Phosphatidylserine recognition by phagocytes: a view to a kill

Integrin Signaling

1999 • 3,705 citations

A blast from the past: clearance of apoptotic cells regulates immune responses

2002 • 1,558 citations

Identification of a factor that links apoptotic cells to phagocytes

2002 • 1,323 citations

Phagocytosis and clearance of apoptotic cells is mediated by MER

2001 • 1,153 citations

Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3

2005 • 1,052 citations

Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

2004 • 972 citations

Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat

2000 • 844 citations

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

1992 • 818 citations

Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family

2001 • 673 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Phagocytosis

2005 • 635 citations

Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase

2002 • 627 citations

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

2002 • 604 citations

Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex

2002 • 569 citations

Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells

2001 • 541 citations

Apoptotic cell removal

2001 • 472 citations

Crk family adaptors–signalling complex formation and biological roles

2001 • 460 citations

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

2001 • 427 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells

2003 • 396 citations

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

2001 • 394 citations

Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells

2002 • 382 citations

αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

2000 • 375 citations

Rack1, a Receptor for Activated Protein Kinase C, Interacts with Integrin β Subunit

1998 • 351 citations

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

2002 • 327 citations

The phosphatidylserine receptor: a crucial molecular switch?

2001 • 325 citations

Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

2005 • 310 citations

A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.

1999 • 310 citations

Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking αvβ5 Integrin

2004 • 297 citations

Lactadherin promotes VEGF-dependent neovascularization

2005 • 291 citations

Transcriptional Suppression of Interleukin-12 Gene Expression following Phagocytosis of Apoptotic Cells

2004 • 267 citations

A Novel Receptor Tyrosine Kinase, Mer, Inhibits TNF-α Production and Lipopolysaccharide-Induced Endotoxic Shock

1999 • 266 citations

A role for Mer tyrosine kinase in αvβ5 integrin-mediated phagocytosis of apoptotic cells

2005 • 263 citations

Masking of Phosphatidylserine Inhibits Apoptotic Cell Engulfment and Induces Autoantibody Production in Mice

2004 • 260 citations

PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.

1998 • 246 citations

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

2005 • 244 citations

THE ENGULFMENT PROCESS OF PROGRAMMED CELL DEATH INCAENORHABDITIS ELEGANS

2004 • 242 citations

An RCS-Like Retinal Dystrophy Phenotype inMerKnockout Mice

2003 • 238 citations

Promotion of the Uptake of PS Liposomes and Apoptotic Cells by a Product of Growth Arrest-Specific Gene, gas6

2000 • 224 citations

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

2005 • 219 citations

The opsonin MFG-E8 is a ligand for the αvβ5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells

2003 • 212 citations

Functional Analyses of Two Cellular Binding Domains of Bovine Lactadherin

2000 • 203 citations

Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation

1997 • 197 citations

Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors

2003 • 194 citations

Innate Immune Discrimination of Apoptotic Cells: Repression of Proinflammatory Macrophage Transcription Is Coupled Directly to Specific Recognition

2004 • 189 citations

Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.

1996 • 188 citations

Monoclonal Antiphosphatidylserine Antibody Inhibits Intercellular Fusion of the Choriocarcinoma Line, JAR1

1995 • 171 citations

Cell Surface-expressed Phosphatidylserine and Annexin A5 Open a Novel Portal of Cell Entry

2004 • 160 citations

Apoptotic mimicry by an obligate intracellular parasite downregulates macrophage microbicidal activity

2001 • 155 citations

“Recruitment Signals” from Apoptotic Cells

2003 • 150 citations

Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages

1999 • 149 citations

Expression of Developmental Endothelial Locus-1 in a Subset of Macrophages for Engulfment of Apoptotic Cells

2004 • 142 citations

Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells

2005 • 142 citations

Macrophage and Retinal Pigment Epithelium Phagocytosis

1999 • 142 citations

Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells

2005 • 128 citations

Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor

2004 • 118 citations

PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis

2004 • 116 citations

Inhibition of vascular endothelial growth factor receptor 2–mediated endothelial cell activation by Axl tyrosine kinase receptor

2004 • 110 citations

Immunologic Stimulation of Mast Cells Leads to the Reversible Exposure of Phosphatidylserine in the Absence of Apoptosis

2000 • 101 citations

An SH2 Domain-dependent, Phosphotyrosine-independent Interaction between Vav1 and the Mer Receptor Tyrosine Kinase

2003 • 99 citations

Biological Effects of c-Mer Receptor Tyrosine Kinase in Hematopoietic Cells Depend on the Grb2 Binding Site in the Receptor and Activation of NF-κB

1999 • 97 citations

Apoptosis: giving phosphatidylserine recognition an assist – with a twist

2003 • 92 citations

Thrombospondin 2 Functions as an Endogenous Regulator of Angiogenesis and Inflammation in Rheumatoid Arthritis

2004 • 90 citations

The Embryonic Angiogenic Factor Del1 Accelerates Tumor Growth by Enhancing Vascular Formation

2002 • 87 citations

Opsonization of Apoptotic Cells: Implications for Uptake and Autoimmunity

2000 • 87 citations

The receptor tyrosine kinase MerTK activates phospholipase C γ2 during recognition of apoptotic thymocytes by murine macrophages

2004 • 79 citations

Identification of the Major Autophosphorylation Sites of Nyk/Mer, an NCAM-related Receptor Tyrosine Kinase

1996 • 75 citations

Gas6 Induces Growth, β-Catenin Stabilization, and T-Cell Factor Transcriptional Activation in Contact-Inhibited C57 Mammary Cells

2001 • 71 citations

Signaling between Focal Adhesion Kinase and Trio

2003 • 63 citations

The Plasma Membrane Is the Site of Selective Phosphatidylserine Oxidation During Apoptosis: Role of Cytochromec

2004 • 41 citations

Cytochrome c release is required for phosphatidylserine peroxidation during fas‐triggered apoptosis in lung epithelial A549 cells

2004 • 39 citations

Engulfment: Ingestion and Migration with Rac, Rho and TRIO

2005 • 35 citations

The effect of phospholipids on the formation of immune complexes between autoantibodies and β2-glycoprotein I or prothrombin

2004 • 33 citations

Role of αvβ5 Integrin in Regulating Phagocytosis by the Retinal Pigment Epithelium

2003 • 27 citations

The Phagocytosis of OS is Mediated by the PI3-Kinase Linked Tyrosine Kinase Receptor, Mer, and is Stimulated by Gas6

2003 • 24 citations

Aberrant Expression of the NF-κB and IκB Proteins in B Cells from Viable Motheaten Mice

1999 • 7 citations