Induction of apoptotic cell death in hen granulosa cells by ceramide.

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Important Advances in Oncology

1991 • 768 citations

Ovarian Follicle Atresia: A Hormonally Controlled Apoptotic Process*

1994 • 728 citations

INVOLVEMENT OF APOPTOSIS IN OVARIAN FOLLICULAR ATRESIA AND POSTOVULATORY REGRESSION

1991 • 650 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Signal transduction through lipid second messengers

1996 • 496 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels.

1995 • 356 citations

Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation

1993 • 348 citations

Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I.

1994 • 346 citations

Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism.

1992 • 336 citations

Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles.

1995 • 334 citations

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

1993 • 305 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER

1996 • 262 citations

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

1994 • 205 citations

Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.

1995 • 197 citations

Stage of Ovarian Follicular Development Associated with the Initiation of Steroidogenic Competence in Avian Granulosa Cells1

1991 • 196 citations

Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

1993 • 179 citations

Ceramide: a signal for apoptosis or mitogenesis?

1995 • 173 citations

The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation

1994 • 152 citations

Ceramide Mediates the Apoptotic Response of WEHI 231 Cells to Anti-immunoglobulin, Corticosteroids and Irradiation

1994 • 129 citations

Susceptibility of avian ovarian granulosa cells to apoptosis is dependent upon stage of follicle development and is related to endogenous levels of bcl-xlong gene expression.

1996 • 115 citations

Tumor Necrosis Factor-α Gene Expression in Mouse Oocytes and Follicular Cells1

1993 • 104 citations

Growth Hormone Suppression of Apoptosis in Preovulatory Rat Follicles and Partial Neutralization by Insulin-Like Growth Factor Binding Protein1

1995 • 101 citations

Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system.

1994 • 100 citations

Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle.

1995 • 98 citations

Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis.

1996 • 71 citations

Vasoactive intestinal peptide-mediated suppression of apoptosis in the ovary: potential mechanisms of action and evidence of a conserved antiatretogenic role through evolution.

1995 • 67 citations

Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells.

1995 • 66 citations

Inhibition of ceramide pathway does not affect ability of TNF-alpha to activate nuclear factor-kappa B.

1994 • 47 citations

Decreased protein kinase C activity is associated with programmed cell death (apoptosis) in freshly isolated rat hepatocytes

1992 • 46 citations

Influence of Tumor Necrosis Factor Alpha on Intracellular Ca2+ in Hen Granulosa Cells in Vitro during Follicular Development1

1995 • 12 citations

Protein kinase C in preovulatory follicles from the hen ovary

1991 • 9 citations

Apoptosis-Susceptible Versus-Resistant Granulosa Cells from Hen Ovarian Follicles

1997 • 7 citations