Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination.

Basic local alignment search tool

1990 • 87,358 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Basic Local Alignment Search Tool

1990 • 12,947 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

C. elegans: des neurones et des gènes

2003 • 3,047 citations

Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles

1983 • 1,256 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

NONDISJUNCTION MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1979 • 768 citations

EGG-LAYING DEFECTIVE MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1983 • 730 citations

Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor δ Chain

1989 • 640 citations

A trans-spliced leader sequence on actin mRNA in C. elegans

1987 • 639 citations

A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

1990 • 618 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

POLYPROTEIN GENE EXPRESSION: Generation of Diversity of Neuroendocrine Peptides

1984 • 497 citations

A genetic mapping system in Caenorhabditis elegans based on polymorphic sequence-tagged sites.

1992 • 487 citations

Integrative transformation of Caenorhabditis elegans

1986 • 417 citations

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1989 • 416 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: cDNA cloning, purification, and anti-mitogenic activity

1989 • 321 citations

Cellular interactions in early C. elegans embryos

1987 • 305 citations

Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans.

1992 • 302 citations

AUTOREGULATORY FUNCTIONING OF A DROSOPHILA GENE PRODUCT THAT ESTABLISHES AND MAINTAINS THE SEXUALLY DETERMINED STATE

1984 • 269 citations

MUTATIONS CAUSING TRANSFORMATION OF SEXUAL PHENOTYPE IN THE NEMATODE CAENORHABDITIS ELEGANS

1977 • 253 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

Cell autonomy of lin-12 function in a cell fate decision in C. elegans

1989 • 241 citations

Molecular analysis of the C. elegans sex-determining gene tra-1: A gene encoding two zinc finger proteins

1992 • 233 citations

A mutant affecting the heavy chain of myosin in Caenorhabditis elegans

1974 • 221 citations

CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis

1990 • 216 citations

Termination-reinitiation occurs in the translation of mammalian cell mRNAs.

1986 • 213 citations

POLYPLOIDS AND SEX DETERMINATION IN CAENORHABDITIS ELEGANS

1979 • 194 citations

The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions

1990 • 176 citations

MORE SEX-DETERMINATION MUTANTS OF CAENORHABDITIS ELEGANS

1980 • 166 citations

Evidence from reversal of handedness in C. elegans embryos for early cell interactions determining cell fates

1991 • 166 citations

Sex determination compared in Drosophila and Caenorhabditis

1990 • 165 citations

xol-1: A gene that controls the male modes of both sex determination and X chromosome dosage compensation in C. elegans

1988 • 163 citations

Presence of the Caenorhabditis elegans spliced leader on different mRNAs and in different genera of nematodes.

1988 • 142 citations

Specification of male development in Caenorhabditis elegans: The fem genes

1984 • 131 citations

tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.

1992 • 127 citations

ACTIVITY OF THE SEX-DETERMINING GENE tra-2 IS MODULATED TO ALLOW SPERMATOGENESIS IN THE C. ELEGANS HERMAPHRODITE

1986 • 113 citations

The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally.

1992 • 96 citations

Wild-type and mutant actin genes in Caenorhabditis elegans

1989 • 86 citations

The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals.

1989 • 86 citations

Environmental Sex Differentiation of Nematodes in Relation to Pest Management

1973 • 85 citations

Evidence from mosaic analysis of the masculinizing gene her–1for cell interactions inC. eleganssex determination

1992 • 81 citations

sdc-1: A link between sex determination and dosage compensation in C. elegans

1987 • 80 citations

SEX DETERMINATION AND DOSAGE COMPENSATION IN CAENORHABDITIS ELEGANS

1987 • 80 citations

Sex-specific transcriptional regulation of the C. elegans sex-determining gene her-1

1991 • 80 citations

Early C. elegans embryos are transcriptionally active

1990 • 69 citations

The tra-1 gene determines sexual phenotype cell-autonomously in C. elegans

1990 • 67 citations

Molecular genetics of sex determination in C. elegans

1992 • 66 citations

Molecular analysis of tra-2, a sex determining gene in C.elegans.

1991 • 65 citations

Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans

1990 • 63 citations

9 Sexual Dimorphism and Sex Determination

1988 • 52 citations

UbiA, the Major Polyubiquitin Locus in Caenorhabditis elegans, Has Unusual Structural Features and Is Constitutively Expressed

1989 • 49 citations

A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans.

1988 • 46 citations

Cellular interactions involved in the determination of the early C. elegans embryo

1991 • 45 citations

GENETIC ANALYSIS OF SIZE-SCALING PATTERNS IN THE MOUSE MANDIBLE

1985 • 38 citations

An X-autosome fusion chromosome of Caenorhabditis elegans

1986 • 31 citations

The complex relationship between cell division and the control of differentiation in oligodendrocyte-type-2 astrocyte progenitor cells isolated from perinatal and adult rat optic nerves

1989 • 28 citations

Plasmid vectors for positive galactose-resistance selection of cloned DNA in Escherichia coli

1984 • 26 citations

Use of transposon-promoted deletions in DNA sequence analysis

1984 • 25 citations

Recombinant Human Mullerian Inhibiting Substance Inhibits Epidermal Growth Factor Receptor Tyrosine Kinase

1989 • 24 citations