Post-transcriptional regulation of sex determination in Caenorhabditis elegans: widespread expression of the sex-determining gene fem-1 in both sexes.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

NONDISJUNCTION MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1979 • 768 citations

Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosophila embryos: application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots

1984 • 668 citations

A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

1990 • 618 citations

Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila

1994 • 506 citations

Inactivation of gene expression in plants as a consequence of specific sequence duplication.

1994 • 462 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans.

1993 • 429 citations

DNA transformation.

1995 • 403 citations

A uniform genetic nomenclature for the nematode Caenorhabditis elegans

1979 • 382 citations

fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans.

1988 • 368 citations

The glp-1 locus and cellular interactions in early C. elegans embryos

1987 • 335 citations

The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types.

1989 • 321 citations

pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos

1995 • 314 citations

Characterization of a germ-line proliferation mutation in C. elegans

1992 • 309 citations

Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans.

1992 • 302 citations

Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans

1995 • 292 citations

A new kind of informational suppression in the nematode Caenorhabditis elegans.

1989 • 272 citations

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision

1994 • 254 citations

Operons as a common form of chromosomal organization in C. elegans

1994 • 245 citations

Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region

1991 • 237 citations

Gain-of-Function Mutations of fem-3, a Sex-Determination Gene in Caenorhabditis elegans

1987 • 236 citations

Molecular analysis of the C. elegans sex-determining gene tra-1: A gene encoding two zinc finger proteins

1992 • 233 citations

The ANK repeat: a ubiquitous motif involved in macromolecular recognition

1992 • 225 citations

Transgene and gene suppression: telling us something new?

1995 • 218 citations

A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegans

1984 • 216 citations

SEX DETERMINATION IN THE NEMATODE C. ELEGANS: ANALYSIS OF tra-3 SUPPRESSORS AND CHARACTERIZATION OF fem GENES

1986 • 210 citations

POLYPLOIDS AND SEX DETERMINATION IN CAENORHABDITIS ELEGANS

1979 • 194 citations

Identification of plant genetic loci involved in a posttranscriptional mechanism for meiotically reversible transgene silencing.

1994 • 184 citations

The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions

1990 • 176 citations

fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans.

1990 • 173 citations

Intersex, a temperature-sensitive mutant of the nematode Caenorhabditis elegans

1978 • 151 citations

The mec-7 beta-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons.

1992 • 149 citations

Development of the male reproductive system and sexual transformation in the nematode Caenorhabditis elegans

1976 • 139 citations

The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans.

1995 • 132 citations

Specification of male development in Caenorhabditis elegans: The fem genes

1984 • 131 citations

tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.

1992 • 127 citations

Elements Regulating Cell- and Stage-Specific Expression of the C. elegans MyoD Family Homolog hlh-1

1994 • 105 citations

Histochemical techniques for locating Escherichia coli β-galactosidase activity in transgenic organisms

1992 • 103 citations

The mog-1 gene is required for the switch from spermatogenesis to oogenesis in Caenorhabditis elegans.

1993 • 102 citations

elt-1, an embryonically expressed Caenorhabditis elegans gene homologous to the GATA transcription factor family.

1991 • 102 citations

Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation.

1994 • 101 citations

Homology-dependent gene silencing in transgenic plants: what does it really tell us?

1995 • 97 citations

Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination.

1993 • 96 citations

The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally.

1992 • 96 citations

Spatial Control of Gut-Specific Gene Expression During Caenorhabditis elegans Development

1991 • 91 citations

Sequences Within the Last Intron function in RNA 3'-End Formation in Cultured Cells

1993 • 88 citations

More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegans

1993 • 88 citations

The intron requirement for immunoglobulin gene expression is dependent upon the promoter

1988 • 87 citations

Zinc fingers in sex determination: only one of the twoC.elegansTra-1 proteins binds DNAin Vitro

1993 • 86 citations

elt-2, a Second GATA Factor from the Nematode Caenorhabditis elegans

1995 • 85 citations

Evidence from mosaic analysis of the masculinizing gene her–1for cell interactions inC. eleganssex determination

1992 • 81 citations

The C. elegans sex-determining gene fem-2 encodes a putative protein phosphatase.

1995 • 78 citations

The mec-3 gene contains cis-acting elements mediating positive and negative regulation in cells produced by asymmetric cell division in Caenorhabditis elegans.

1991 • 77 citations

Molecular cloning and transcript analysis of fem-3, a sex-determination gene in Caenorhabditis elegans.

1988 • 67 citations

Regulation of vitellogenin gene expression in transgenic Caenorhabditis elegans: short sequences required for activation of the vit-2 promoter.

1992 • 67 citations

Molecular genetics of sex determination in C. elegans

1992 • 66 citations

The Regulatory Hierarchy Controlling Sex Determination And Dosage Compensation IN

1990 • 64 citations

Problems and paradigms: Genetic sex determination mechanism and evolution

1992 • 60 citations

A predicted membrane protein, TRA-2A, directs hermaphrodite development in Caenorhabditis elegans

1995 • 47 citations

In vivo cooperation between introns during pre-mRNA processing.

1993 • 37 citations

PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors

1994 • 33 citations

elt-1, an Embryonically Expressed Caenorhabditis elegans Gene Homologous to the GATA Transcription Factor Family

1991 • 27 citations

A C. elegans mutant screen based on antibody or histochemical staining

1995 • 16 citations

Regulation of Vitellogenin Gene Expression in Transgenic Caenorhabditis elegans: Short Sequences Required for Activation of the vit-2 Promoter

1992 • 15 citations

Expression of the polyubiquitin-encoding gene (ubq-1) in transgenic Caenorhabditis elegans

1992 • 13 citations

A Portable Regulatory Element Directs Specific Expression of the Caenorhabditis elegans Ubiquitin Gene ubq-2 in the Somatic Gonad

1995 • 12 citations

Function of the her‐1 gene is required for maintenance of male differentiation in adult tissues of C. elegans

1994 • 9 citations