The Impact of CYP2C19 and CYP2D6 Genotypes on Metabolism of Amitriptyline in Japanese Psychiatric Patients

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

1994 • 749 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1994 • 429 citations

Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines

2000 • 422 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

1998 • 284 citations

PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSE

1972 • 263 citations

Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology

1995 • 243 citations

Tricyclic antidepressants--blood level measurements and clinical outcome: an APA Task Force report. Task Force on the Use of Laboratory Tests in Psychiatry

1985 • 202 citations

Amitriptyline plasma levels and therapeutic response

1976 • 194 citations

E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation

1981 • 171 citations

Five Distinct Human Cytochromes Mediate Amitriptyline N‐Demethylation In Vitro: Dominance of CYP 2C19 and 3A4

1998 • 156 citations

Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression

1979 • 142 citations

Analysis of the gene in relation to dextromethorphan -demethylation capacity in a Japanese population

1999 • 117 citations

Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man

1980 • 111 citations

Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.

2001 • 100 citations

Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6.

1999 • 93 citations

Amitriptyline plasma levels and clinical response in primary depression

1977 • 93 citations

Nortriptyline E‐10‐Hydroxylation in Vitro Is Mediated by Human CYP2D6 (High Affinity) and CYP3A4 (Low Affinity): Implications for Interactions with Enzyme‐Inducing Drugs

1999 • 92 citations

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

1992 • 89 citations

N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.

1995 • 89 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes.

1997 • 81 citations

Metabolism of the Tricyclic Antidepressant Amitriptyline by cDNA-Expressed Human Cytochrome P450 Enzymes

1997 • 76 citations

Cytochromes P450 mediating the N‐demethylation of amitriptyline

1997 • 72 citations

Plasma concentrations of nortriptyline and its 10‐hydroxy metabolite in depressed patients‐relationship to the debrisoquine hydroxylation metabolic ratio.

1985 • 69 citations

Clinical response and plasma concentration of amitriptyline and its metabolite nortriptyline

1978 • 66 citations

Amitriptyline plasma concentration and clinical response.

1979 • 60 citations

Steady-State Plasma Levels of Nortriptyline and Its Hydroxylated Metabolites in Japanese Patients: Impact of CYP2D6 Genotype on the Hydroxylation of Nortriptyline

2000 • 60 citations

Reversed-phase liquid chromatography for the separation of chlorpromazine, imipramine and some of their metabolites

1981 • 59 citations

Relative Contribution of CYP3A to Amitriptyline Clearance in Humans: In Vitro and In Vivo Studies

2001 • 59 citations

Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level

1972 • 49 citations

Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline <scp>N</scp>‐demethylation

1996 • 46 citations

The Effect of CYP2C19 and CYP2D6 Genotypes on the Metabolism of Clomipramine in Japanese Psychiatric Patients

2001 • 40 citations

Phenobarbital Induces the 2-Hydroxylation of Desipramine

1996 • 28 citations

Pronounced Differences in the Disposition of Clomipramine Between Japanese and Swedish Patients

1999 • 28 citations

Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects

1984 • 26 citations

The effect of neuroleptics on imipramine demethylation in rat liver microsomes and imipramine and desipramine level in the rat brain

1986 • 24 citations

Metabolism of amitriptyline with CYP2D6 expressed in a human cell line

1997 • 24 citations

Stereoselective inhibition of nortriptyline hydroxylation in man by quinidine

1992 • 20 citations

No Interaction of Diazepam on Amitriptyline Disposition in Depressed Patients

1987 • 17 citations

Significance of monitoring plasma levels of amitriptyline, and its hydroxylated and desmethylated metabolites in prediction of the clinical outcome of depressive state

1997 • 15 citations

Alprazolam Does Not Inhibit the Metabolism of Nortriptyline in Depressed Patients of Inhibit the Metabolism of Desipramine in Human Liver Microsomes

1988 • 14 citations

Interindividual Variations of Desmethylation and Hydroxylation of Amitriptyline in a Japanese Psychiatric Population

1995 • 11 citations

Influence of neuroleptics on the metabolism of tricyclic antidepressants—in vitro experiments with rat liver microsomes

1986 • 11 citations