Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity

1974 • 1,161 citations

The Enzymatic Synthesis of S-Adenosyl-l-homocysteine from Adenosine and Homocysteine

1959 • 546 citations

Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines

1974 • 298 citations

Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cells

1977 • 267 citations

Adenosine Inhibition of Lymphocyte-Mediated Cytolysis: Possible Role of Cyclic Adenosine Monophosphate

1975 • 265 citations

The Biochemistry of Adenosylmethionine

1978 • 257 citations

S-Adenosyl-L-homocysteine hydrolase: analogues of S-adenosyl-L-homocysteine as potential inhibitors.

1977 • 182 citations

Rapid Stimulation of protein carboxymethylation in leukocytes by a chemotactic peptide

1978 • 170 citations

Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis.

1978 • 169 citations

Pleiotypic Control by Adenosine 3′:5′-Cyclic Monophosphate: A Model for Growth Control in Animal Cells

1973 • 166 citations

Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. I. Resolution and characterization.

1975 • 137 citations

NATURE OF LYMPHOCYTE-TUMOR INTERACTION

1973 • 136 citations

Quantitative studies on phytohaemagglutinin-induced cytotoxicity by human lymphocytes against homologous cells in tissue culture.

1967 • 130 citations

The Role of Cyclic AMP in the Cytolytic Activity of Lymphocytes

1971 • 130 citations

Effects of Cholera Toxin on In Vitro Models of Immediate and Delayed Hypersensitivity. FURTHER EVIDENCE FOR THE ROLE OF CYCLIC ADENOSINE 3′,5′-MONOPHOSPHATE

1973 • 129 citations

Cholinergic Augmentation of Lymphocyte-Mediated Cytotoxicity. A Study of the Cholinergic Receptor of Cytotoxic T Lymphocytes

1974 • 122 citations

Ultrastructure of membrane lesions in immune lysis, osmotic lysis and drug-induced lysis.

1974 • 109 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. II. The use of various target cell markers to study cytolytic events.

1973 • 107 citations

Subcellualr distribution of protein carboxymethylase and its endogenous substrates in the adrenal medulla: possible role in excitation-secretion coupling.

1976 • 103 citations

Analogues of 4-(3,4-dimethoxybenzyl)-2-imidazolidinone as potent inhibitors of rat erythrocyte adenosine cyclic 3',5'-phosphate phosphodiesterase.

1971 • 92 citations

On the Mechanism of T‐Cell Mediated Cytolysis

1973 • 80 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. 3. The role of microfilaments and microtubules.

1973 • 65 citations

Morphological observations on the contact‐induced lysis of target cells

1973 • 63 citations

2-Fluoroadenosine 3':5'-monophosphate. A metabolite of 2-fluoroadenosine in mouse cytotoxic lymphocytes.

1976 • 53 citations

Energy requirements of the binding and lytic steps of T lymphocyte‐mediated cytolysis of leukemic cells in vitro

1975 • 51 citations

Mechanism of Lymphocyte‐Mediated Cytolysis The LMC Cycle and Its Role in Transplantation Immunity

1973 • 50 citations

Inhibition of lymphocyte-mediated cytolysis by adenosine analogs

1978 • 44 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. VI. A reappraisal of the requirement for protein synthesis during T cell-mediated lysis.

1976 • 43 citations

Interaction of lymphocytes with lipid bilayer membranes: a model for lymphocyte-mediated lysis of target cells.

1975 • 42 citations

Protein carboxymethylase and methyl-acceptor proteins in human platelets and erythrocytes

1978 • 35 citations

Inhibition of indolethylamine-N-methyltransferase by analogs of S-adenosylhomocysteine

1975 • 35 citations

A comparison of the effects of metabolic inhibitors upon direct and antibody-dependent lymphocyte mediated cytotoxicity

1975 • 33 citations

Reversible Inhibition of Lymphocyte-Mediated Cytolysis by Dimethyl Sulfoxide (DMSO)

1973 • 29 citations

Suppression of in vivo and in vitro alloimmunity by prostaglandins.

1977 • 16 citations