10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 • 647 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Nomenclature for human CYP2D6 alleles

1996 • 406 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

MEDICAL NEMESIS

1974 • 377 citations

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.

1996 • 373 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles ofCYP2D6in a European Population

1991 • 224 citations

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1992 • 190 citations

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population*

1995 • 187 citations

E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation

1981 • 171 citations

Extremely Rapid Hydroxylation of Debrisoquine

1985 • 144 citations

Polymorphic Drug Oxidation

1996 • 141 citations

A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin

1985 • 127 citations

Quick Onset of Severe Abdominal Pain After Codeine in an Ultrarapid Metabolizer of Debrisoquine

1997 • 124 citations

Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline

1979 • 106 citations

SI UNITS

1975 • 101 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

Plasma concentrations of nortriptyline and its 10‐hydroxy metabolite in depressed patients‐relationship to the debrisoquine hydroxylation metabolic ratio.

1985 • 69 citations

Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level

1972 • 49 citations

Circulatory effects in man of nortriptyline, a tricyclic antidepressant drug

1970 • 46 citations

Enantioselective Hydroxylation of Nortriptyline in Human Liver Microsomes, Intestinal Homogenate, and Patients Treated with Nortriptyline

1991 • 37 citations

Stereoselective disposition of racemic E-10-hydroxynortriptyline in human beings

1989 • 34 citations

Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects

1986 • 32 citations

Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors

1984 • 17 citations

Little anticholinergic effect of E-10-hydroxynortriptyline compared with nortriptyline in healthy subjects

1987 • 17 citations

Assessment of the relationship between plasma nortriptyline concentration and inhibition of salivation: Single-dose study

1991 • 2 citations