Genetic Basis of Cancer of the Kidney

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

Liver Regeneration

1997 • 2,731 citations

Mutations of the VHL tumour suppressor gene in renal carcinoma

1994 • 1,719 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

2002 • 1,541 citations

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

2000 • 1,527 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

The Genetic Basis of Human Cancer

1997 • 1,113 citations

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

2002 • 882 citations

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

2002 • 754 citations

Hereditary Multiple Fibrofolliculomas With Trichodiscomas and Acrochordons

1977 • 711 citations

Inherited susceptibility to uterine leiomyomas and renal cell cancer

2001 • 641 citations

Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

2000 • 635 citations

Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

2002 • 633 citations

Mutations in the Fumarate Hydratase Gene Cause Hereditary Leiomyomatosis and Renal Cell Cancer in Families in North America

2003 • 605 citations

Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

1998 • 595 citations

Renal Tumors in the Birt-Hogg-Dubé Syndrome

2002 • 578 citations

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

1995 • 571 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Novel mutations of the MET proto-oncogene in papillary renal carcinomas

1999 • 502 citations

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1997 • 490 citations

Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dubé syndrome.

2002 • 481 citations

The Genetic Basis of Cancer of the Kidney

2003 • 463 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.

2002 • 448 citations

Activating mutations for the Met tyrosine kinase receptor in human cancer

1997 • 441 citations

The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

2002 • 438 citations

Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation

1998 • 377 citations

Birt-Hogg-Dubé Syndrome

1999 • 366 citations

Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.

2003 • 318 citations

HGF/SF‐met signaling in the control of branching morphogenesis and invasion

2003 • 312 citations

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer

2004 • 310 citations

Hereditary Papillary Renal Cell Carcinoma

1994 • 310 citations

Hypoxia‐induced activation of HIF‐1: role of HIF‐1α‐Hsp90 interaction

1999 • 309 citations

Topoisomerase I-Mediated Inhibition of Hypoxia-Inducible Factor 1

2004 • 291 citations

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

1998 • 285 citations

Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer

1995 • 259 citations

Hereditary and Sporadic Papillary Renal Carcinomas with c-met Mutations Share a Distinct Morphological Phenotype

1999 • 255 citations

Kinase Inhibition with BAY 43–9006 in Renal Cell Carcinoma

2004 • 246 citations

Specific Genetic Change in Tumors Associated With von Hippel-Lindau Disease

1989 • 222 citations

Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients.

1996 • 187 citations

Tyrosine kinase receptors as attractive targets of cancer therapy

2003 • 187 citations

Prevalence of Microscopic lesions in Grossly Normal Renal Parenchyma from Patients with von Hippel-Lindau Disease, Sporadic Renal Cell Carcinoma and No Renal Disease: Clinical Implications

1995 • 185 citations

Original Articles: Kidney Cancer: Hereditary Papillary Renal Cell Carcinoma: Clinical Studies in 10 Families

1995 • 163 citations

Overexpression of KIT in chromophobe renal cell carcinoma

2003 • 162 citations

Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3

1990 • 154 citations

Characterization of the Renal Pathology of a Familial Form of Renal Cell Carcinoma Associated With Von Hippel-Lindau Disease: Clinical and Molecular Genetic Implications

1995 • 153 citations

Inactivation of BHD in sporadic renal tumors.

2003 • 141 citations

Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons

1977 • 134 citations

Reduction of Hypoxia-Induced Transcription through the Repression of Hypoxia-Inducible Factor-1α/Aryl Hydrocarbon Receptor Nuclear Translocator DNA Binding by the 90-kDa Heat-Shock Protein Inhibitor Radicicol

2002 • 116 citations

Potent Blockade of Hepatocyte Growth Factor-stimulated Cell Motility, Matrix Invasion and Branching Morphogenesis by Antagonists of Grb2 Src Homology 2 Domain Interactions

2001 • 97 citations

[Cancer of the kidney].

1950 • 80 citations

A distinct expression pattern and point mutation of c-kit in papillary renal cell carcinomas

2004 • 57 citations

VHL: A very hip ligase

1999 • 51 citations

Tyrosine Kinase Inhibitors in Renal Cell Carcinoma

2004 • 30 citations

Deleted Work

1955 • 0 citations