Sensing cell stress and transformation through Vγ9Vδ2 T cell-mediated recognition of the isoprenoid pathway metabolites

Roles of the NKG2D immunoreceptor and its ligands

2003 • 1,297 citations

Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs

1999 • 1,175 citations

The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants†

1999 • 1,128 citations

Natural and synthetic non-peptide antigens recognized by human γδ T cells

1995 • 974 citations

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

2001 • 863 citations

Human T Cell Receptor γδ Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells

2003 • 782 citations

Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands

1994 • 685 citations

Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma

2000 • 630 citations

γδ T cells for immune therapy of patients with lymphoid malignancies

2003 • 525 citations

Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire.

1990 • 510 citations

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells

1995 • 468 citations

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

2002 • 448 citations

The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms

1998 • 432 citations

Cross-talk between the Cytosolic Mevalonate and the Plastidial Methylerythritol Phosphate Pathways in Tobacco Bright Yellow-2 Cells

2003 • 418 citations

Autoreactivity by design: innate B and T lymphocytes

2001 • 409 citations

MICA Engagement by Human Vγ2Vδ2 T Cells Enhances Their Antigen-Dependent Effector Function

2001 • 394 citations

Nonpeptide ligands for human gamma delta T cells.

1994 • 373 citations

Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells

2003 • 370 citations

Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea

1999 • 368 citations

Recognition by Human V _γ 9/V _δ 2 T Cells of a GroEL Homolog on Daudi Burkitt's Lymphoma Cells

1990 • 357 citations

Identification of (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl pyrophosphate as a major activator for human γδ T cells in Escherichia coli

2001 • 330 citations

A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition

2002 • 257 citations

Recognition of heat shock proteins and γΔ cell function

1990 • 247 citations

The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways

2000 • 243 citations

Structure of a human γδ T-cell antigen receptor

2001 • 243 citations

Induction of γδ T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo

2003 • 239 citations

Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future

2004 • 229 citations

Statins Prevent Bisphosphonate-Induced γ,δ-T-Cell Proliferation and Activation In Vitro

2004 • 212 citations

Early activation of human V gamma 9V delta 2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands.

1995 • 177 citations

Essential Requirement of Antigen Presentation by Monocyte Lineage Cells for the Activation of Primary Human γδ T Cells by Aminobisphosphonate Antigen

2001 • 174 citations

Human Vγ9‐Vδ2 cells are stimulated in a crossreactive fashion by a variety of phosphorylated metabolites

1995 • 168 citations

CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes.

1997 • 156 citations

Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors

2004 • 152 citations

Control of self‐reactive cytotoxic T lymphocytes expressing γδ T cell receptors by natural killer inhibitory receptors

1997 • 151 citations

Targeting of Tumor Cells for Human γδ T Cells by Nonpeptide Antigens

2001 • 146 citations

A novel ligand in lymphocyte-mediated cytotoxicity: expression of the beta subunit of H+ transporting ATP synthase on the surface of tumor cell lines.

1994 • 140 citations

Plasmodium falciparum stimuli for human gammadelta T cells are related to phosphorylated antigens of mycobacteria

1996 • 131 citations

Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma

2000 • 126 citations

Crucial role of TCR gamma chain junctional region in prenyl pyrophosphate antigen recognition by gamma delta T cells.

1998 • 122 citations

Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vγ9/Vδ2 T cells in tumor immunity

1997 • 120 citations

3-Formyl-1-butyl Pyrophosphate A Novel Mycobacterial Metabolite-activating Human γδ T Cells

1999 • 114 citations

Expansion of Vγ9Vδ2 T Cells Is Triggered byFrancisella tularensis-Derived Phosphoantigens in Tularemia but Not after Tularemia Vaccination

1998 • 111 citations

Functional characterization of GcpE, an essential enzyme of the non‐mevalonate pathway of isoprenoid biosynthesis

2002 • 108 citations

Crucial Role of TCRγ Chain Junctional Region in Prenyl Pyrophosphate Antigen Recognition by γδ T Cells

1998 • 107 citations

Essential Contribution of Germline-Encoded Lysine Residues in Jγ1.2 Segment to the Recognition of Nonpeptide Antigens by Human γδ T Cells

2001 • 86 citations

Cutting Edge: Human γδ T Cells Are Activated by Intermediates of the 2-C-methyl-<scp>d</scp>-erythritol 4-phosphate Pathway of Isoprenoid Biosynthesis

2001 • 81 citations

Polyinosinic‐polycytidylic acid‐mediated stimulation of human γδ T cells via CD11c⁺ dendritic cell‐derived type I interferons

2004 • 68 citations

Recognition of nonpeptide prenyl pyrophosphate antigens by human γδ T cells

1999 • 68 citations

Inhibitory MHC class I receptors on γδ T cells in tumour immunity and autoimmunity

2000 • 58 citations

Innate T-cell immunity to nonpeptidic antigens

1998 • 54 citations

Escherichia coli Produces Phosphoantigens Activating Human γδ T Cells

2002 • 51 citations

Analysis of the activating receptors and cytolytic function of human natural killer cells undergoing in vivo differentiation after allogeneic bone marrow transplantation

2004 • 49 citations

Y2K+1 state-of-the-art on non-peptide phosphoantigens, a novel category of immunostimulatory molecules

2001 • 35 citations

T cell target 1 (TCT.1): a novel target molecule for human non-major histocompatibility complex-restricted T lymphocytes.

1990 • 35 citations

Activation of human γδ T-cell by heat-treated mistletoe plant extracts

1996 • 26 citations

Activation and control of self-reactive γδ T cells

1999 • 14 citations

Conventional and non-conventional recognition of non-peptide antigens by T lymphocytes

1999 • 6 citations