Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

Intracellular protein topogenesis

1980 • 1,378 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

Synchronised transmembrane insertion and glycosylation of a nascent membrane protein

1977 • 529 citations

Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 414 citations

CONTROLLED PROTEOLYSIS OF NASCENT POLYPEPTIDES IN RAT LIVER CELL FRACTIONS

1970 • 320 citations

Partial resistance of nascent polypeptide chains to proteolytic digestion due to ribosomal shielding

1967 • 290 citations

Chicken ovalbumin contains an internal signal sequence

1979 • 216 citations

A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane.

1980 • 140 citations

Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum.

1980 • 137 citations

Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes.

1979 • 124 citations

POST‐TRANSLATIONAL PROCESSING OF FULL‐LENGTH PRESECRETORY PROTEINS WITH CANINE PANCREATIC SIGNAL PEPTIDASE

1980 • 76 citations

Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones.

1980 • 52 citations

Membrane‐Dependent Cleavage of the Human Placental Lactogen Precursor to Its Native Form in Ascites Cell‐Free Extracts

1977 • 44 citations

Automated sequencing of insoluble peptides using detergent. Bacteriophage fl coat protein.

1977 • 32 citations

A receptor for signal segments of secretory proteins in rough endoplasmic reticulum membranes

1981 • 23 citations