Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

Chemistry and biology of pteridines

1956 • 1,263 citations

The Biochemistry of Folic Acid and Related Pteridines.

1970 • 1,033 citations

A simple test for inactivation of an enzyme during assay

1965 • 251 citations

Biochemistry of Diseases of Immunodevelopment

1981 • 242 citations

An Improved Purification, Crystallization, and Some Properties of Rabbit Muscle 5'-Adenylic Acid Deaminase

1967 • 203 citations

[8] Kinetic analysis of progress curves

1979 • 170 citations

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.

1980 • 147 citations

Polyglutamyl Derivatives of Folate as Substrates and Inhibitors of Thymidylate Synthetase

1974 • 145 citations

Purification and Properties of 5-Methyltetrahydropteroyltriglutamate-Homocysteine Transmethylase

1970 • 135 citations

Cell killing studies on the mode of action of methotrexate on L-cells in vitro.

1969 • 132 citations

Human thymidylate synthetase. II. Derivatives of pteroylmono- and -polyglutamates as substrates and inhibitors.

1978 • 110 citations

The reliability of Michaelis constants and maximum velocities estimated by using the integrated Michaelis–Menten equation

1973 • 92 citations

Factors determining cell sensitivity to methotrexate: Studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines

1974 • 84 citations

Mechanism of action of methotrexate. IV. Free intracellular methotrexate required to suppress dihydrofolate reduction to tetrahydrofolate by Ehrlich ascites tumor cells in vitro.

1976 • 82 citations

Tetrahydropteroylpolyglutamate derivatives as substrates of two multifunctional proteins with folate-dependent enzyme activities

1980 • 77 citations

Purineless death as a link between growth rate and cytotoxicity by methotrexate.

1972 • 77 citations

Folylpoly-.gamma.-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase

1979 • 75 citations

l(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver

1981 • 62 citations

On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

1981 • 60 citations

On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver

1981 • 59 citations

Formyltetrahydrofolate Synthetas

1973 • 59 citations

AMINOIMIDAZOLECARBOXAMIDE EXCRETION IN VITAMIN-B12 AND FOLIC-ACID DEFICIENCIES

1962 • 58 citations

Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.

1969 • 56 citations

Synthesis and biological evaluation of poly-.gamma.-glutamyl derivatives of methotrexate

1973 • 51 citations

An easy method for the determination of initial rates

1981 • 48 citations

The Turnover of Folate Coenzymes in Murine Lymphoma Cells

1973 • 46 citations

Determination of three different pools of reduced one-carbon-substituted folates

1980 • 46 citations

Purine modulation of methotrexate cytotoxicity in mammalian cell lines.

1982 • 28 citations

Induction of Inosine 5‘-Phosphate Dehydrogenase and Xanthosine 5‘-Phosphate Aminase by Ribosyl-4-amino-5-imidazolecarboxamide in Purine-requiring Mutants of Escherichia coli B

1964 • 17 citations

[66] AMP deaminase from human erythrocytes

1978 • 15 citations

Chromatographic studies of purine metabolism

1958 • 13 citations

Polyglutamyl folate coenzymes and inhibitors of chicken liver glycinamide ribotide transformylase

1982 • 11 citations

Chromatographic studies of purine metabolism. III. Effects of A-methopterin on formate-C14 utilization in mice bearing susceptible and dependent L1210 leukemia

1958 • 11 citations

A critical reexamination of the continous spectrophotometric assay for adenosine deaminase

1982 • 11 citations

Folate catabolism in tumour-bearing rats and rats treated with methotrexate

1981 • 10 citations

The identification of the folate conjugates found in rat liver 48 h after the administration of radioactively labelled folate tracers

1980 • 9 citations

The Determination of the Initial Velocities of Enzyme-Catalysed Reactions from Stopped-Assay Data

1978 • 6 citations

trans-.alpha.,.beta.-Diformamido-.beta.-(5'-phosphoribosylamino)acrylamide: a possible new intermediate in de novo purine biosynthesis

1979 • 4 citations