Peripheral γδ T-lymphocytes as an innovative tool in immunotherapy for metastatic renal cell carcinoma

Tumour-educated macrophages promote tumour progression and metastasis

2004 • 3,259 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy.

1995 • 1,320 citations

Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate

1993 • 1,158 citations

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

1998 • 1,134 citations

γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection

2000 • 1,107 citations

Natural and synthetic non-peptide antigens recognized by human γδ T cells

1995 • 974 citations

Recombinant Human Interleukin-2, Recombinant Human Interferon Alfa-2a, or Both in Metastatic Renal-Cell Carcinoma

1998 • 962 citations

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

2005 • 916 citations

Classification of renal cell carcinoma

1997 • 887 citations

Randomized Phase III Trial of High-Dose Interleukin-2 Versus Subcutaneous Interleukin-2 and Interferon in Patients With Metastatic Renal Cell Carcinoma

2004 • 801 citations

Human T Cell Receptor γδ Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells

2003 • 782 citations

Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands

1994 • 685 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Professional Antigen-Presentation Function by Human γδ T Cells

2005 • 668 citations

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

2000 • 652 citations

Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma

2000 • 630 citations

SYSTEMIC THERAPY FOR RENAL CELL CARCINOMA

2000 • 610 citations

γδ T cells for immune therapy of patients with lymphoid malignancies

2003 • 525 citations

Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire.

1990 • 510 citations

Novel mutations of the MET proto-oncogene in papillary renal carcinomas

1999 • 502 citations

Prominence of γδ T cells in the ruminant immune system

1991 • 427 citations

Renal cell carcinoma.

2006 • 382 citations

Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea

1999 • 368 citations

Self-Recognition of Cd1 by γ/δ T Cells

2000 • 367 citations

Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43–9006) in patients with advanced renal cell carcinoma (RCC)

2005 • 358 citations

Recognition by Human V _γ 9/V _δ 2 T Cells of a GroEL Homolog on Daudi Burkitt's Lymphoma Cells

1990 • 357 citations

Identification of (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl pyrophosphate as a major activator for human γδ T cells in Escherichia coli

2001 • 330 citations

Implication of γδ T cells in the human immune response to cytomegalovirus

1999 • 316 citations

Tumor Recognition following Vγ9Vδ2 T Cell Receptor Interactions with a Surface F1-ATPase-Related Structure and Apolipoprotein A-I

2005 • 281 citations

Phase iii randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma

1995 • 278 citations

V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.

1995 • 276 citations

Genetic Basis of Cancer of the Kidney

2004 • 247 citations

Structure of a human γδ T-cell antigen receptor

2001 • 243 citations

Patterns of Human Tumor-Infiltrating Lymphocytes in 120 Human Cancers

1990 • 240 citations

Induction of γδ T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo

2003 • 239 citations

Multicenter, Randomized, Phase III Trial of CD8⁺ Tumor-Infiltrating Lymphocytes in Combination With Recombinant Interleukin-2 in Metastatic Renal Cell Carcinoma

1999 • 212 citations

Vγ9Vδ2 T Cell Response to Colon Carcinoma Cells

2005 • 194 citations

In Vivo Immunomanipulation of Vγ9Vδ2 T Cells with a Synthetic Phosphoantigen in a Preclinical Nonhuman Primate Model

2005 • 187 citations

Phosphostim-Activated γδ T Cells Kill Autologous Metastatic Renal Cell Carcinoma

2005 • 179 citations

Phase 1 Study in Patients With Metastatic Melanoma of Immunization With Dendritic Cells Presenting Epitopes Derived From the Melanoma-Associated Antigens MART-1 and gp100

2000 • 179 citations

Effect of gemcitabine on immune cells in subjects with adenocarcinoma of the pancreas

2005 • 168 citations

Human γδ T Cells Induce Dendritic Cell Maturation

2002 • 166 citations

Recombinant alfa interferon in renal cell carcinoma: a randomized trial of two routes of administration.

1987 • 165 citations

Patterns of Chemokine Receptor Expression on Peripheral Blood γδ T Lymphocytes: Strong Expression of CCR5 Is a Selective Feature of Vδ2/Vγ9 γδ T Cells

2002 • 152 citations

Characterization of Tumor Reactivity of Human Vγ9Vδ2 γδ T Cells In Vitro and in SCID Mice In Vivo

2004 • 150 citations

Chemical Synthesis and Biological Activity of Bromohydrin Pyrophosphate, a Potent Stimulator of Human γδ T Cells

2001 • 148 citations

Targeting of Tumor Cells for Human γδ T Cells by Nonpeptide Antigens

2001 • 146 citations

Spontaneous regression of metastases of renal cancer: A report of two cases including the first recorded regression following irradiation of a dominant metastasis and review of the world literature

1981 • 145 citations

Lymphotoxin-Mediated Regulation of γδ Cell Differentiation by αß T Cell Progenitors

2004 • 143 citations

Risk factors for adult renal cell carcinoma: a systematic review and implications for prevention

2000 • 132 citations

Close correlation between Daudi and mycobacterial antigen recognition by human gamma delta T cells and expression of V9JPC1 gamma/V2DJC delta-encoded T cell receptors.

1993 • 131 citations

Plasmodium falciparum stimuli for human gammadelta T cells are related to phosphorylated antigens of mycobacteria

1996 • 131 citations

Interleukin-2 with or without LAK cells in metastatic renal cell carcinoma: a report of a European multicentre study.

1989 • 109 citations

Vγ9/Vδ2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-d-xylulose 5-phosphate pathway of isoprenoid biosynthesis

1999 • 94 citations

EX VIVO EXPANDED HUMAN Vλ9Vδ2+ λδ-T CELLS MEDIATE INNATE ANTITUMOR ACTIVITY AGAINST HUMAN PROSTATE CANCER CELLS IN VITRO

2005 • 91 citations

Recovery of CD8+ T-Cell Function During Systemic Chemotherapy in Advanced Ovarian Cancer

2005 • 82 citations

A chemical basis for recognition of nonpeptide antigens by human γδ T cells*

2000 • 80 citations

Human Vγ2Vδ2 T Cells Produce IFN-γ and TNF-α with an On/Off/On Cycling Pattern in Response to Live Bacterial Products

2001 • 80 citations

Sensing cell stress and transformation through Vγ9Vδ2 T cell-mediated recognition of the isoprenoid pathway metabolites

2005 • 80 citations

Gamma /delta T cells provide innate immunity against renal cell carcinoma

2001 • 78 citations

Killing of Laminin Receptor-Positive Human Lung Cancers by Tumor-Infiltrating Lymphocytes Bearing γδ + T-Cell Receptors

1996 • 64 citations

Anti-tumor effects of human peripheral ?? T cells in a mouse tumor model

2001 • 64 citations

Placebo‐associated remissions in a multicentre, randomized, double‐blind trial of interferon γ‐1b for the treatment of metastatic renal cell carcinoma

2000 • 58 citations

In vitro interleukin 12 activation of peripheral blood CD3(+)CD56(+) and CD3(+)CD56(-) gammadelta T cells from glioblastoma patients.

1997 • 54 citations

Immunotherapy with interleukin-2 (IL2) and lymphokine-activated natural killer cells: Improvement of clinical responses in metastatic renal cell carcinoma patients previously treated with IL2

1994 • 54 citations

Escherichia coli Produces Phosphoantigens Activating Human γδ T Cells

2002 • 51 citations

Renal cell carcinoma

2001 • 51 citations

Human γδ T Lymphocytes Exert Natural and IL–2–Induced Cytotoxicity to Neuroblastoma Cells

2000 • 50 citations

Antilymphoma activity of human gamma delta T-cells in mice with severe combined immune deficiency.

1992 • 49 citations

The genetic basis of renal cell carcinoma

2003 • 45 citations

New treatments for metastatic kidney cancer.

2005 • 36 citations

Vδ2+ γδ T Lymphocytes Are Cytotoxic to the MCF 7 Breast Carcinoma Cell Line and Can Be Detected among the T Cells That Infiltrate Breast Tumors

1993 • 35 citations

A simple method for the propagation and purification of γδT cells from the peripheral blood of glioblastoma patients using solid-phase anti-CD3 antibody and soluble IL-2

1997 • 32 citations

Specific Activation of Human Peripheral Blood γ/δ⁺ T Lymphocytes by Sonicated Antigens of Mycobacterium tuberculosis: Role In Vitro in Killing Human Bladder Carcinoma Cell Lines

1993 • 28 citations

Early Expression of a Functional TCRβ Chain Inhibits TCRγ Gene Rearrangements without Altering the Frequency of TCRγδ Lineage Cells

2004 • 25 citations

Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 γ δ T lymphocytes

2002 • 20 citations

High-Dose Interleukin-2 Two Days a Week for Metastatic Renal Cell Carcinoma

1994 • 14 citations

Phase I clinical trial of BromoHydrin PyroPhosphate, BrHPP (Phosphostim), a Vγ9Vδ2 T lymphocytes agonist in combination with low dose Interleukin-2 in patients with solid tumors

2005 • 11 citations

The Identification of Renal Cell Carcinoma as a Target for Allogeneic Based Cancer Immunotherapy

2002 • 10 citations

Lymphadenectomy for renal cell carcinoma

2005 • 7 citations

Deleted Work

1955 • 0 citations