Molecular mechanism of methotrexate action in inflammation

Efficacy of Low-Dose Methotrexate in Rheumatoid Arthritis

1985 • 861 citations

Dietary fish oil and olive oil supplementation in patients with Rheumatoid Arthritis clinical and immunologic effects

1990 • 544 citations

Fish-Oil Fatty Acid Supplementation in Active Rheumatoid Arthritis

1987 • 544 citations

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1983 • 467 citations

Comparison of low‐dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A Controlled Clinical Trial

1985 • 462 citations

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1985 • 460 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.

1990 • 377 citations

The safety and efficacy of the use of methotrexate in long‐term therapy for rheumatoid arthritis

1986 • 362 citations

Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.

1985 • 345 citations

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

1991 • 336 citations

Weekly Pulse Methotrexate in Rheumatoid Arthritis

1985 • 330 citations

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

1985 • 312 citations

Potentiation of Mast Cell Mediator Release by Adenosine

1978 • 273 citations

Methotrexate in the Treatment of Corticosteroid-Dependent Asthma

1988 • 264 citations

The effect of folic acid supplementation on the toxicity of low‐dose methotrexate in patients with rheumatoid arthritis

1990 • 251 citations

Long‐Term Prospective Study of the Use of Methotrexate in the Treatment of Rheumatoid Arthritis

1992 • 248 citations

Long‐term prospective trial of low‐dose methotrexate in rheumatoid arthritis

1988 • 234 citations

Long‐Term Prospective Study of Methotrexate in the Treatment of Rheumatoid Arthritis

1992 • 227 citations

Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis

1987 • 208 citations

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

1986 • 203 citations

Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.

1989 • 203 citations

Inhibition of in vitro vascular endothelial cell proliferation and in vivo neovascularization by low‐dose methotrexate

1989 • 202 citations

A controlled two-centre trial of parenteral methotrexate therapy for refractory rheumatoid arthritis.

1984 • 172 citations

Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In vivo effects of antirheumatic drugs

1991 • 166 citations

Randomised, double-blind, placebo-controlled trial of methotrexate in steroid-dependent asthma

1990 • 147 citations

Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.

1987 • 140 citations

Characterization of a Specific Adenosine Receptor on Human Lymphocytes

1978 • 130 citations

Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory.

1990 • 126 citations

Low‐dose methotrexate compared with auranofin in adult rheumatoid arthritis

1990 • 121 citations

Long-Term Methotrexate Treatment in Corticosteroid-Dependent Asthma

1990 • 115 citations

Inhibition by adenosine of reactive oxygen metabolite production by human polymorphonuclear leucocytes

1985 • 111 citations

Severe flare of rheumatoid arthritis after discontinuation of long-term methotrexate therapy

1987 • 110 citations

Adenosine inhibits and potentiates IgE‐dependent histamine release from human basophils by an A₂‐receptor mediated mechanism

1983 • 105 citations

The Effect of Corticosteroid or Methotrexate Therapy on Lung Lymphocytes and Macrophages in Sarcoidosis

1990 • 104 citations

Low‐dose methotrexate compared with azathioprine in the treatment of rheumatoid arthritis. a twenty‐four—week controlled clinical trial

1987 • 104 citations

The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients

1988 • 102 citations

Advances in Drug Therapy for Inflammatory Bowel Disease

1990 • 97 citations

Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis

1978 • 97 citations

The effects of adenosine agonists on human neutrophil function.

1986 • 95 citations

Antiproliferative effects of methotrexate on peripheral blood mononuclear cells

1989 • 93 citations

PROSPECTIVE LONG TERM FOLLOW-UP OF METHOTREXATE THERAPY IN RHEUMATOID ARTHRITIS: TOXICITY, EFFICACY AND RADIOLOGICAL PROGRESSION

1989 • 85 citations

Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization

1988 • 85 citations

Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis.

1989 • 78 citations

Imidazo[4,5-c]pyridines (3-deazapurines) and their nucleosides as immunosuppressive and antiinflammatory agents

1986 • 76 citations

Adenosine receptors on mouse bone marrow-derived mast cells: functional significance and regulation by aminophylline.

1984 • 75 citations

Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus

1982 • 73 citations

The action of the adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine, on phagocytic function of mouse macrophages and human monocytes

1978 • 73 citations

The effect of methotrexate and hydroxyurea on neutrophil chemotaxis

1980 • 71 citations

Paradoxical effects of adenosine on neutrophil chemotaxis.

1983 • 70 citations

The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats.

1990 • 69 citations

A randomized controlled trial of parenteral methotrexate compared with sodium aurothiomalate (Myochrysine) in the treatment of rheumatoid arthritis.

1988 • 68 citations

The in vitro effects of methotrexate on peripheral blood mononuclear cells: Modulation by methyl donors and spermidine

1990 • 68 citations

Inhibition of Leukotriene B₄ synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate

1990 • 67 citations

Studies on the effect of methotrexate on macrophage function.

1988 • 66 citations

Adenosine regulates the respiratory burst of cytokine-triggered human neutrophils adherent to biologic surfaces.

1989 • 62 citations

Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages

1982 • 62 citations

3-deazaadenosine inhibits leukocyte adhesion and ICAM-1 biosynthesis in tumor necrosis factor-stimulated human endothelial cells.

1990 • 61 citations

Methotrexate in the treatment of steroid-dependent asthma.

1986 • 61 citations

Methotrexate inhibits macrophage activation as well as vascular and cellular inflammatory events in rat adjuvant induced arthritis.

1988 • 60 citations

Methylxanthine bronchodilators potentiate multiple human neutrophil functions.

1987 • 53 citations

Studies on the effect of low dose methotrexate on rat adjuvant arthritis.

1985 • 51 citations

Suppression of B cell function by methotrexate and trimetrexate. Evidence for inhibition of purine biosynthesis as a major mechanism of action.

1988 • 49 citations

Concurrent use of folinic acid and methotrexate in rheumatoid arthritis.

1988 • 47 citations

3-Deazaadenosine. S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes.

1984 • 46 citations

Gold sodium thiomalate compared to low dose methotrexate in the treatment of rheumatoid arthritis--a randomized, double blind 26-week trial.

1989 • 46 citations

Selective adenosine release from human B but not T lymphoid cell line.

1990 • 45 citations

Methotrexate in rheumatoid arthritis: effects on disease activity in a multicenter prospective study.

1991 • 45 citations

Adenosine A2 receptors on human monocytes modulate C2 production.

1984 • 44 citations

Regulation of Macrophage Lysosomal Secretion by Adenosine, Adenosine Phosphate Esters, and Related Structural Analogues of Adenosine

1985 • 42 citations

Inhibition of macrophage phagocytosis by methylation inhibitors. Lack of correlation of protein carboxymethylation and phospholipid methylation with phagocytosis.

1985 • 39 citations

Use of methotrexate in the treatment of steroid-dependent adolescent asthmatics.

1991 • 39 citations

Impaired immunoregulation in systemic lupus erythematosus: defective adenosine-induced suppressor T lymphocyte generation.

1983 • 37 citations

Lymphocyte Membrane Adenosine Receptors Coupled to Adenylate Cyclase Properties and Occurrence in Various Lymphocyte Subclasses

1981 • 35 citations

Effects of adenosine on polymorphonuclear leucocyte function, cyclic 3′:5′‐adenosine monophosphate, and intracellular calcium

1989 • 34 citations

2-Chloroadenosine inhibits complement-induced reactive oxygen metabolite production and recovery of human polymorphonuclear leucocytes attacked by complement

1985 • 33 citations

3-Deazaadenosine-induced disorganization of macrophage microfilaments.

1985 • 32 citations

The influence of methotrexate and thymidine on the human natural killer cell function in vitro.

1983 • 30 citations

Adenosine receptors on rabbit alveolar macrophages: binding characteristics and effects on cellular function.

1987 • 26 citations

Measures of immunologic and inflammatory responses in vitro in rheumatoid patients treated with methotrexate.

1986 • 25 citations

Neutrophil and monocyte chemotaxis in methotrexate-treated psoriasis patients.

1985 • 22 citations

Endogenous and exogenous adenosine inhibit granulocyte aggregation without altering the associated rise in intracellular calcium concentration

1988 • 20 citations

Biochemical perturbations of BW 91Y (3-deazaadenosine) on human neutrophil chemotactic potential and lipid metabolism.

1991 • 19 citations

Occupancy of adenosine receptors on human neutrophils inhibits respiratory burst stimulated by ingestion of complement-coated particles and occupancy of chemoattractant but not Fc receptors

1989 • 18 citations

Endogenous and exogenous adenosine inhibit granulocyte aggregation without altering the associated rise in intracellular calcium concentration

1988 • 17 citations

Regulatory role for the immune complex in modulation of phagocytosis by 3-deazaadenosine.

1984 • 14 citations

3-Deazaadenosine 5′-triphosphate: A novel metabolite of 3-deazaadenosine in mouse leukocytes

1989 • 14 citations

Biochemical perturbations of BW 91Y (3-deazaadenosine) on human neutrophil chemotactic potential and lipid metabolism.

1991 • 13 citations

Adenosine Receptors on Human Lymphocytes

1986 • 13 citations

The effects of some anti-arthritic drugs and cytokines on the shape and function of rodent macrophages.

1991 • 12 citations

Pharmacokinetics of the poly-gamma-glutamyl metabolites of methotrexate in skin and other tissues of rats and hairless mice.

1984 • 12 citations

The effect of low dose chronic intermittent parental methotrexate on delayed type hypersensitivity and acute inflammation in a mouse model.

1986 • 10 citations

3-Deaza-Adenosine Inhibition of Stimulus-Response Coupling in Human Polymorphonuclear Leukocytes

1989 • 8 citations

Effect of Medication on Synovial Fluid Leukocyte Differentials in Patients With Rheumatoid Arthritis

1991 • 8 citations

Suppression of human polymorphonuclear leukocyte phagocytosis by adenosine analogs

1987 • 7 citations

Monocyte and neutrophil chemotaxis in psoriasis. Clinical and experimental studies.

1989 • 7 citations

Effect of anticancer drugs on macrophage-mediated antibody-dependent cytotoxicity and secretion of reactive oxygen intermediates

1988 • 6 citations

Effect of Methotrexate on Phagocytosis and Killing of Staphylococcus Aureus by Human Granulocytes

1980 • 5 citations