Prostaglandin-E₂Counteracts Interleukin-1 β –Stimulated Upregulation of Platelet-Derived Growth Factor α -Receptor on Rat Pulmonary Myofibroblasts

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

1995 • 1,133 citations

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 • 1,102 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Prostaglandin and thromboxane biosynthesis

1991 • 444 citations

Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

1995 • 385 citations

Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 • 376 citations

Bronchoprotective role for endogenous prostaglandin E2

1995 • 255 citations

Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase.

1985 • 219 citations

Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins.

1990 • 130 citations

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1997 • 118 citations

Differential Proliferation of Rat Lung Fibroblasts Induced by the Platelet-derived Growth Factor-AA, -AB, and -BB Isoforms Secreted by Rat Alveolar Macrophages

1991 • 103 citations

Commentary Signal transduction by the receptors for platelet-derived growth factor

1990 • 87 citations

Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts.

1995 • 76 citations

Basic fibroblast growth factor modulates the mitogenic potency of the platelet-derived growth factor (PDGF) isoforms by specific upregulation of the PDGF alpha receptor in vascular smooth muscle cells.

1992 • 71 citations

Alveolar macrophages stimulated with titanium dioxide, chrysotile asbestos, and residual oil fly ash upregulate the PDGF receptor-alpha on lung fibroblasts through an IL-1beta-dependent mechanism.

1997 • 67 citations

Transforming growth factor-β stimulation of lung fibroblast prostaglandin E2 production

1989 • 66 citations

Proliferative effects of insulin and epidermal growth factor on mouse mammary epithelial cells in primary culture. Enhancement by hydroxyeicosatetraenoic acids and synergism with prostaglandin E2.

1988 • 57 citations

Interstitial pulmonary macrophages produce platelet-derived growth factor that stimulates rat lung fibroblast proliferation in vitro

1992 • 56 citations

Transforming growth factor beta 1 downregulates the platelet-derived growth factor alpha-receptor subtype on human lung fibroblasts in vitro.

1995 • 56 citations

Bronchial epithelial cells regulate fibroblast proliferation

1995 • 56 citations

Induction of PDGF receptor-α in rat myofibroblasts during pulmonary fibrogenesis in vivo

1998 • 56 citations

The effect of PGE2 on the activation of quiescent lung fibroblasts

1987 • 55 citations

Interleukin 1 beta (IL-1 beta) and the IL-1 beta-alpha 2-macroglobulin complex upregulate the platelet-derived growth factor alpha-receptor on rat pulmonary fibroblasts.

1995 • 53 citations

Basic fibroblast growth factor induces expression of the PDGF receptor-alpha on human bronchial smooth muscle cells

1996 • 45 citations

Changes in Expression of 15-Lipoxygenase and Prostaglandin-H Synthase during Differentiation of Human Tracheobronchial Epithelial Cells

1998 • 45 citations

Lipopolysaccharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms.

1996 • 43 citations

Antiproliferative effect of prostaglandin E2 in cultured guinea pig tracheal smooth muscle cells

1994 • 38 citations

Pulmonary fibrogenesis after three consecutive inhalation exposures to chrysotile asbestos.

1996 • 37 citations

Positive and negative regulation of cell proliferation through prostaglandin receptors in NIH-3T3 cells

1996 • 35 citations

Role of nuclear factor-kappa B and mitogen-activated protein kinase signaling pathways in IL-1 beta-mediated induction of alpha-PDGF receptor expression in rat pulmonary myofibroblasts.

1998 • 28 citations

Obligatory action of polypeptide growth factors for the IL-1-mediated prostaglandin E2 production in fibroblasts. Potential role of growth factors in modulation of tissue response to IL-1.

1990 • 14 citations