Gene expression of insulin signal-transduction pathway intermediates is lower in rats fed a beef tallow diet than in rats fed a safflower oil diet

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Banting lecture 1988. Role of insulin resistance in human disease

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The insulin signaling system.

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EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

The nucleotide sequence of the rat cytoplasmic β–actin gene

1983 • 1,059 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain

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Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974.

1980 • 865 citations

Insulin Action and the Insulin Signaling Network*

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Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

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Cancer Research: Some Forward Steps

1965 • 733 citations

Epidemiological Studies in the Upernavik District, Greenland

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Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

PLASMA LIPIDS AND LIPOPROTEINS IN GREENLANDIC WEST COAST ESKIMOS

1972 • 578 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

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Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

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Functionally distinct insulin receptors generated by tissue-specific alternative splicing.

1990 • 356 citations

Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.

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Energy intake and other determinants of relative weight

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Decreased insulin binding to adipocytes and circulating monocytes from obese subjects.

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Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

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Alternative splicing of human insulin receptor messenger RNA

1989 • 312 citations

Tissue-Specific Expression of Two Alternatively Spliced Insulin Receptor mRNAs in Man

1989 • 308 citations

Less Body Fat Accumulation in Rats Fed a Safflower Oil Diet Than in Rats Fed a Beef Tallow Diet

1990 • 286 citations

Insulin Receptor Deficiency in Genetic and Acquired Obesity

1975 • 262 citations

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.

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Dietary supplementation of omega-3 polyunsaturated fatty acids improves insulin sensitivity in non-insulin-dependent diabetes.

1987 • 180 citations

Diet-induced thermogenesis is lower in rats fed a lard diet than in those fed a high oleic acid safflower oil diet, a safflower oil diet or a linseed oil diet.

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Insulin binding and effects in isolated soleus muscle of lean and obese mice.

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The Rat Insulin Receptor: Primary Structure and Conservation of Tissue-Specific Alternative Messenger RNA Splicing

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Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

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Insulin-Receptor Autophosphorylation and Endogenous Substrate Phosphorylation in Human Adipocytes From Control, Obese, and NIDDM Subjects

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A method for preparing intact animals for carcass analyses.

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The relationship of dietary fat to plasma lipid levels as studied by factor analysis of adipose tissue fatty acid composition in a free-living population of middle-aged American men

1986 • 76 citations

Sympathetic activity is lower in rats fed a beef tallow diet than in rats fed a safflower oil diet

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Alteration of Insulin-Receptor Kinase Activity by High-Fat Feeding

1988 • 58 citations

Effects of Endurance Training of Gene Expression on Insulin Signal Transduction Pathway

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Effect of diet change on insulin action: difference between muscles and adipocytes

1986 • 49 citations

Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey.

1994 • 48 citations

Effect of High-Fat Diet on Gene Expression of GLUT4 and Insulin Receptor in Soleus Muscle

1994 • 47 citations

Early alteration of insulin stimulation of PI 3-kinase in muscle and adipocyte from gold thioglucose obese mice

1995 • 41 citations

Effects of the Type of Dietary Fatty Acid on the Insulin Receptor Function in Rat Epididymal Fat Cells

1986 • 39 citations

Compensatory alterations for insulin signal transduction and glucose transport in insulin-resistant diabetes

1995 • 36 citations

Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects

1990 • 29 citations

Insulin receptor tyrosine kinase activity is unaltered in ob/ob and db/db mouse skeletal muscle membranes

1987 • 26 citations

Alteration of insulin-receptor kinase activity by high-fat feeding

1988 • 24 citations

Dietary Influence on the Insulin Function in the Epididymal Fat Cell of the Wistar Rat

1988 • 19 citations

The Antihyperglycemic Agent Englitazone Prevents the Defect in Glucose Transport in Rats Fed a High-Fat Diet

1996 • 19 citations

The antihyperglycemic agent englitazone prevents the defect in glucose transport in rats fed a high-fat diet

1996 • 9 citations