Bcl-xL antagonism of BCR-coupled mitochondrial phospholipase A2 signaling correlates with protection from apoptosis in WEHI-231 B cells

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Four deaths and a funeral: from caspases to alternative mechanisms

2001 • 1,605 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1999 • 659 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Phosphorylation of Glycogen Synthase Kinase-3 and Stimulation of T-cell Factor Signaling following Activation of EP2 and EP4 Prostanoid Receptors by Prostaglandin E2

2002 • 314 citations

Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases

2003 • 306 citations

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

1997 • 287 citations

Sphingosine‐1‐phosphate: signaling inside and out

2000 • 275 citations

Oxidant, Mitochondria and Calcium

1999 • 269 citations

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

1994 • 262 citations

Apoptosis without caspases: an inefficient molecular guillotine?

1999 • 247 citations

Arachidonic Acid in Platelet Microparticles Up-regulates Cyclooxygenase-2-dependent Prostaglandin Formation via a Protein Kinase C/Mitogen-activated Protein Kinase-dependent Pathway

1999 • 240 citations

Apoptosis signaling in lymphocytes

1999 • 212 citations

Triggering of apoptosis by cathepsins

2001 • 204 citations

Secretory Phospholipase A2

2004 • 202 citations

Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes

1998 • 196 citations

Implication of calpain in caspase activation during B cell clonal deletion

1999 • 178 citations

ATP-dependent steps in apoptotic signal transduction.

1999 • 169 citations

Secretory Phospholipase A2 Activates the Cascade of Mitogen-activated Protein Kinases and Cytosolic Phospholipase A2 in the Human Astrocytoma Cell Line 1321N1

1998 • 158 citations

The role of bcl‐x_L in CD40‐mediated rescue from anti‐μ‐induced apoptosis in WEHI‐231 B lymphoma cells

1995 • 154 citations

Selection events operating at various stages in B cell development

2001 • 133 citations

Ceramide Mediates the Apoptotic Response of WEHI 231 Cells to Anti-immunoglobulin, Corticosteroids and Irradiation

1994 • 129 citations

Unbalanced Expression of Bcl-2 Family Proteins in Follicular Lymphoma: Contribution of CD40 Signaling in Promoting Survival

1998 • 126 citations

Anti-immunoglobulin-induced Apoptosis in WEHI 231 Cells Involves the Slow Formation of Ceramide from Sphingomyelin and Is Blocked by bcl-xL

1997 • 114 citations

Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40 in WEHI-231 cells. Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction.

1995 • 114 citations

CD40 signaling-mediated induction of Bcl-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth.

1995 • 101 citations

Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization.

1993 • 94 citations

Prostaglandin E2 induces apoptosis in immature normal and malignant B lymphocytes

1992 • 85 citations

Prostaglandin E2 and cAMP inhibit B lymphocyte activation and simultaneously promote IgE and IgG1 synthesis.

1992 • 82 citations

A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death

1999 • 82 citations

Regulatory effects of prostaglandin E2 on the growth and differentiation of human B lymphocytes activated through their CD40 antigen.

1994 • 69 citations

Inhibition of Phosphatidylinositol 3-Kinase Sensitizes Vascular Endothelial Cells to Cytokine-initiated Cathepsin-dependent Apoptosis

2003 • 66 citations

Lack of Release of Cytochrome c from Mitochondria into Cytosol Early in the Course of Fas-mediated Apoptosis of Jurkat Cells

1998 • 66 citations

Reversal of EBV Immortalization Precedes Apoptosis in IL-6–Induced Human B Cell Terminal Differentiation

1997 • 61 citations

Up-Regulation of Bcl-xLExpression Protects CD40-Activated Human B Cells from Fas-Mediated Apoptosis

1996 • 60 citations

B Cell Receptor-Stimulated Mitochondrial Phospholipase A2 Activation and Resultant Disruption of Mitochondrial Membrane Potential Correlate with the Induction of Apoptosis in WEHI-231 B Cells

2001 • 59 citations

Cytochrome c Induces Caspase-Dependent Apoptosis in Intact Hematopoietic Cells and Overrides Apoptosis Suppression Mediated by bcl-2, Growth Factor Signaling, MAP-Kinase-Kinase, and Malignant Change

1998 • 55 citations

Activation of phospholipase A2 in human neutrophils by polyunsaturated fatty acids and its role in stimulation of superoxide production

1998 • 53 citations

Regulation of thymocyte proliferative response by macrophage‐derived prostaglandin E₂ and inter leukin 1

1985 • 52 citations

Mitochondria-Dependent Caspase-9 Activation Is Necessary for Antigen Receptor-Mediated Effector Caspase Activation and Apoptosis in WEHI 231 Lymphoma Cells

2002 • 49 citations

Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation.

1996 • 49 citations

The CD40-Inducible Bcl-2 Family Member A1 Protects B Cells from Antigen Receptor-Mediated Apoptosis

2000 • 49 citations

Differential Roles for Extracellularly Regulated Kinase-Mitogen-Activated Protein Kinase in B Cell Antigen Receptor-Induced Apoptosis and CD40-Mediated Rescue of WEHI-231 Immature B Cells

2002 • 47 citations

Death signals from the B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascades in a murine B cell line, WEHI-231

1999 • 47 citations

Resistance to anti‐IgM‐induced apoptosis in a WEHI‐231 subline is due to insufficient production of ceramide

1995 • 41 citations

Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells

1998 • 36 citations

Prostaglandin E₂biphasic control of lymphocyte proliferation: inhibition by picomolar concentrations

1997 • 32 citations

Lymphocyte signalling : mechanisms, subversion, and manipulation

1997 • 24 citations

Antagonistic Roles for Phospholipase D Activities in B Cell Signaling: While the Antigen Receptors Transduce Mitogenic Signals Via a Novel Phospholipase D Activity, Phosphatidylcholine-Phospholipase D Mediates Antiproliferative Signals

1998 • 24 citations

Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats

2001 • 11 citations

Molecular mechanisms regulating B-cell negative selection

1997 • 10 citations

Cyclic nucleotide signalling throughout T cell maturation

1997 • 3 citations