Inducible production of interferon-γ in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

The Hedgehog and Wnt signalling pathways in cancer

2001 • 1,374 citations

Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

1999 • 1,313 citations

Sonic hedgehog regulates the growth and patterning of the cerebellum

1999 • 903 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Serine phosphorylation of STATs

2000 • 873 citations

Mutations in SUFU predispose to medulloblastoma

2002 • 796 citations

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

2002 • 788 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

Stat proteins and oncogenesis

2002 • 776 citations

Gli and hedgehog in cancer: tumours, embryos and stem cells

2002 • 709 citations

Stat proteins and oncogenesis

2002 • 660 citations

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

1999 • 646 citations

GFAP promoter directs astrocyte-specific expression in transgenic mice

1994 • 471 citations

The Developmental Biology of Brain Tumors

2001 • 462 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Signaling pathways activated by interferons

1999 • 268 citations

Sonic hedgehog in CNS development: one signal, multiple outputs

2002 • 259 citations

Targeted CNS Expression of Interferon-γ in Transgenic Mice Leads to Hypomyelination, Reactive Gliosis, and Abnormal Cerebellar Development

1996 • 184 citations

Constitutive activation of Stat3α in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)

2002 • 171 citations

Human developmental disorders and the Sonic hedgehog pathway

1998 • 163 citations

Evidence that haploinsufficiency ofPtch leads to medulloblastoma in mice

2000 • 159 citations

Treatment with gamma-interferon triggers the onset of collagen arthritis in mice

1988 • 158 citations

Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma

1992 • 146 citations

Distinct roles of PTCH2 splice variants in Hedgehog signalling

2004 • 94 citations

A mouse model for medulloblastoma and basal cell nevus syndrome.

2001 • 87 citations

The PKR protein kinase--an interferon-inducible regulator of cell growth and differentiation.

1997 • 81 citations

Regulation of Signal Transducer and Activator of Transcription and Suppressor of Cytokine-Signaling Gene Expression in the Brain of Mice with Astrocyte-Targeted Production of Interleukin-12 or Experimental Autoimmune Encephalomyelitis

2002 • 77 citations

Regional Hypomyelination and Dysplasia in Transgenic Mice with Astrocyte-Directed Expression of Interferon-γ

2000 • 77 citations

Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-α–stimulated STAT2-independent production of IFN-γ in the brain

2003 • 73 citations

Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus

1999 • 71 citations

RNAse protection assays for the simultaneous and semiquantitative analysis of multiple murine matrix metalloproteinase (MMP) and MMP inhibitor mRNAs

1997 • 39 citations

Neuronal Survival Strategies in the Face of RNA Viral Infection

2002 • 24 citations