The effect of phospholipids on the formation of immune complexes between autoantibodies and β2-glycoprotein I or prothrombin

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1990 • 1,618 citations

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

1990 • 1,294 citations

Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH.

1995 • 1,179 citations

Criteria for the Diagnosis of Lupus Anticoagulants: An Update

1995 • 954 citations

Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature

2003 • 952 citations

Lupus Anticoagulant IgG's (LA) Are Not Directed to Phospholipids only, but to a Complex of Lipid-Bound Human Prothrombin

1991 • 583 citations

Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

1994 • 535 citations

The Mode of Action of Vitamin K

1974 • 527 citations

Lipid translocation across the plasma membrane of mammalian cells

1999 • 437 citations

Anti–β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome

2003 • 422 citations

The adsorption of prothrombin to phosphatidylserine multilayers quantitated by ellipsometry.

1983 • 383 citations

beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway

1985 • 364 citations

"Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding.

1995 • 337 citations

Adhesion mechanism of human beta 2-glycoprotein I to phospholipids based on its crystal structure

1999 • 333 citations

Complete amino acid sequence of human plasma beta 2-glycoprotein I.

1984 • 326 citations

Antiphospholipid antibodies and thrombosis

1999 • 313 citations

Prothrombinase activity of human platelets is inhibited by β2-glycoprotein-I

1986 • 308 citations

Crystal structure of human β2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome

1999 • 301 citations

Lipid–protein interactions in blood coagulation

1998 • 288 citations

The fifth domain of beta 2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies.

1994 • 275 citations

β2-glycoprotein-I (apolipoprotein H) interactions with phospholipid vesicles

1984 • 234 citations

High Affinity Binding of β2-Glycoprotein I to Human Endothelial Cells Is Mediated by Annexin II

2000 • 220 citations

Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies

1990 • 216 citations

Development of an ELISA for Autoantibodies to Prothrombin Showing their Prevalence in Patients with Lupus Anticoagulants

1995 • 215 citations

A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome

1983 • 214 citations

Anti-phospholipid autoantibodies bind to apoptotic, but not viable, thymocytes in a beta 2-glycoprotein I-dependent manner.

1996 • 210 citations

Role of Divalency in the High-Affinity Binding of Anticardiolipin Antibody−β₂-Glycoprotein I Complexes to Lipid Membranes

1996 • 201 citations

Measurement of anti-phospholipid antibodies by ELISA using β2-glycoprotein I as an antigen

1991 • 191 citations

Complete nucleotide and deduced amino acid sequence of human β2-glycoprotein I

1991 • 187 citations

Anticoagulant Activity of β2-Glycoprotein I Is Potentiated by a Distinct Subgroup of Anticardiolipin Antibodies

1992 • 183 citations

Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant

1989 • 178 citations

Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity.

1993 • 177 citations

Thrombogenicity of β2-glycoprotein I–dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster

2002 • 174 citations

Different Anticoagulant and Immunological Properties of Anti-Prothrombin Antibodies in Patients with Antiphospholipid Antibodies

1997 • 169 citations

Autoantibodies to Phospholipid-binding Plasma Proteins in Patients with Thrombosis and Phospholipid-reactive Antibodies

1996 • 163 citations

Site-directed mutagenesis of recombinant human beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity.

1996 • 162 citations

Activation of human post heparin lipoprotein lipase by apolipoprotein H (β2-glycoprotein I)

1980 • 156 citations

�ber ein bisher unbekanntes niedermolekulares ?2-Glubulin des Humanserums

1961 • 152 citations

Immune Clearance of Phosphatidylserine-expressing Cells by Phagocytes

1997 • 148 citations

Amino acid sequence and location of the disulfide bonds in bovine .beta.2 glycoprotein I: the presence of five Sushi domains

1991 • 138 citations

Prothrombin as Co-Factor of the Circulating Anticoagulant in Systemic Lupus Erythematosus?

1959 • 130 citations

Functional and binding studies of the roles of prothrombin and beta 2- glycoprotein I in the expression of lupus anticoagulant activity

1994 • 130 citations

Anti-beta2-glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the beta2GPI binding to phospholipids.

1997 • 129 citations

Antiphospholipid Syndrome: Diagnostic Aspects of Lupus Anticoagulants

2001 • 127 citations

Complete amino acid sequence of human plasma β_2-glycoprotein I

1984 • 122 citations

Differential Effects of Anti–β2-Glycoprotein I and Antiprothrombin Antibodies on the Anticoagulant Activity of Activated Protein C

1998 • 119 citations

β2-Glycoprotein I Deficiency and the Risk of Thrombosis

1992 • 114 citations

Membrane-dependent reactions in blood coagulation: role of the vitamin K-dependent enzyme complexes

1994 • 110 citations

Contributions of Gla and EGF-Like Domains to the Function of Vitamin K-Dependent Coagulation Factors

1999 • 108 citations

Binding of β2-glycoprotein I to platelets: Effect of adenylate cyclase activity

1980 • 107 citations

Comparison of Naturally Occurring Vitamin K-Dependent Proteins: Correlation of Amino Acid Sequences and Membrane Binding Properties Suggests a Membrane Contact Site

1997 • 104 citations

Beta-2-glycoprotein I Dependent Lupus Anticoagulants Form Stable Bivalent Antibody Beta-2-Glycoprotein I Complexes on Phospholipid Surfaces

1998 • 101 citations

Solution Structure of Human and Bovine β2-Glycoprotein I Revealed by Small-angle X-ray Scattering

2002 • 98 citations

Anti-beta 2-glycoprotein I autoantibodies from patients with the "antiphospholipid" syndrome bind to beta 2-glycoprotein I with low affinity: dimerization of beta 2-glycoprotein I induces a significant increase in anti-beta 2-glycoprotein I antibody affinity.

1998 • 90 citations

Impaired Thrombin Generation in β2-Glycoprotein I Null Mice

2001 • 88 citations

A new model to describe extrinsic protein binding to phospholipid membranes of varying composition: application to human coagulation proteins

1989 • 87 citations

Mechanism and effects of the binding of lupus anticoagulant IgG and prothrombin to surface phospholipid

1996 • 86 citations

Molecular definition of human β₂-glycoprotein (α₂-GPI) by cDNA cloning and inter-species differences of β₂-GPI in alternation of anticardiolipin binding

1991 • 86 citations

Identification of Structural Mutations in the Fifth Domain of Apolipoprotein H ( 2-Glycoprotein I) Which Affect Phospholipid Binding

1997 • 86 citations

Interaction of β2-Glycoprotein-I with Human Blood Platelets: Influence Upon the ADP-Induced Aggregation

1985 • 85 citations

Complexes of anti‐prothrombin antibodies and prothrombin cause lupus anticoagulant activity by competing with the binding of clotting factors for catalytic phospholipid surfaces

2001 • 80 citations

Antibody-Mediated Disruption of the Annexin-V Antithrombotic Shield: A New Mechanism for Thrombosis in the Antiphospholipid Syndrome

1999 • 78 citations

Anti-β2-Glycoprotein I Autoantibodies from Patients with the “Antiphospholipid” Syndrome Bind to β2-Glycoprotein I with Low Affinity: Dimerization of β2-Glycoprotein I Induces a Significant Increase in Anti-β2-Glycoprotein I Antibody Affinity

1998 • 78 citations

Dimers of β2-Glycoprotein I Mimic thein Vitro Effects of β2-Glycoprotein I-Anti-β2-glycoprotein I Antibody Complexes

2001 • 76 citations

Mechanism and effects of the binding of lupus anticoagulant IgG and prothrombin to surface phospholipid

1996 • 76 citations

Nucleotide sequence and expression of the human gene encoding apolipoprotein H (β2-glycoprotein I)

1991 • 75 citations

Studies on the possible function of β2-glycoprotein-I: Influence in the triglyceride metabolism in the rat

1982 • 74 citations

Antiphospholipid Antibodies Differ in aPL Cofactor Requirement

1992 • 74 citations

Conformationally altered β2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies

1999 • 72 citations

Induction of Anti-Phospholipid Autoantibodies by β2-glycoprotein I Bound to Apoptotic Thymocytes

1998 • 71 citations

Characterization of binding of human β2-glycoprotein I to cardiolipin

1995 • 68 citations

Changes in β2-Glycoprotein I Antigenicity Induced by Phospholipid Binding

1993 • 67 citations

Competition of Annexin V and Anticardiolipin Antibodies for Binding to Phosphatidylserine Containing Membranes

2000 • 61 citations

A hydrophobic sequence at position 313–316 (Leu‐Ala‐Phe‐Trp) in the fifth domain of apolipoprotein H (β₂‐glycoprotein I) is crucial for cardiolipin binding

2000 • 58 citations

The adsorption of prothrombin to phospholipid monolayers quantitated by ellipsometry.

1984 • 56 citations

Mechanism of the Interaction of β₂-Glycoprotein I with Negatively Charged Phospholipid Membranes

2001 • 51 citations

Kinetic and mechanistic analysis of prothrombin-membrane binding by stopped-flow light scattering

1982 • 49 citations

A Binding Site Expressed on the Surface of Activated Human Platelets Is Shared by Factor X and Prothrombin

1996 • 49 citations

Binding of β2-glycoprotein-I to Intralipid: Determination of the dissociation constant

1979 • 49 citations

Interactions and molecular structure of cardiolipin and β2-glycoprotein 1 (β2-GP1)

1995 • 46 citations

Role of the N- and C-Terminal Domains of Bovine β2-Glycoprotein I in Its Interaction with Cardiolipin1

1995 • 46 citations

Phospholipid-Specific Conformational Changes in Human Prothrombin upon Binding to Procoagulant Acidic Lipid Membranes

1994 • 46 citations

Acquired activated protein C resistance is associated with the co‐existence of anti‐prothrombin antibodies and lupus anticoagulant activity in patients with systemic lupus erythematosus

2002 • 45 citations

Differences in the Interactions of Lupus Anticoagulant IgG with Human Prothrombin and Bovine Prothrombin

1995 • 44 citations

Identification of the Phospholipid-binding Site of Human β2-Glycoprotein I Domain V by Heteronuclear Magnetic Resonance

2000 • 44 citations

Prothrombin Binds to the Surface of Apoptotic, But Not Viable, Cells and Serves as a Target of Lupus Anticoagulant Autoantibodies

2003 • 44 citations

Characterization of beta2-glycoprotein I binding to phospholipid membranes.

1998 • 38 citations

Lupus Antibody Bivalency Is Required to Enhance Prothrombin Binding to Phospholipid

2001 • 34 citations

αIIbβ3 and Its Antagonism at the New Millennium

2001 • 33 citations

Dynamic Features of Prothrombin Interaction with Phospholipid Vesicles of Different Size and Composition: Implications for Protein−Membrane Contact

1996 • 32 citations

Lupus Anticoagulants Form Immune Complexes With Prothrombin and Phospholipid That Can Augment Thrombin Production in Flow

1999 • 29 citations

Further family studies on the genetic control of ?2-glycoprotein I concentration in human serum

1969 • 29 citations

Interaction of prothrombin with factor Va-phospholipid complexes

1984 • 27 citations

Characterization of isoelectric subspecies of asialo-β2-glycoprotein I

1989 • 24 citations

Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids

1999 • 22 citations

The catalytic role of anionic phospholipids in the activation of protein C by factor Xa and expression of its anticoagulant function in human plasma

1991 • 20 citations

Phosphatidylserine-Containing Membranes Alter the Thermal Stability of Prothrombin's Catalytic Domain: A Differential Scanning Calorimetric Study

1994 • 19 citations

Time-resolved fluorescence study of a calcium-induced conformational change in prothrombin fragment 1

1996 • 18 citations

Kinetics of Prothrombin-Mediated Binding of Lupus Anticoagulant Antibodies to Phosphatidylserine-Containing Phospholipid Membranes: An Ellipsometric Study

2002 • 17 citations

Polymorphisms β2-glycoprotein I: phospholipid binding and multimeric structure

2002 • 17 citations

Addition of deoxycholate in electroimmunoassay and crossed immunofocusing for quantification of β2-glycoprotein I and its subfractions

1982 • 17 citations

Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids

1999 • 13 citations

A Stable, Multi-Subunit Complex of β2Glycoprotein I

1998 • 9 citations