Highly frequent single amino acid substitution in mammalian elongation factor 2 (EF-2) results in expression of resistance to EF-2-ADP-ribosylating toxins.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

1978 • 744 citations

Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP

1986 • 717 citations

NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,.

1975 • 619 citations

The role of guanosine 5′-triphosphate in polypeptide chain elongation

1978 • 559 citations

Diphtheria Toxin-dependent Adenosine Diphosphate Ribosylation of Aminoacyl Transferase II and Inhibition of Protein Synthesis

1968 • 536 citations

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

1980 • 323 citations

Reconstitution of Diphtheria Toxin from Two Nontoxic Cross-Reacting Mutant Proteins

1972 • 177 citations

Soluble Factors Required for Eukaryotic Protein Synthesis

1976 • 172 citations

STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN

1969 • 170 citations

Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.

1983 • 153 citations

Amino acid sequence of mammalian elongation factor 2 deduced from the cDNA sequence: homology with GTP-binding proteins.

1986 • 141 citations

Parameters governing the transfer of the genes for thymidine kinase and dihydrofolate reductase into mouse cells using metaphase chromosomes or DNA

1980 • 139 citations

Archaebacterial elongation factor is ADP-ribosylated by diphtheria toxin

1980 • 125 citations

Elongation Factor 2

1974 • 108 citations

Selection and characterization of cells resistant to diphtheria toxin and pseudomonas exotoxin A: presumptive translational mutants

1977 • 101 citations

Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells.

1980 • 85 citations

Primary structure at the site in beef and wheat elongation factor 2 of ADP‐ribosylation by diphtheria toxin

1979 • 73 citations

Aminoacyltransferase II from Rat Liver

1971 • 67 citations

Characterization of the diphtheria toxin-resistance system in Chinese hamster ovary cells

1979 • 66 citations

In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin.

1984 • 63 citations

Occurrence of diphthamide in archaebacteria

1983 • 60 citations

Purification and properties of rabbit reticulocyte protein synthesis elongation factor 2.

1975 • 57 citations

Studies on Transferase II Using Diphtheria Toxin

1969 • 50 citations

Diphtheria-toxin-resistant mutants of CHO cells affected in protein synthesis: A novel phenotype

1978 • 48 citations

Biochemical and genetic characterization of three hamster cell mutants resistant to diphtheria toxin

1979 • 41 citations

Reduced ribosomal binding of eukaryotic elongation factor 2 following ADP-ribosylation. Difference in binding selectivity between polyribosomes and reconstituted monoribosomes

1985 • 38 citations

Characterization of diphtheria-toxin-resistant mutants lacking receptor function or containing nonribosylatable elongation factor 2

1985 • 34 citations

Formation of a complex involving ADP‐ribosylated human translocation factor, guanosine nucleotide and ribosomes

1972 • 33 citations

Studies on Polypeptide Elongation Factor 2 from Pig Liver

1974 • 32 citations

Diphtheria toxin resistance in chinese hamster cells: Genetic and biochemical characteristics of the mutants affected in protein synthesis

1980 • 28 citations

[38] Diphthamide in elongation factor 2: ADP-ribosylation, purification, and properties

1984 • 22 citations

Chromosomal assignment of the gene for human elongation factor 2.

1984 • 20 citations

Interactions of adenosine diphosphate-ribosylated elongation factor 2 with ribosomes.

1976 • 20 citations

Purification and characterization of homogeneous protein synthesis elongation factor 2 from hen oviduct

1977 • 4 citations