Lipoxygenases and hydroperoxy/hydroxy-eicosatetraenoic acid formation

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes

1979 • 812 citations

Diglyceride lipase: a pathway for arachidonate release from human platelets.

1979 • 696 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

Arachidonate lipoxygenase in blood platelets

1975 • 613 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, and Other Derivatives of Carbon‐20 Unsaturated Fatty Acids

1982 • 580 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Caffeic acid is a selective inhibitor for leukotriene biosynthesis

1984 • 349 citations

Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid.

1980 • 330 citations

Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.

1986 • 311 citations

Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro

1982 • 308 citations

Selective inhibition of platelet lipoxygenase by baicalein

1982 • 245 citations

Autoxidation of polyunsaturated lipids. Factors controlling the stereochemistry of product hydroperoxides

1980 • 240 citations

Peroxidase-dependent deactivation of prostacyclin synthetase

1979 • 231 citations

Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid

1986 • 229 citations

Leukotrienes and Other Lipoxygenase Products in the Pathogenesis and Therapy of Psoriasis and Other Dermatoses

1983 • 227 citations

The Molecular basis of neuropathology

1981 • 217 citations

Prostaglandins and other arachidonic acid metabolites in the kidney

1986 • 206 citations

The platelets physiology and pharmacology

1986 • 203 citations

Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.

1982 • 202 citations

Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis

1983 • 199 citations

Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid.

1982 • 196 citations

15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase.

1980 • 195 citations

Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets.

1977 • 191 citations

Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids.

1986 • 191 citations

Formation of novel hydroxylated eicosatetraenoic acids in preparations of human polymorphonuclear leukocytes

1981 • 165 citations

Prostacyclin and arterial wall biology.

1982 • 164 citations

Lipoxin A. Stereochemistry and biosynthesis.

1986 • 162 citations

Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry.

1986 • 160 citations

Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid

1982 • 155 citations

Comparative effect of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cell migration

1982 • 149 citations

Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.

1982 • 147 citations

Altered lipoxygenase metabolism and decreased glutathione peroxidase activity in platelets from selenium-deficient rats

1980 • 143 citations

Synthesis of hydroxy fatty acids from 4, 7, 10, 13, 16, 19-[1-14C] docosahexaenoic acid by human platelets.

1983 • 142 citations

12S,20-dihydroxyicosatetraenoic acid: a new icosanoid synthesized by neutrophils from 12S-hydroxyicosatetraenoic acid produced by thrombin- or collagen-stimulated platelets.

1984 • 139 citations

Biochemistry of Arachidonic Acid Metabolism

1985 • 138 citations

The regulation of human eosinophil function by endogenous mono-hydroxy-eicosatetraenoic acids (HETEs).

1980 • 138 citations

Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects.

1986 • 135 citations

Role of glutathione peroxidase and hexose monophosphate shunt in the platelet lipoxygenase pathway.

1982 • 131 citations

Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxidase

1977 • 130 citations

Lipoxygenase Pathway in Islet Endocrine Cells. OXIDATIVE METABOLISM OF ARACHIDONIC ACID PROMOTES INSULIN RELEASE

1983 • 125 citations

Release of leukotriene C₄ from human polymorphonuclear leucocytes as determined by radioimmunoassay

1982 • 119 citations

Analysis of leukotrienes by high-pressure liquid chromatography

1981 • 119 citations

Biosynthesis and metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid by human umbilical vein endothelial cells.

1984 • 117 citations

The production of the arachidonate metabolite HETE in vascular tissue

1979 • 115 citations

Novel leukotrienes: Products formed by initial oxygenation of arachidonic acid at C-15

1981 • 112 citations

Identification of 15–hydroxy‐5,8,11,13–eicosatetraenoic acid (15–HETE) as a major metabolite of arachidonic acid in human lung

1980 • 112 citations

New role for 15-hydroxyeicosatetraenoic acid. Activator of leukotriene biosynthesis in PT-18 mast/basophil cells.

1982 • 109 citations

Regulation of T-lymphocyte mitogenesis by the leukocyte product 15-hydroxy-eicosatetraenoic acid (15-HETE)

1982 • 109 citations

Metabolism of 8,11,14-eicosatrienoic acid in human platelets

1976 • 105 citations

Isolation of a new lipoxygenase metabolite of arachidonic acid, 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid from human platelets

1979 • 100 citations

The identification of trihydroxyeicosatrienoic acids as products from the incubation of arachidonic acid with washed blood platelets

1978 • 99 citations

15-Hydroxy-5,8,11,13-eicosatetraenoic acid inhibits human vascular cyclooxygenase. Potential role in diabetic vascular disease.

1986 • 98 citations

Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.

1986 • 97 citations

Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis.

1981 • 96 citations

Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes.

1983 • 93 citations

Vitamin E modulates the lipoxygenation of arachidonic acid in leukocytes

1980 • 93 citations

Interference of some flavonoids and non-steroidal anti-inflammatory drugs with oxidative metabolism of arachidonic acid by human platelets and neutrophils

1985 • 92 citations

Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action.

1987 • 92 citations

Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids

1982 • 89 citations

Purification of a mammalian 5-lipoxygenase from rat basophilic leukemia cells

1985 • 89 citations

Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells.

1983 • 85 citations

Effects of reduced glutathione on the 12-lipoxygenase pathways in rat platelets

1982 • 85 citations

Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate.

1984 • 83 citations

Stimulation of eicosapentaenoic acid metabolism in washed human platelets by 12-hydroperoxyeicosatetraenoic acid.

1983 • 82 citations

Production of 12-Hydroxyeicosatetraenoic Acid and Vitamin E Status in Platelets from Type I Human Diabetic Subjects

1985 • 80 citations

The role of phospholipase C in platelet responses

1983 • 79 citations

Fatty acid structural requirements for leukotriene biosynthesis

1980 • 78 citations

Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets

1979 • 72 citations

Inhibition of platelet and neutrophil phospholipase A2 by hydroxyeicosatetraenoic acids (HETEs) A novel pharmacological mechanism for regulating free fatty acid release

1985 • 72 citations

Transformation of arachidonic acid into monohydroxy‐eicosatetraenoic acids by mouse peritoneal macrophages

1981 • 71 citations

Formation of monohydroxyeicosatetraenoic acids from arachidonic acid by cultured rabbit aortic smooth muscle cells

1983 • 70 citations

Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases

1985 • 64 citations

The metabolism of leukotrienes in blood plasma studied by high-performance liquid chromatography

1985 • 62 citations

Generation of the arachidonic acid metabolite 8-HETE by extracts of mouse skin treated with phorbol ester in vivo; identification by ¹H-n.m.r. and GC-MS spectroscopy

1986 • 62 citations

Enhancement of anaphylactic mediator release from guinea-pig perfused lungs by fatty acid hydroperoxides

1978 • 61 citations

Calcium stimulation of the 5-lipoxygenase from RBL-1 cells

1982 • 61 citations

Inactivation of vascular prostacyclin synthetase by platelet lipoxygenase products

1980 • 60 citations

On the mechanism of biosynthesis of leukotrienes and related compounds

1982 • 60 citations

The identification of an epoxy-hydroxy acid as a product from the incubation of arachidonic acid with washed blood platelets

1979 • 59 citations

Subcellular localization and some properties of lipoxygenase activity in human blood platelets

1984 • 59 citations

Paradoxical Inhibition of Insulin Secretion by Glucose in Human Diabetes Mellitus*

1979 • 58 citations

Determination of sulfidopeptide leukotrienes in biological fluids by gas chromatography mass spectrometry

1986 • 55 citations

Lipoxygenase- and cyclooxygenase-reaction products and incorporation into glycerolipids of radiolabeled arachidonic acid in the bovine retina

1984 • 54 citations

Platelet Glutathione and Thromboxane Synthesis in Diabetes

1985 • 53 citations

Metabolism of leukotriene A4 into C4 by human platelets

1986 • 53 citations

Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase

1985 • 52 citations

Effects on Glucose-induced Insulin Secretion of Lipoxygenase-derived Metabolites of Arachidonic Acid

1984 • 51 citations

Metabolism of 7,10,13,16-docosatetraenoic to dihomo-thromboxane 14-hydroxy-7,10,12-nonadecatrienoic acid hydroxy fatty acids by human platelets

1985 • 50 citations

Characterization of monohydroxylated lipoxygenase metabolites of arachidonic and linoleic acid in rabbit peritoneal tissue

1982 • 48 citations

Is phospholipase A2 a “glucose sensor” responsible for the phasic pattern of insulin release?

1984 • 48 citations

Comparison of the in vitro effect of eicosapentaenoic acid (EPA)-derived lipoxygenase metabolites on human platelet function with those of arachidonic acid

1986 • 47 citations

[6] Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes

1982 • 46 citations

15‐hydroperoxyeicosatetraenoic acid inhibits human platelet aggregation

1980 • 44 citations

LIPOXYGENASE PATHWAYS

1983 • 44 citations

Vitamin E exerts antiaggregatory effects without inhibiting the enzymes of the arachidonic acid cascade in platelets

1986 • 43 citations

[7] Arachidonic acid-12-lipoxygenase from bovine platelets

1982 • 43 citations

Leukotrienes and other lipoxygenase products of arachidonic acid synthesized in the kidney

1986 • 42 citations

MEASUREMENT OF EICOSANOIDS BY BIOASSAY AND RADIOIMMUNOASSAY

1983 • 42 citations

Measurement of prostaglandins, thromboxanes and hydroxy fatty acids by stable isotope dilution gas chromatography/mass spectrometry

1987 • 40 citations

Enhancement of eicosaenoic acid lipoxygenation in human platelets by 12‐hydroperoxy derivative of arachidonic acid

1985 • 38 citations

Human salivary eicosanoids: Circadian variation

1983 • 38 citations

Increased arachidonic acid incorporation into platelet phospholipids in Type 2 (non-insulin-dependent) diabetes

1984 • 38 citations

Vitamin E inhibits the release of calcium from a platelet membrane fraction in vitro

1979 • 37 citations

Regulation of Human Natural Killing

1986 • 36 citations

Production of 12-hydroxyeicosatetraenoic acid and vitamin E status in platelets from type I human diabetic subjects

1985 • 35 citations

Transformation of arachidonic acid in the rat anterior pituitary

1982 • 33 citations

Effects of Hydroxyeicosatetraenoic Acids on Fatty Acid Esterification in Phospholipids and Insulin Secretion in Pancreatic Islets*

1985 • 31 citations

Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva

1983 • 30 citations

Endotoxin-induced changes in pulmonary hemodynamics and respiratory mechanics. Role of lipoxygenase and cyclooxygenase products.

1986 • 30 citations

The lipoxygenase product, 5-hydroperoxy-arachidonic acid, augments chemotactic peptide-stimulated arachidonic acid release from HL60 granulocytes

1982 • 30 citations

Vitamin E and the inhibition of platelet lipoxygenase.

1980 • 29 citations

Production of arachidonic acid lipoxygenase products during platelet-neutrophil interactions.

1984 • 28 citations

High performance liquid chromatography (HPLC) of arachidonic acid metabolites

1982 • 26 citations

Quantitative measurement of 5-, 12-, and 15-hydroxyeicosatetraenoic acid together with 12-hydroxyheptadecatrienoic acid by stable isotope dilution gas chromatography-negative ion chemical ionization-mass spectrometry

1987 • 26 citations

The 5-lipoxygenase products can modulate the synthesis of platelet-activating factor (alkyl-acetyl GPC) in Ca-ionophore A23187-stimulated rat peritoneal macrophages

1985 • 26 citations

Platelet glutathione and thromboxane synthesis in diabetes

1985 • 26 citations

Preparation of18O-labelled standards of hydroxy-eicosatetraenoic acids and thromboxanes for quantitative measurement by gas chromatography/mass spectrometry

1986 • 26 citations

Metabolism of 4,7,10,13,16-docosapentaenoic acid by human platelet cyclooxygenase and lipoxygenase

1985 • 26 citations

Effects on glucose-induced insulin secretion of lipoxygenase-derived metabolites of arachidonic acid

1984 • 23 citations

Cyclooxygenase and lipoxygenase metabolites during platelet aggregation: Quantitative measurement by negative ion chemical ionization — gas chromatography / mass spectrometry

1987 • 22 citations

Biochemical interaction of arachidonic acid and vitamin e in human platelets

1983 • 20 citations

The effects of lipoxygenase inhibitors in anaphylactic and inflammatory responses in vivo

1984 • 19 citations

Inhibition of platelet function in thrombosis.

1985 • 17 citations

Double bond requirement for the 5-lipoxygenase pathway

1985 • 16 citations

Transitory stimulation of human platelet 12-lipooxygenase by vitamin E supplementation

1986 • 14 citations

Metabolism of (n-6) and (n-3) polyunsaturated fatty acids by human platelets

1986 • 12 citations

An Inhibitor of Lipoxygenase, Nordihydroguaiaretic Acid, Shortens Actin Filaments1

1984 • 11 citations

The occurrence of a lipoxygenase pathway in reticulocytes of various species.

1986 • 7 citations

Measurement of 5-lipoxygenase products in the lung.

1985 • 7 citations

Enzymatic Formation of Leukotrienes

1985 • 5 citations

Hydroperoxide Metabolism and Oxidant Generation in Platelets

1985 • 2 citations

Influence of vitamin E on platelet survival.

1985 • 2 citations

Deleted Work

1955 • 0 citations