Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Chemistry and biology of pteridines

1956 • 1,263 citations

Chemistry and biology of pteridines 1986

1987 • 335 citations

Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.

1985 • 330 citations

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

1985 • 312 citations

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1981 • 242 citations

Relation of Folic Acid Reductase to Amethopterin Resistance in Cultured Mammalian Cells

1961 • 210 citations

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

1982 • 184 citations

The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.

1976 • 163 citations

Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

1985 • 150 citations

A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates.

1984 • 145 citations

Polyglutamyl Derivatives of Folate as Substrates and Inhibitors of Thymidylate Synthetase

1974 • 145 citations

The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

1986 • 140 citations

The Ability of Purine and Thymine Derivatives and of Glycine to Support the Growth of Mammalian Cells in Culture

1959 • 136 citations

Interactions of pig liver methylenetetrahydrofolate reductase with methylenetetrahydropteroylpolyglutamate substrates and with dihydropteroylpolyglutamate inhibitors

1980 • 115 citations

Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cells

1983 • 113 citations

Human thymidylate synthetase. II. Derivatives of pteroylmono- and -polyglutamates as substrates and inhibitors.

1978 • 110 citations

Pharmacologic Principles of Cancer Treatment

1983 • 109 citations

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.

1983 • 105 citations

The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects

1975 • 84 citations

Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.

1985 • 72 citations

The mechanism of action of methotrexate in cultured L5178Y leukemia cells.

1975 • 66 citations

Human thymidylate synthetase—III

1979 • 62 citations

Prevention of Toxicity of Amethopterin for Sarcoma-180 Cells in Tissue Culture

1957 • 61 citations

Effect of methotrexate on intracellular folate pools in purified myeloid precursor cells from normal human bone marrow.

1987 • 61 citations

Inhibition of pig liver methylenetetrahydrofolate reductase by dihydrofolate: some mechanistic and regulatory implications

1979 • 60 citations

FORMATION OF 4-AMINO-5-CARBOXAMIDOIMIDAZOLE DURING GROWTH OF ESCHERICHIA COLI IN THE PRESENCE OF 4-AMINOPTEROYLGLUTAMIC ACID

1950 • 55 citations

Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells.

1975 • 53 citations

REVERSAL OF AMINOPTERIN AND AMETHOPTERIN TOXICITY BY CITROVORUM FACTOR

1950 • 53 citations

Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine.

1978 • 47 citations

gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.

1985 • 46 citations

Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells.

1982 • 45 citations

Role of methotrexate polyglutamates in methotrexate- and sequential methotrexate-5-fluorouracil-mediated cell kill.

1985 • 35 citations

A rapid assay for 5-amino-4-imidazelecar☐amide ribotide transformylase

1978 • 34 citations

Effect of de novo purine synthesis inhibitors on 5-fluorouracil metabolism and cytotoxicity

1981 • 30 citations

Some Observations on the Reversibility of Methotrexate Toxicity in Normal Proliferating Tissues2

1977 • 28 citations

Aminopterin inhibition in Aerobacter aerogenes: alanine and valine accumulation during the inhibition and their utilization on recovery

1958 • 26 citations

Use of high pressure liquid chromatography to investigate the in vitro reactions of human erythrocytes with guanosine

1973 • 25 citations

Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer

1984 • 19 citations

The effect of leucovorin on the synthesis of methotrexate poly-γ-glutamates in the MCF-7 human breast cancer cell line

1985 • 19 citations

Response of methylenetetrahydrofolate levels to methotrexate in Krebs ascites cells

1983 • 17 citations

Effect of amethopterin and vincaleukoblastinc on urinary 4-amino-5-imidazolecarboxamide

1963 • 9 citations

Effect of various antileukemic compounds on the production of a diazotizable amine (probably 4-amino-5-imidazolecarboxamide) by escherichia coli

1951 • 9 citations

Prevention of Toxicity of Amethopterin for Sarcoma-180 Cells in Tissue Culture

1957 • 8 citations

Insulin effects on methotrexate polyglutamate synthesis and enzyme binding in cultured human breast cancer cells

1985 • 7 citations

Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice

1984 • 3 citations