Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes.

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

1973 • 3,279 citations

THE INHIBITION OF CHOLINESTERASE BY PHYSOSTIGMINE AND PROSTIGMINE

1942 • 616 citations

EUKARYOTIC PROTEIN SYNTHESIS

1985 • 538 citations

Different biological properties of the two constituent peptide chains of ricin a toxic protein inhibiting protein synthesis

1973 • 464 citations

Non-Inverted Versus Inverted Plots in Enzyme Kinetics

1959 • 463 citations

Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation

1988 • 447 citations

Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2.

1987 • 339 citations

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

1980 • 323 citations

Effect of diphtheria toxin on protein synthesis: Inactivation of one of the transfer factors

1967 • 232 citations

Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissues.

1985 • 217 citations

Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A.

1984 • 128 citations

Identification by RNA-protein cross-linking of ribosomal proteins located at the interface between the small and the large subunits of mammalian ribosomes.

1982 • 88 citations

Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells.

1980 • 85 citations

The Binding of Tritiated Elongation Factors 1 and 2 to Ribosomes from Krebs II Mouse Ascites Tumor Cells

1975 • 57 citations

Endogenous ADP-ribosylation of elongation factor 2 in polyoma virus-transformed baby hamster kidney cells.

1989 • 57 citations

Presence in many mammalian tissues of an identical major cytosolic substrate (M_r 100000) for calmodulin‐dependent protein kinase

1983 • 54 citations

The mechanism of the protein‐synthesis elongation cycle in eukaryotes

1986 • 54 citations

The histidine residue of codon 715 is essential for function of elongation factor 2

1989 • 38 citations

Reduced ribosomal binding of eukaryotic elongation factor 2 following ADP-ribosylation. Difference in binding selectivity between polyribosomes and reconstituted monoribosomes

1985 • 38 citations

Heterogeneity of native rat liver elongation factor 2

1989 • 37 citations

Interaction of guanosine nucleotides with elongation factor 2. I. Equilibrium dialysis studies

1975 • 37 citations

Characterization of the ribosomal properties required for formation of a GTPase active complex with the eukaryotic elongation factor 2

1989 • 33 citations

Eukaryotic elongation factor 2 loses its non‐specific affinity for RNA and leaves polyribosomes as a result of ADP‐ribosylation

1984 • 32 citations

Affinity labelling of the eukaryotic elongation factor EF-2 with the guanosine nucleotide analogue 5′-p-fluorosulfonylbenzoylguanosine

1984 • 30 citations

The ribosomal binding site for eukaryotic elongation factor EF-2 contains 5 S ribosomal RNA

1987 • 29 citations

Nucleotide‐mediated interactions of eukaryotic elongation factor EF‐2 with ribosomes

1984 • 28 citations

Quantification of the different ribosomal phases during the translational elongation cycle in rabbit reticulocyte lysates

1984 • 27 citations

Interactions of Elongation Factor 2 (EF‐2) with Guanine Nucleotides and Ribosomes

1980 • 25 citations

Structural and functional studies of the interaction of the eukaryotic elongation factor EF‐2 with GTP and ribosomes

1988 • 25 citations

Interaction of guanosine nucleotides with elongation factor 2. II. Effect of ribosomes and magnesium ions on guanosine diphosphate and guanosine triphosphate binding to the enzyme

1975 • 24 citations

Identification of Nsp100 as elongation factor 2 (EF‐2)

1989 • 20 citations

Nucleotide binding to elongation factor 2 inactivated by diphtheria toxin

1986 • 18 citations

[42] Measurement of translational kinetic parameters

1988 • 15 citations

Spectrophotometric assay of GTPase and ATPase activities related to protein synthesis

1980 • 9 citations

Ions that fit into place

1988 • 5 citations