Multicenter, Randomized, Phase III Trial of CD8⁺ Tumor-Infiltrating Lymphocytes in Combination With Recombinant Interleukin-2 in Metastatic Renal Cell Carcinoma

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy.

1995 • 1,320 citations

Treatment of 283 Consecutive Patients With Metastatic Melanoma or Renal Cell Cancer Using High-Dose Bolus Interleukin 2

1994 • 1,070 citations

The Natural History of Metastatic Renal Cell Carcinoma: A Computer Analysis

1978 • 531 citations

Renal Cell Carcinoma: Long-Term Survival and Late Recurrence

1981 • 497 citations

Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study.

1988 • 432 citations

Metastatic Renal Cancer Treated with Interleukin-2 and Lymphokine-Activated Killer Cells

1988 • 353 citations

TUMOUR-INFILTRATING LYMPHOCYTES AND INTERLEUKIN-2 IN TREATMENT OF ADVANCED CANCER

1989 • 337 citations

Renal cell carcinoma: Survival and prognostic factors

1986 • 323 citations

Interleukin 2 expanded tumor-infiltrating lymphocytes in human renal cell cancer: isolation, characterization, and antitumor activity.

1988 • 302 citations

In Vivo Antitumor Activity of Tumor-Infiltrating Lymphocytes Expanded in Recombinant Interleukin-2

1987 • 250 citations

Randomized phase II trial of high-dose interleukin-2 either alone or in combination with interferon alfa-2b in advanced renal cell carcinoma.

1993 • 211 citations

Randomized comparison of high-dose and low-dose intravenous interleukin-2 for the therapy of metastatic renal cell carcinoma: an interim report.

1994 • 179 citations

Treatment of Metastatic Renal Cell Carcinoma With Nephrectomy, Interleukin-2 and Cytokine-Primed or CD8(+) Selected Tumor Infiltrating Lymphocytes from Primary Tumor

1997 • 162 citations

Stratification of risk factors in renal cell carcinoma

1983 • 157 citations

Stratification of risk factors in renal cell carcinoma

1983 • 144 citations

Validation of the Tumor, Nodes and Metastasis Classification of Renal Cell Carcinoma

1985 • 140 citations

Subcutaneous interleukin-2 plus interferon alfa-2a in metastatic renal cancer: an outpatient multicenter trial.

1993 • 139 citations

The Impact Of Adjuvant Nephrectomy On Multimodality Treatment Of Metastatic Renal Cell Carcinoma

1994 • 129 citations

Combination Immunotherapy for Cancer:Synergistic Antitumor Interactions of Interleukin-2, Alfa Interferon, and Tumor-Infiltrating Lymphocytes

1988 • 128 citations

Clinical results and characterization of tumor-infiltrating lymphocytes with or without recombinant interleukin 2 in human metastatic renal cell carcinoma.

1991 • 103 citations

Extended continuous infusion low-dose recombinant interleukin-2 in advanced cancer: prolonged immunomodulation without significant toxicity.

1991 • 101 citations

Characterization of the cytolytic activity of CD4+ and CD8+ tumor-infiltrating lymphocytes in human renal cell carcinoma.

1990 • 91 citations

Therapy of renal cell carcinoma with interleukin-2 and lymphokine-activated killer cells: phase II experience with a hybrid bolus and continuous infusion interleukin-2 regimen.

1990 • 87 citations

Interferon- α Primed Tumor-Infiltrating Lymphocytes Combined with Interleukin-2 and Interferon- α as Therapy for Metastatic Renal Cell Carcinoma

1993 • 75 citations

Outpatient subcutaneous interleukin-2 and interferon-alpha for metastatic renal cell cancer: five-year follow-up of the Cytokine Working Group Study.

1997 • 73 citations

In vivo trafficking of adoptively transferred interleukin-2 expanded tumor-infiltrating lymphocytes and peripheral blood lymphocytes. Results of a double gene marking trial.

1996 • 72 citations

The clinical effects of prolonged treatment of patients with advanced cancer with low-dose subcutaneous interleukin-2

1991 • 69 citations

Cytoreductive surgery in the management of metastatic renal cell carcinoma: the UCLA experience.

1996 • 63 citations

A Randomized Study of Low-Dose Interleukin-2 Subcutaneous Immunotherapy versus Interleukin-2 plus Interferon-Alpha as First Line Therapy for Metastatic Renal Cell Carcinoma

1993 • 29 citations

Natural Immune Reactivity-Associated Therapeutic Response in Patients with Metastatic Renal Cell Carcinoma Receiving Tumor-Infiltrating Lymphocytes and Interleukin-2-Based Therapy

1996 • 26 citations

Role of surgery in patients with metastatic renal cell carcinoma.

1996 • 26 citations

Patterns of Cytokine Release of Unselected and CD8+ Selected Renal Cell Carcinoma Tumor-Infiltrating Lymphocytes (TIL)

1994 • 20 citations

Adenovirus-Mediated Interleukin-2 Production by Tumors Induces Growth of Cytotoxic Tumor-Infiltrating Lymphocytes Against Human Renal Cell Carcinoma

1998 • 16 citations