Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans

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Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

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The mitogen-activated protein kinase signal transduction pathway

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Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

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Signal transduction via the MAP kinases: proceed at your own RSK.

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Hereditary Anemias of the Mouse: A Review for Geneticists

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The MAP kinase cascade is essential for diverse signal transduction pathways

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Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1988 • 727 citations

glp-1 Is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans

1987 • 684 citations

Oocyte Maturation

1979 • 662 citations

Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function

1991 • 602 citations

The lin-12 locus specifies cell fates in caenorhabditis elegans

1983 • 598 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Development of the reproductive system of Caenorhabditis elegans

1976 • 550 citations

IDENTIFICATION AND CHARACTERIZATION OF 22 GENES THAT AFFECT THE VULVAL CELL LINEAGES OF THE NEMATODE CAENORHABDITIS ELEGANS

1985 • 531 citations

Gonadal expression of c-kit encoded at the W locus of the mouse

1990 • 479 citations

Fertilization and sperm competition in the nematodeCaenorhabditis elegans

1979 • 440 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1990 • 412 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans

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Sequential protein kinase reactions controlling cell growth and differentiation

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A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans

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Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

MAP Kinase Becomes Stably Activated at Metaphase and Is Associated with Microtubule-Organizing Centers during Meiotic Maturation of Mouse Oocytes

1993 • 300 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

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Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions

1991 • 252 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

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A gene involved in the development of the posterior body region of C. elegans

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Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

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Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

1994 • 218 citations

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 • 212 citations

Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.

1993 • 205 citations

Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis

1990 • 198 citations

A template for the protein kinase family

1993 • 196 citations

The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.

1990 • 192 citations

fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans.

1990 • 173 citations

Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.

1991 • 170 citations

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.

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The Expression of c-kit Protein during Oogenesis and Early Embryonic Development1

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Development of the male reproductive system and sexual transformation in the nematode Caenorhabditis elegans

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CROSSOVER SUPPRESSORS AND BALANCED RECESSIVE LETHALS IN CAENORHABDITIS ELEGANS

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The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans.

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Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.

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MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.

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Oculomotor neuroblast migration in the chick embryo in the absence of tecto-tegmental fibers

1979 • 102 citations

The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.

1995 • 95 citations

Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.

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MUTAGENESIS IN CAENORHABDITIS ELEGANS. II. A SPECTRUM OF MUTATIONAL EVENTS INDUCED WITH 1500 R OF γ-RADIATION

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Mutagenesis in Caenorhabditis elegans

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Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans

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Amino Acid Alterations Within a Highly Conserved Region of the Rous Sarcoma Virus src Gene Product pp60^src Inactivate Tyrosine Protein Kinase Activity

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Meiotic pairing behavior of two free duplications of linkage group I in Caenorhabditis elegans

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Formaldehyde mutagenesis in the nematode Caenorhabditis elegans

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MAP Kinase Pathways: Straight and narrow or tortuous and intersecting?

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L'�volution des structures nucl�aires dans l'ovogen�se de Caenorhabditis elegans Maupas 1900

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Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity.

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Cell fate patterning during C. elegans vulval development

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Role of arafproto-oncogene duringCaenorhabditis elegansvulval development

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The role of cell-cell interactions in postembryonic development of the Caenorhabditis elegans germ line

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Analysis of chromosome I rearrangements in Caenorhabditis elegans

1990 • 7 citations