Human T Cell Receptor γδ Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells

Regulation of the mevalonate pathway

1990 • 5,282 citations

Structural Mechanism for Statin Inhibition of HMG-CoA Reductase

2001 • 1,514 citations

Natural and synthetic non-peptide antigens recognized by human γδ T cells

1995 • 974 citations

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

2001 • 863 citations

Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands

1994 • 685 citations

Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma

2000 • 630 citations

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells

1995 • 468 citations

Sterols and Isoprenoids: Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway

1999 • 463 citations

Alendronate Is a Specific, Nanomolar Inhibitor of Farnesyl Diphosphate Synthase

2000 • 401 citations

Recognition by Human V _γ 9/V _δ 2 T Cells of a GroEL Homolog on Daudi Burkitt's Lymphoma Cells

1990 • 357 citations

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

1988 • 336 citations

Selection by two powerful antigens may account for the presence of the major population of human peripheral gamma/delta T cells.

1991 • 201 citations

Biology of the Human γ T‐Cell Receptor

1991 • 185 citations

Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1994 • 174 citations

Vγ2Vδ2 T-cell receptor–mediated recognition of aminobisphosphonates

2001 • 173 citations

Human Vγ9‐Vδ2 cells are stimulated in a crossreactive fashion by a variety of phosphorylated metabolites

1995 • 168 citations

Antigen recognition by human γδ T cells: pattern recognition by the adaptive immune system

2000 • 165 citations

Feedback and Hormonal Regulation of Hepatic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase: The Concept of Cholesterol Buffering Capacity

2000 • 159 citations

Sentinel function of broadly reactive human γδ T cells

1997 • 156 citations

Targeting of Tumor Cells for Human γδ T Cells by Nonpeptide Antigens

2001 • 146 citations

3-Formyl-1-butyl Pyrophosphate A Novel Mycobacterial Metabolite-activating Human γδ T Cells

1999 • 114 citations

HMG–CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P–glycoprotein–expressing cells

1996 • 106 citations

In vivo regulation of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase: increased enzyme protein concentration and catalytic efficiency in human leukemia and lymphoma.

1991 • 69 citations

Escherichia coli Produces Phosphoantigens Activating Human γδ T Cells

2002 • 51 citations

Antilymphoma activity of human gamma delta T-cells in mice with severe combined immune deficiency.

1992 • 49 citations

Reactivity of γδ T Cells Induced by the Tumour Cell Line RPMI 8226: Functional Heterogeneity of Clonal Populations and Role of GroEL Heat Shock Proteins

1992 • 45 citations

7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemli-Opitz syndrome skin fibroblasts

1998 • 44 citations

Activation of the cholesterol pathway and Ras maturation in response to stress

1999 • 37 citations

Epidermal Growth Factor Stimulates 3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase Expression via the ErbB-2 Pathway in Human Breast Adenocarcinoma Cells

1999 • 34 citations

Specific triggering of gamma, delta T cells by K562 activates the gamma, delta T cell receptor and may regulate natural killer-like function.

1991 • 18 citations

Deleted Work

1955 • 0 citations