 373 citations

Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats

1976 • 371 citations

Chemotherapy in Psychiatry

2012 • 358 citations

The symptoms of major depressive illness

1981 • 358 citations

Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains

1978 • 351 citations

Bimodal Distribution of Dopamine Receptor Densities in Brains of Schizophrenics

1984 • 347 citations

A note on the connections and development of the nucleus accumbens

1975 • 347 citations

Functional Studies of the Central Catecholamines

1982 • 344 citations

Neurobiology of Cerebrospinal Fluid.

1981 • 343 citations

Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics

1986 • 341 citations

Excitatory amino acid projections to the nucleus accumbens septi in the rat: A retrograde transport study utilizingd[3H]aspartate and [3H]GABA

1987 • 339 citations

Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?

1973 • 336 citations

Physiology, Emotion and Psychosomatic Illness

1973 • 335 citations

Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the rat

1979 • 328 citations

Evidence for a projection from the lateral preoptic area and substantia innominata to the ‘mesencephalic locomotor region’ in the rat

1984 • 326 citations

SKIN CONDUCTANCE ORIENTING ACTIVITY IN A HETEROGENEOUS SAMPLE OF SCHIZOPHRENICS

1972 • 325 citations

Striatal inhomogeneities and basal ganglia function

1986 • 323 citations

Evidence for the participation of nigrotectal γ-aminobutyrate-containing neurones in striatal and nigral-derived circling in the rat

1982 • 318 citations

Typical and atypical antidepressants. Molecular mechanisms.

1982 • 315 citations

Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.

1986 • 309 citations

Effect of frontal cortex ablation on striatal glutamic acid level in rat

1977 • 306 citations

Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography

1985 • 299 citations

Euphorigenic drugs: effects on the reward pathways of the brain.

1979 • 299 citations

Monoamine Oxidase Inhibitors

1979 • 298 citations

Response to stress of mesocortico-frontal dopaminergic neurones in rats after long-term isolation

1980 • 296 citations

DISTRIBUTION OF CEREBRAL ACTIVITY IN CHRONIC SCHIZOPHRENIA

1974 • 293 citations

Receptor Adaptations to Centrally Acting Drugs

1981 • 293 citations

Long-Term Treatment with Lithium Prevents the Development of Dopamine Receptor Supersensitivity

1978 • 287 citations

The origin and distribution of dopamine-containing afferents to the rat frontal cortex

1978 • 285 citations

The action of dopamine on neurones of the caudate nucleus

1967 • 280 citations

Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity

1985 • 279 citations

Effect of inescapable shock on subsequent escape performance: Catecholaminergic and cholinergic mediation of response initiation and maintenance

1979 • 277 citations

Current Developments in Psychopharmacology

1981 • 275 citations

Clinical pharmacology of imipramine and related antidepressant compounds.

1967 • 274 citations

Brain reward systems and abuse

1988 • 274 citations

Conditioned place preference from intra-accumbens but not intra-caudate amphetamine injections

1983 • 273 citations

Caudate nucleus neurones: correlation of the effects of substantia nigra stimulation with iontophoretic dopamine

1970 • 271 citations

Central Dopamine Turnover in Schizophrenic Syndromes

1974 • 268 citations

Dopamine and depression: A review of recent evidence. I. Empirical studies

1983 • 267 citations

Norepinephrine in Chronic Paranoid Schizophrenia: Above-Normal Levels in Limbic Forebrain

1978 • 265 citations

The neural substrates for the motor-activating properties of psychostimulants: A review of recent findings

1986 • 262 citations

Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats

1984 • 262 citations

Ascending catecholamine pathways and amphetamine-induced locomotor activity: Importance of dopamine and apparent non-involvement of norepinephrine

1975 • 259 citations

Frontal lobe dysfunctions in schizophrenia—I. Eye movement impairments

1984 • 259 citations

Regular Induction of Hypomania by L-Dopa in “Bipolar” Manic-depressive Patients

1971 • 257 citations

Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system

1980 • 256 citations

The Limbic System: Functional Organization and Clinical Disorders

1987 • 256 citations

Pimozide Blocks Establishment But Not Expression of Amphetamine-Produced Environment-Specific Conditioning

1983 • 256 citations

The neurology of schizophrenia

1987 • 255 citations

INCREASED BRAIN DOPAMINE AND REDUCED GLUTAMIC ACID DECARBOXYLASE AND CHOLINE ACETYL TRANSFERASE ACTIVITY IN SCHIZOPHRENIA AND RELATED PSYCHOSES

1977 • 254 citations

GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function

1981 • 253 citations

Relationship between the locomotor hyperactivity induced by A10 lesions and the destruction of the frontocortical dopaminergic innervation in the rat

1978 • 253 citations

Psychopharmacology: A Generation of Progress

1978 • 252 citations

Converging projections from the mediodorsal thalamic nucleus and mesencephalic dopaminergic neurons to the neocortex in three species

1978 • 250 citations

Neurotransmitter Receptors in Frontal Cortex of Schizophrenics

1979 • 249 citations

Psychiatric symptoms in Parkinsonism.

1970 • 246 citations

Isolation and Characterization of a Compound from the Urine of Schizophrenics

1962 • 246 citations

Neurophysiological studies of sensory gating in rats: Effects of amphetamine, phencyclidine, and haloperidol

1986 • 243 citations

Differential effects of microinjections of d-amphetamine into the nucleus accumbens or the caudate putamen on the rat's ability to ignore an irrelevant stimulus.

1982 • 243 citations

Effect of 6‐Hydroxydopamine Lesions of the Medial Prefrontal Cortex on Neurotransmitter Systems in Subcortical Sites in the Rat

1980 • 242 citations

Current Developments in Psychopharmacology

1978 • 242 citations

Psychiatric disturbances in Parkinson's disease.

1972 • 240 citations

Anxiety and the anxiety disorders

1990 • 238 citations

Regional Brain Glucose Metabolism in Chronic Schizophrenia

1984 • 237 citations

The Phenomenology of Mania

1973 • 235 citations

Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area

1985 • 231 citations

Parkinson's disease with depression

1986 • 231 citations

Neuroleptic-induced attenuation of brain stimulation reward in rats.

1978 • 229 citations

Decreased intracranial self-stimulation after neuroleptics or 6-hydroxydopamine: Evidence for mediation by motor deficits rather than by reduced reward

1976 • 227 citations

Behavioral approaches to brain research

1983 • 227 citations

Anatomical disassociation of amphetamine's rewarding and aversive effects: An intracranial microinjection study

1986 • 215 citations

Parkinson's disease

1985 • 214 citations

Excitatory nature of dopamine in the nigro-caudate pathway

1976 • 212 citations

Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus: effects on locomotor activity mediated by nucleus accumbens-ventral pallidal circuitry

1987 • 211 citations

Interactions between dopamine and amino acid-induced excitation and inhibition in the striatum

1986 • 211 citations

Kindling of the mesolimbic dopamine system

1978 • 210 citations

Neurobiological substrates of tardive dyskinesia: the GABA hypothesis

1984 • 209 citations

Neuroanatomical focus for morphine and enkaphalin-induced hypermotility

1977 • 209 citations

Neurophysiological studies of sensory gating in mania: comparison with schizophrenia.

1983 • 207 citations

INCREASED DOPAMINE CONCENTRATION IN LIMBIC AREAS OF BRAIN FROM PATIENTS DYING WITH SCHIZOPHRENIA

1979 • 203 citations

Interactions between d-Ala-Met-enkephalin, A10 dopaminergic neurones, and spontaneous behaviour in the rat

1980 • 203 citations

Depression: A Psychobiological Synthesis

1985 • 203 citations

Recurrent inhibition in the rat neostriatum

1980 • 203 citations

Chlorpromazie and Dopamine: Conformational Similarities that Correlate with the Antischizophrenic Activity of Phenothiazine Drugs

1971 • 199 citations

Frontal lobe dysfunctions in schizophrenia—II. impairments of psychological and brain functions

1984 • 197 citations

Deficits of escape performance following catecholamine depletion: Implications for behavioral deficits induced by uncontrollable stress

1979 • 196 citations

Dopamine and the Pathophysiology of Dyskinesias Induced by Antipsychotic Drugs

1980 • 195 citations

Parkinson's disease and dementia

1987 • 194 citations

The mesocortico-prefrontal dopaminergic neurons

1984 • 194 citations

Mesocortical dopamine neurons. Lack of autoreceptors modulating dopamine synthesis.

1981 • 194 citations

Phenomenology and Treatment of Anxiety

1980 • 192 citations

The comparative distribution of enkephalin, dynorphin and substance P in the human globus pallidus and basal forebrain

1985 • 188 citations

Depression in Patients with Parkinsonism

1976 • 187 citations

Brain catecholamines in schizophrenia — a good case for noradrenaline

1982 • 186 citations

Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.

1980 • 182 citations

Evidence that an accumbens to subpallidal GABAergic projection contributes to locomotor activity

1983 • 182 citations

L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.

1970 • 181 citations

Kindling mechanisms: Current progress on an experimental epilepsy model

1986 • 179 citations

Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness

1984 • 179 citations

Nucleus accumbens to globus pallidus GABA projection: Electrophysiological and iontophoretic investigations

1980 • 179 citations

Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients: normalization after neuroleptic treatment

1982 • 176 citations

Disappearance of hoarding behavior after 6-hydroxydopamine lesions of the mesolimbic dopamine neurons and its reinstatement with l-dopa.

1985 • 173 citations

Unipolar and Bipolar Affective Illness

1971 • 172 citations

Basic Mechanisms in the Action of Lithium

1983 • 172 citations

Variability of hormonal responses to a series of neuroendocrine challenges in depressed patients

1982 • 172 citations

EMOTION: Theory, Research, and Experience

1986 • 171 citations

Effects of a Dopamine Agonist Piribedil in Depressed Patients

1978 • 169 citations

Neuropsychopharmacology and the Affective Disorders

1969 • 168 citations

Iontophoretically applied dopamine depolarizes and hyperpolarizes the membrane of cat caudate neurons

1980 • 168 citations

Hypersomnia and Manic-Depressive Disease

1972 • 167 citations

Structural Brain Deficits in Schizophrenia

1981 • 167 citations

Cholecystokinin potentiates dopamine-mediated behaviors: evidence for modulation specific to a site of coexistence

1985 • 166 citations

Haloperidol-induced presynaptic dopamine supersensitivity is blocked by chronic lithium

1978 • 166 citations

Cholecystokinin potentiates dopamine-mediated behaviors: evidence for modulation specific to a site of coexistence.

1985 • 165 citations

3H-flupenthixol binding in post-mortem brains of schizophrenics: Evidence for a selective increase in dopamine D2 receptors

1981 • 165 citations

The islands of Calleja complex of rat basal forebrain. III. Histochemical evidence for a Striatopallidal system

1983 • 164 citations

CONGENITAL DOPAMINE-BETA-HYDROXYLASE DEFICIENCY

1987 • 164 citations

Psychiatric Implications of Psychomotor Epilepsy

1966 • 164 citations

Neurotensin microinjection into the nucleus accumbens antagonizes dopamine-induced increase in locomotion and rearing

1984 • 163 citations

Nucleus accumbens to globus pallidus GABA projection subserving ambulatory activity

1980 • 162 citations

Electrophysiological evidence for involvement of cyclic adenosine monophosphate in dopamine responses of caudate neurons

1974 • 162 citations

The Basal ganglia : structure and function

1984 • 161 citations

Severe Depressive Mood Changes Following Slow-release Intramuscular Fluphenazine Injection

1969 • 157 citations

Further observations on the effect of repeated electroconvulsive shock on the behavioural resposes of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine

1977 • 155 citations

Catecholamine hypothesis of affective disorders

1969 • 153 citations

The Neurology of schizophrenia

1986 • 152 citations

Motor Activity and Affective Illness

1985 • 152 citations

An Excitant Amino Acid Projection from the Medial Prefrontal Cortex to the Anterior Part of Nucleus Accumbens in the Rat

1985 • 151 citations

Intellectual changes in patients with MPTP‐induced parkinsonism

1985 • 149 citations

Interactions between neuropeptides and dopamine neurons in the ventromedial mesencephalon

1985 • 148 citations

Clinical trials with amphetamine-blocking drugs.

1972 • 147 citations

The unipolar–bipolar distinction in the depressive disorders.

1978 • 147 citations

Phenomenology and treatment of anxiety

1979 • 144 citations

Dopamine and depression: A review of recent evidence. III. The effects of antidepressant treatments

1983 • 144 citations

Brain Reward Systems and Abuse

1987 • 143 citations

Pathologic Correlates of Dementia in Parkinson's Disease

1986 • 141 citations

The Neurobiological Substrates of Depression in Parkinson’s Disease: A Hypothesis

1984 • 141 citations

Modulation of dopaminergic activity in the nucleus accumbens following facilitation or blockade of the dopaminergic transmission in the amygdala: a study by in vivo differential pulse voltammetry

1985 • 140 citations

Abnormal distribution of cerebral activity in chronic schizophrenia

1975 • 139 citations

Biologic Heterogeneity and Psychiatric Research

1979 • 139 citations

Responses of intracellularly recorded cortical neurons to the iontophoretic application of dopamine

1982 • 139 citations

The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus

1981 • 137 citations

Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide

1980 • 137 citations

The distribution and pattern of axon branching of pyramidal tract cells

1973 • 133 citations

The effects of preexposure to a nonattended stimulus on subsequent learning: Latent inhibition in adults

1975 • 133 citations

Functions of the basal ganglia

1985 • 132 citations

Cholinergic Challenges in Affective Illness

1981 • 132 citations

Hormone release in depressed patients before and after recovery

1977 • 131 citations

Antidepressant drugs affect dopamine uptake

1975 • 131 citations

Brain reward circuitry: A case for separate systems

1984 • 130 citations

Tritiated LSD Binding in Frontal Cortex in Schizophrenia

1981 • 125 citations

Two syndromes in schizophrenia?

1982 • 118 citations

Dopamine β-Hydroxylase Activity in Brains of Chronic Schizophrenic Patients

1975 • 117 citations

Symptom Differences in Schizophrenia with Good and Poor Prognosis

1972 • 117 citations

Depressive symptoms in Parkinson patients referred for thalamotomy.

1967 • 116 citations

Substantia innominata: Critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat

1984 • 115 citations

Monoamines and peptides in cerebral cortex — contrasting principles of cortical organization

1983 • 114 citations

Influence of ventral mesencephalic lesions on various spontaneous and conditioned behaviors in the rat

1969 • 114 citations

I. Parkinson's disease: Studies with an animal model

1984 • 111 citations

The enigma of the basal ganglia and movement

1980 • 108 citations

Dopaminergic nerve endings in the neostriatum of the rat—1. Identification by intracerebral injections of 5-hydroxydopamine

1978 • 108 citations

Brain Organization in Schizophrenia

1986 • 108 citations

Acute Mania

1975 • 107 citations

Nomifensine: A potent dopaminergic agonist of antiparkinson potential

1975 • 107 citations

A study of an ascending nigro-caudate pathway

1972 • 106 citations

Neuroendocrine correlates in neurology and psychiatry

1980 • 106 citations

Studies on the pharmacology of neurones in the nucleus accumbens of the rat

1976 • 104 citations

Affective disorder

1965 • 102 citations

Influence of cholecystokinin on central monoaminergic pathways

1983 • 99 citations

Evidence of dopamine involvement in the effect of repeated treatment with various antidepressants in the behavioural ‘despair’ test in rats

1985 • 99 citations

[Functions of the basal ganglia].

1982 • 99 citations

Learning in a Marine Snail

1983 • 98 citations

Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants

1983 • 96 citations

Effects of chronic amphetamine or reserpine on self-stimulation responding: Animal model of depression?

1980 • 96 citations

The origin of cholecystokinin terminals in the basal forebrain of the rat: Evidence from immunofluorencence and retrograde tracing

1983 • 96 citations

PARKINSON'S DISEASE

1922 • 96 citations

The Iowa 500

1972 • 95 citations

Effects of apomorphine and haloperidol on the acoustic startle response in rats

1976 • 94 citations

Physiology, emotion & psychosomatic illness

1975 • 94 citations

Increases in intracranial self-stimulation in the posterior hypothalamus following unilateral lesions in the locus coeruleus

1976 • 93 citations

Neurotransmitters in the Basal Ganglia

1984 • 93 citations

Escape deficits induced by uncontrollable stress: Antagonism by dopamine and norepinephrine agonists

1980 • 93 citations

The neural substrates of apomorphine-stimulated locomotor activity following denervation of the nucleus accumbens

1984 • 92 citations

Neuropsychopharmacology and the Affective Disorders

1969 • 92 citations

Separate neural substrates of the locomotor-activating properties of amphetamine, heroin, caffeine and Corticotropin Releasing Factor (CRF) in the rat

1985 • 91 citations

Behavioral effects of LSD in the cat: Proposal of an animal behavior model for studying the actions of hallucinogenic drugs

1977 • 91 citations

Biology of Schizophrenia Subtypes: A Review and Proposal for Method of Study

1979 • 91 citations

Gating of auditory evoked responses in normal college students

1986 • 91 citations

Neuroscience and psychiatry: marriage or coexistence?

1986 • 90 citations

Effects of amphetamines on regional tryptophan hydroxylase activity and synaptosomal conversion of tryptophan to 5-hydroxytryptamine in rat brain.

1974 • 90 citations

Hyporesponsivity of Chronic Schizophrenic Patients to Dextroamphetamine

1976 • 89 citations

Effects of clorgyline and pargyline on deaminated metabolites of norepinephrine, dopamine and serotonin in human cerebrospinal fluid

1979 • 88 citations

A Neuroendocrine Test Battery in Bipolar Patients and Healthy Subjects

1983 • 88 citations

Caudate nucleus and programming behaviour in cats: Role of dopamine in switching motor patterns

1984 • 88 citations

α2-Adrenergic Receptor Function in Depression

1986 • 87 citations

Non-DA prefronto-cortical efferents modulate D1 receptors in the nucleus accumbens

1984 • 84 citations

Structure and function: Brain electrical activity mapping and computed tomography in schizophrenia

1985 • 83 citations

Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. II. No effect on denervation or neuroleptic-induced supersensitivity

1982 • 82 citations

The activities of brain dopamine-?-hydroxylase and catechol-O-methyl transferase in schizophrenics and controls

1978 • 81 citations

Electrophysiological evidence that the mediodorsal nucleus of the thalamus is a relay between the ventral pallidum and the medial prefrontal cortex in the rat

1985 • 80 citations

Electroconvulsive Therapy

1985 • 80 citations

Antidepressants: neurochemical, behavioural and clinical perspectives

1982 • 80 citations

A PSYCHOBIOLOGICAL APPROACH TO AFFECTIVE ILLNESS

1973 • 79 citations

Cocaine: Excitatory effects on sensorimotor reactivity measured with acoustic startle

1985 • 79 citations

The Effects of Ceruletide in Schizophrenia

1984 • 79 citations

A neuronal receptor sensitivity mechanism in affective illness (a review of evidence).

1977 • 78 citations

Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures

1985 • 78 citations

The inhibitory action of dopamine on neurones of the caudate nucleus

1967 • 77 citations

Catecholamines. Part C: Neuropharmacology and central nervous system—Therapeutic aspects

1985 • 75 citations

COMMON CHARACTERISTICS OF EPILEPSY AND SCHIZOPHRENIA: CLINICAL OBSERVATION AND DEPTH ELECTRODE STUDIES

1962 • 75 citations

The basal ganglia and the control of movement

1981 • 73 citations

CSF dopamine levels correlate with extraversion in depressed patients

1986 • 73 citations

Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain stimulation reward

1984 • 71 citations

Thalamocortical synapses with corticothalamic projection neurons in mouse SmI cortex: Electron microscopic demonstration of a monosynaptic feedback loop

1981 • 71 citations

Differential anatomical location of [³H]‐N,n‐propylnorapomorphine and [³ H]‐spiperone binding sites in the striatum and substantia nigra of the rat

1983 • 71 citations

Behavioural and biochemical consequences of persistent overstimulation of mesolimbic dopamine systems in the rat

1982 • 70 citations

Effects of electroconvulsive therapy on mood, parkinsonism, and tardive dyskinesia in a depressed patient: ECT and dopamine systems.

1983 • 69 citations

GABA and the basal ganglia

1981 • 69 citations

Regenerative potentials in rat neostriatal neurons in an in vitro slice preparation

1985 • 68 citations

Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. I. Locomotor activity and behavioral supersensitivity

1982 • 67 citations

Major Depression and Carbon Monoxide-Induced Parkinsonism

1985 • 67 citations

Effects of sulpiride and chlorpromazine on autistic and positive psychotic symptoms in schizophrenic patients ?relationship to drug concentrations

1985 • 65 citations

Ethological study of facial behavior in nonparanoid and paranoid schizophrenic patients

1987 • 64 citations

Facilitation of spontaneous and learned spatial behaviours following 6-hydroxydopamine lesions of the lateral septum: a cholinergic hypothesis

1985 • 63 citations

Research in the Psychobiology of Human Behavior

1980 • 63 citations

Projections from nucleus accumbens to globus pallidus and substantia nigra in the rat

1978 • 63 citations

The effect of 6-ohda lesions of the lateral septum on schedule-induced polydipsia

1985 • 63 citations

Locomotor behavior following kindling in three different brain sites

1985 • 62 citations

No evidence of antipsychotic effect of caerulein in schizophrenic patients free of neuroleptics: a double-blind cross-over study.

1984 • 62 citations

Prefrontal cortex dysfunction as a common factor in psychosis

1985 • 62 citations

The effects of pimozide and phenoxybenzamine pretreatments on amphetamine and apomorphine potentiation of the acoustic startle response in rats

1978 • 61 citations

Lithium effects on haloperidol-induced pre- and postsynaptic dopamine receptor supersensitivity

1980 • 61 citations

Chemistry of Mood and Emotion

1980 • 59 citations

Effect of chronic desipramine treatment on adrenoceptor modulation of [3H]dopamine release from rat nucleus accumbens slices

1985 • 59 citations

Effects of neuroleptic drugs, clonidine and lithium on the expression of conditioned behavioral excitation in rats

1987 • 59 citations

Differential effects of striatal injections of dopaminergic, cholinergic and GABAergic drugs upon swimming behavior of rats

1986 • 58 citations

Parkinson's disease

1958 • 58 citations

Depression. A Psychobiological Synthesis

1986 • 53 citations

Ceruletide for schizophrenia: A double-blind study

1985 • 52 citations

Concomitant administration of haloperidol and lithium carbonate in acute mania.

1977 • 52 citations

The effects of d-amphetamine, alpha-flupenthixol, and mesolimbic dopamine depletion on a test of attentional switching in the rat

1986 • 51 citations

AMERICAN PSYCHOLOGICAL ASSOCIATION ANNUAL MEETING

1982 • 51 citations

Double blind controlled trials of cholecystokinin octapeptide in neuroleptic-refractory schizophrenia

1987 • 49 citations

Genetic independence of manic‐depression and schizophrenia

1981 • 49 citations

A Dopamine‐dependent Restitutive System for the Maintenance of Mental Normalcy

1986 • 49 citations

The effects of chronic lithium on behavioral and biochemical indices of dopamine receptor supersensitivity in the rat

1984 • 48 citations

Research in the Psychobiology of Human Behavior

1979 • 47 citations

Various mental behavioral disorders in Parkinson's disease, primary degenerative senile dementia, and multiple infarction dementia

1983 • 46 citations

Homovanillic acid in caudate and pre-frontal cortex following acute and chronic neuroleptic administration

1986 • 45 citations

Influence of lithium on biochemical manifestations of striatal dopamine target cell supersensitivity induced by prolonged haloperidol treatment

1983 • 45 citations

Behavioral deficits induced by low doses of apomorphine in rats: Evidence for a motivational and cognitive dysfunction which discriminates among neuroleptic drugs

1986 • 44 citations

Muscarinic cholinergic influences on ACTH and β-endorphin release mechanisms in human subjects

1981 • 43 citations

Effect of Excitotoxin Lesions in the Medial Prefrontal Cortex on Cortical and Subcortical Catecholamine Turnover in the Rat

1986 • 43 citations

Neurobiology of Cerebrospinal Fluid: 1

1981 • 43 citations

Levodopa and cholinergic hypersensitivity in Parkinson's disease

1972 • 42 citations

The interrelationship between superior colliculus and substantia nigra pars reticulata in programming movements of cats: A follow-up

1987 • 42 citations

Partial protection by desmethylimipramine of the mesocortical dopamine neurones from the neurotoxic effect of 6-hydroxydopamine injected in ventral mesencephalic tegmentum. The role of noradrenergic innervation

1986 • 42 citations

Brain dopamine and noradrenaline levels in rats submitted to four different aversive behavioral tests

1979 • 41 citations

Lithium prevents adaptation of brain dopamine systems to haloperidol in schizophrenic patients

1983 • 40 citations

Narcotic Antagonists in Schizophrenia: A Methodological Review

1983 • 40 citations

Chronic lithium administration alters behavioral recovery from nigrostriatal injury: Effects on neostriatal [3H]spiroperidol binding sites

1983 • 38 citations

Left hemispheric density deficits in chronic schizophrenia.

1984 • 37 citations

DOPAMINERGIC MECHANISMS

1976 • 37 citations

Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supresensitivity following haloperidol and reserpine

1983 • 35 citations

The interrelationship between superior colliculus and substantia nigra pars reticulata in programming movements of cats

1986 • 34 citations

Supersensitive endocrine response to physostigmine in dopamine-depleted rats: A model of depression?

1986 • 34 citations

Schizophrenia: no longer a functional psychosis

1986 • 33 citations

Effects of chronic dietary lithium on behavioral indices of dopamine denervation supersensitivity in the rat.

1985 • 31 citations

From animals models to clinical testing — promises and pitfalls

1983 • 31 citations

A high-dose, double-blind study of ceruletide in the treatment of schizophrenia

1985 • 31 citations

Lithium does not interact, with haloperidol in the dopaminergic pathways of the rat brain

1984 • 30 citations

Regional Distribution of Catecholamines in Nucleus Accumbens of the Rabbit

1983 • 29 citations

The Basal Ganglia

1984 • 29 citations

Decreased phosphorylation of synaptic glycoproteins following hippocampal kindling

1986 • 28 citations

Genetic Evidence for the Existence of Subgroups of the Schizophrenic Syndrome

1979 • 28 citations

Central catecholamines, cognitive impairment, and affective state in elderly schizophrenics and controls

1987 • 27 citations

Lidocaine kindling is accompanied by an increase in apomorphine stereotypy and mesolimbic dopamine D2 receptor density.

1985 • 27 citations

Sequential changes of skin conductance activity in rats after intraventricular administration of 6-hydroxydopamine

1986 • 27 citations

The effect of single and repeated electroconvulsive shock (ECS) on locomotor activity in rats

1983 • 27 citations

Neuroendocrine strategies in affective disorders

1983 • 26 citations

Functional effects of local injections of dopamine and analogs into the neostriatum and nucleus accumbens.

1977 • 26 citations

Coming of age in neuroscience

1986 • 25 citations

Morphine and specific changes in the sensitivity of noradrenergic receptors within the “limbic” part of the feline caudate nucleus: A behaviour study

1985 • 25 citations

CHOLECYSTOKININ

1984 • 24 citations

Current biochemical research in schizophrenia.

1966 • 23 citations

Long-term Receptor Regulation Induced by Denervation of Heterologous Afferent Fibers: Functional Significance

1987 • 23 citations

No change in neostriatal D-2 dopamine receptors after NMDA lesions of rat prefrontal cortex

1986 • 22 citations

Analysis of Physiological Mechanism in Psychopharmacology

1984 • 22 citations

Chemotherapy in Psychiatry

1978 • 16 citations