Polyglutamation of methotrexate. Is methotrexate a prodrug?

Gene amplification in cultured animal cells

1984 • 639 citations

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

1973 • 240 citations

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products.

1980 • 215 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

1982 • 184 citations

Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro.

1982 • 181 citations

Polygammaglutamyl metabolites of methotrexate

1973 • 171 citations

The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.

1976 • 163 citations

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.

1980 • 147 citations

A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates.

1984 • 145 citations

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.

1983 • 105 citations

Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro.

1984 • 100 citations

Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity.

1983 • 84 citations

Stoichiometric inhibition of mammalian dihydrofolate reductase by the γ-glutamyl metabolite of methotrexate, 4-amino-4-deoxy-N10-methylpteroylglutamyl-γ-glutamate

1975 • 81 citations

Tissue-Specific Synthesis of Methotrexate Polyglutamates in the Rat

1975 • 80 citations

Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Purification and properties of folypoly(gamma-glutamate) synthetase.

1980 • 78 citations

Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.

1985 • 70 citations

Methotrexate polyglutamate synthesis by cultured human breast cancer cells.

1980 • 70 citations

Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture.

1984 • 66 citations

Human thymidylate synthetase—III

1979 • 62 citations

Folyl and Antifolyl Polyglutamates

1983 • 62 citations

Accumulation of methotrexate diglutamate in human liver during methotrexate therapy

1977 • 57 citations

Synthesis of methotrexate polyglutamates in cultured human cells.

1978 • 54 citations

The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of (14C)formate incorporation into nucleic acids and protein.

1975 • 52 citations

Folylpoly-γ-glutamate synthesis by bacteria and mammalian cells

1981 • 50 citations

Folylpolyglutamate synthetase from beef liver: assay, stabilization, and characterization

1984 • 25 citations

Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer

1984 • 19 citations