Sequential Operation of Ceramide Synthesis and ICE Cascade in CPT-11-Initiated Apoptotic Death Signaling

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

The Fas Death Factor

1995 • 4,070 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1991 • 1,094 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

1993 • 363 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

1995 • 295 citations

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

1994 • 267 citations

CrmA, a Poxvirus-encoded Serpin, Inhibits Cytotoxic T-lymphocyte-mediated Apoptosis

1995 • 207 citations

Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

1996 • 165 citations

Aspartate-Based Inhibitor of Interleukin-1β-Converting Enzyme Prevents Antitumor Agent-Induced Apoptosis in Human Myeloid Leukemia U937 Cells

1995 • 151 citations

DNA topoisomerase II: A primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy

1987 • 139 citations

Apoptotic cell death induced by intracellular proteolysis.

1994 • 124 citations

Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract.

1996 • 104 citations

Topoisomerase inhibitors induce apoptosis in thymocytes

1993 • 87 citations

Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle.

1996 • 72 citations

Chemotherapeutic Agent CPT-11 Induces the New Expression of the Apoptosis Initiator to the Cytoplasm

1996 • 22 citations

Effect of neonatal exposure to des in fas and BCL-2 expression in the adult mouse vagina and approach to the DES syndrome

1996 • 9 citations

Involvement of CPP32/Yama-like protease in CPT-11-induced death signal transduction pathway

1996 • 6 citations