Susceptibility of Cyclooxygenase-2-Deficient Mice to Pulmonary Fibrogenesis

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

1995 • 1,133 citations

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 • 1,102 citations

Prostaglandin Endoperoxide H Synthases-1 and -2

1996 • 721 citations

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

1990 • 581 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Arachidonic Acid Is Preferentially Metabolized by Cyclooxygenase-2 to Prostacyclin and Prostaglandin E2

1999 • 295 citations

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

2000 • 274 citations

Transfer of Tumor Necrosis Factor-α to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-β1 and Myofibroblasts

1998 • 263 citations

Cyclooxygenase-2 Deficiency Results in a Loss of the Anti-Proliferative Response to Transforming Growth Factor-β in Human Fibrotic Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

2001 • 248 citations

Cyclooxygenase knockout mice

1999 • 224 citations

Allergic lung responses are increased in prostaglandin H synthase–deficient mice

1999 • 204 citations

TNF-α Receptor Knockout Mice Are Protected from the Fibroproliferative Effects of Inhaled Asbestos Fibers

1998 • 146 citations

Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

1999 • 144 citations

Quantitative Assessment of Lung Pathology in Idiopathic Pulmonary Fibrosis

1991 • 116 citations

Tumor Necrosis Factor-α Inversely Regulates Prostaglandin D2 and Prostaglandin E2 Production in Murine Macrophages

1997 • 98 citations

Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor‐κB activation in J774 macrophages

1998 • 96 citations

Different Expression of TNF- α Receptors and Prostaglandin E₂Production in Normal and Fibrotic Lung Fibroblasts

2000 • 94 citations

Airway Inflammation and Responsiveness in Prostaglandin H Synthase–Deficient Mice Exposed to Bacterial Lipopolysaccharide

2001 • 86 citations

Cyclooxygenase Inhibition Increases Interleukin 5 and Interleukin 13 Production and Airway Hyperresponsiveness in Allergic Mice

2000 • 82 citations

Boilermakers?? Bronchitis

1984 • 82 citations

Airway fibrosis in rats induced by vanadium pentoxide

2000 • 80 citations

Regulation of connective tissue growth factor expression by prostaglandin E₂

1999 • 69 citations

Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice.

1997 • 64 citations

Structural studies of hemoglobin Saint Etienne β 92 (F8) his → GLN: A new abnormal hemoglobin with loss of β proximal histidine and absence of heme on the β chains

1972 • 62 citations

Induction of PDGF receptor-α in rat myofibroblasts during pulmonary fibrogenesis in vivo

1998 • 56 citations

The effect of PGE2 on the activation of quiescent lung fibroblasts

1987 • 55 citations

Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions.

1999 • 47 citations

Differential regulation of cytokine and cytokine receptor genes by PAF, LTB4 and PGE2.

1993 • 46 citations

Prostaglandin-E₂Counteracts Interleukin-1 β –Stimulated Upregulation of Platelet-Derived Growth Factor α -Receptor on Rat Pulmonary Myofibroblasts

1999 • 33 citations

Decreased prostaglandin E₂ synthesis by lung fibroblasts isolated from rats with bleomycin‐induced lung fibrosis

1999 • 30 citations

Relative Activities of Retrovirally Expressed Murine Prostaglandin Synthase-1 and -2 Depend on Source of Arachidonic Acid

1996 • 27 citations