Immunopathogenesis and immunotherapy in AIDS virus infections

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

Antibody neutralization and escape by HIV-1

2003 • 2,384 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1994 • 1,899 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

Positive Effects of Combined Antiretroviral Therapy on CD4 ⁺ T Cell Homeostasis and Function in Advanced HIV Disease

1997 • 1,812 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

2003 • 1,466 citations

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

1999 • 1,428 citations

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

1998 • 1,426 citations

Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

2000 • 1,247 citations

HIV preferentially infects HIV-specific CD4+ T cells

2002 • 1,246 citations

HLA and HIV-1: Heterozygote Advantage and B*35 - Cw*04 Disadvantage

1999 • 1,229 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

2003 • 1,192 citations

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

2002 • 1,180 citations

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1997 • 1,135 citations

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

2001 • 1,128 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

Immune control of HIV-1 after early treatment of acute infection

2000 • 1,012 citations

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

1998 • 1,012 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

2000 • 990 citations

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

2002 • 986 citations

Kaposis sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California.

1981 • 963 citations

Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection

1996 • 959 citations

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination

2000 • 901 citations

The Selective Downregulation of Class I Major Histocompatibility Complex Proteins by HIV-1 Protects HIV-Infected Cells from NK Cells

1999 • 870 citations

Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian–human immunodeficiency virus infection

2000 • 861 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1999 • 766 citations

Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level

2002 • 754 citations

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

1997 • 696 citations

Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

2001 • 693 citations

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

2000 • 693 citations

Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load

2003 • 674 citations

Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

2002 • 670 citations

Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III

1985 • 629 citations

Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein.

1989 • 628 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

A role for carbohydrates in immune evasion in AIDS

1998 • 562 citations

Evolution and transmission of stable CTL escape mutations in HIV infection

2001 • 549 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG

1995 • 483 citations

Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS

2001 • 477 citations

Contribution of Human α-Defensin 1, 2, and 3 to the Anti-HIV-1 Activity of CD8 Antiviral Factor

2002 • 475 citations

Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients

1985 • 448 citations

Increases in CD4 T Lymphocytes with Intermittent Courses of Interleukin-2 in Patients with Human Immunodeficiency Virus Infection — A Preliminary Study

1995 • 430 citations

Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera

1990 • 416 citations

Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120

1995 • 405 citations

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8⁺and CD4⁺T lymphocytes

2000 • 392 citations

Cellular Immune Responses and Viral Diversity in Individuals Treated during Acute and Early HIV-1 Infection

2001 • 390 citations

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

1995 • 383 citations

Advantage of rare HLA supertype in HIV disease progression

2003 • 351 citations

Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy

1999 • 350 citations

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

1997 • 345 citations

In vivo migration and function of transferred HIV-1-specific cytotoxic T cells

1999 • 341 citations

β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1998 • 334 citations

Neutralizing Antibody Responses to Human Immunodeficiency Virus Type 1 in Primary Infection and Long‐Term‐Nonprogressive Infection

1997 • 327 citations

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus

2002 • 303 citations

Emergence of CTL Coincides with Clearance of Virus During Primary Simian Immunodeficiency Virus Infection in Rhesus Monkeys

1999 • 278 citations

Neutralizing and Infection-Enhancing Antibody Responses to Human Immunodeficiency Virus Type 1 in Long-Term Nonprogressors

1996 • 262 citations

Substantial Differences in Specificity of HIV-Specific Cytotoxic T Cells in Acute and Chronic HIV Infection

2001 • 261 citations

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes.

1989 • 258 citations

Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation

2002 • 249 citations

Neutralizing Antibodies Have Limited Effects on the Control of Established HIV-1 Infection In Vivo

1999 • 243 citations

Therapeutic dendritic-cell vaccine for simian AIDS

2002 • 239 citations

ALVAC-SIV-gag-pol-env-Based Vaccination and Macaque Major Histocompatibility Complex Class I (A*01) Delay Simian Immunodeficiency Virus SIV_mac-Induced Immunodeficiency

2002 • 235 citations

Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection

2001 • 233 citations

Autologous and heterologous neutralizing antibody responses following initial seroconversion in human immunodeficiency virus type 1-infected individuals

1997 • 225 citations

Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys

1993 • 218 citations

Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection

2002 • 218 citations

High-level HIV-1 viremia suppresses viral antigen-specific CD4⁺T cell proliferation

2001 • 215 citations

Early Therapy of Vertical Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Control of Viral Replication and Absence of Persistent HIV-1-Specific Immune Responses

2000 • 211 citations

The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection

2001 • 193 citations

Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic

2002 • 187 citations

Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene

1988 • 186 citations

Persistent numbers of tetramer+ CD8+ T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS

2002 • 186 citations

Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus

1993 • 185 citations

Effect of Combination Antiretroviral Therapy on T‐Cell Immunity in Acute Human Immunodeficiency Virus Type 1 Infection

2000 • 159 citations

Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.

1998 • 156 citations

Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile

1996 • 150 citations

Immunization with a Modified Vaccinia Virus Expressing Simian Immunodeficiency Virus (SIV) Gag-Pol Primes for an Anamnestic Gag-Specific Cytotoxic T-Lymphocyte Response and Is Associated with Reduction of Viremia after SIV Challenge

2000 • 145 citations

Enhanced Detection of Human Immunodeficiency Virus Type 1-Specific T-Cell Responses to Highly Variable Regions by Using Peptides Based on Autologous Virus Sequences

2003 • 145 citations

Effect of Humoral Immune Responses on Controlling Viremia during Primary Infection of Rhesus Monkeys with Simian Immunodeficiency Virus

2003 • 144 citations

Weak anti-HIV CD8+ T-cell effector activity in HIV primary infection

1999 • 141 citations

Discontinuation of Antiretroviral Therapy Commenced Early during the Course of Human Immunodeficiency Virus Type 1 Infection, with or without Adjunctive Vaccination

2002 • 139 citations

Human Immunodeficiency Virus-Specific Circulating CD8 T Lymphocytes Have Down-Modulated CD3ζ and CD28, Key Signaling Molecules for T-Cell Activation

2000 • 126 citations

Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice.

1990 • 119 citations

Potent and synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12

1997 • 119 citations

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

2001 • 118 citations

Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes

2002 • 115 citations

Polymorphisms in HLA Class I Genes Associated with both Favorable Prognosis of Human Immunodeficiency Virus (HIV) Type 1 Infection and Positive Cytotoxic T-Lymphocyte Responses to ALVAC-HIV Recombinant Canarypox Vaccines

2001 • 103 citations

Lack of Viral Escape and Defective In Vivo Activation of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes in Rapidly Progressive Infection

1999 • 94 citations

T cell receptor V beta repertoire in an acute infection of rhesus monkeys with simian immunodeficiency viruses and a chimeric simian-human immunodeficiency virus.

1995 • 80 citations

Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection

2002 • 79 citations

In vivo persistence of a HIV‐1‐encoded HLA‐B27‐restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity

1991 • 78 citations

Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection

2002 • 67 citations

Global Dysfunction of CD4 T-Lymphocyte Cytokine Expression in Simian-Human Immunodeficiency Virus/SIV-Infected Monkeys Is Prevented by Vaccination

2003 • 28 citations

Passive immunization for the treatment of HIV infection.

1998 • 10 citations

Prolonged Dominance of Clonally Restricted CD4⁺T Cells in Macaques Infected with Simian Immunodeficiency Viruses

2000 • 6 citations