Relative Contribution of CYP3A to Amitriptyline Clearance in Humans: In Vitro and In Vivo Studies

CYTOCHROME P-450 3A4: Regulation and Role in Drug Metabolism

1999 • 1,235 citations

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1994 • 865 citations

Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

1997 • 755 citations

Terfenadine-Ketoconazole Interaction

1993 • 654 citations

Effects of the Antifungal Agents on Oxidative Drug Metabolism

2000 • 506 citations

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

1994 • 407 citations

In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model.

2000 • 388 citations

Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4

1997 • 380 citations

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

1994 • 275 citations

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole.

1996 • 220 citations

Disposition of ketoconazole, an oral antifungal, in humans

1982 • 205 citations

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

2000 • 191 citations

Five Distinct Human Cytochromes Mediate Amitriptyline N‐Demethylation In Vitro: Dominance of CYP 2C19 and 3A4

1998 • 156 citations

Xenobiotic-metabolizing human cells as tools for pharmacological and toxicological research

1995 • 149 citations

The use of heterologously expressed drug metabolizing enzymes— state of the art and prospects for the future

1999 • 145 citations

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

1993 • 143 citations

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

1999 • 129 citations

Use of cDNA-Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions

1997 • 125 citations

Ketoconazole inhibition of triazolam and alprazolam clearance: Differential kinetic and dynamic consequences*

1998 • 120 citations

Metabolism of Drugs by Cytochrome P450 3A Isoforms

1995 • 120 citations

Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.

2001 • 100 citations

Reconstitution Premixes for Assays Using Purified Recombinant Human Cytochrome P450, NADPH-Cytochrome P450 Reductase, and Cytochromeb5

1997 • 90 citations

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

1992 • 89 citations

N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.

1995 • 89 citations

Pharmacokinetic-Pharmacodynamic Relationships For Benzodiazepines

1996 • 89 citations

Effect of ketoconazole on hepatic oxidative drug metabolism

1985 • 86 citations

Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin*

1997 • 83 citations

Amitriptyline metabolism: Association with debrisoquin hydroxylation in nonsmokers

1986 • 82 citations

Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole*

1998 • 80 citations

Metabolism of the Tricyclic Antidepressant Amitriptyline by cDNA-Expressed Human Cytochrome P450 Enzymes

1997 • 76 citations

Amitriptyline metabolism: Relationship to polymorphic debrisoquine hydroxylation

1983 • 70 citations

Discrepancies Between Pharmacokinetic Studies of Amitriptyline

1985 • 68 citations

Quantitative prediction of metabolic inhibition of midazolam by itraconazole and ketoconazole in rats: implication of concentrative uptake of inhibitors into liver.

1999 • 63 citations

Contrasting effects of fluconazole and ketoconazole on phenytoin and testosterone disposition in man.

1992 • 57 citations

Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: Kinetic-dynamic studies

1994 • 57 citations

Interindividual differences in amitriptyline demethylation

1980 • 55 citations

Pharmacokinetics and Pharmacodynamics of Diphenhydramine 25 mg in Young and Elderly Volunteers

1998 • 49 citations

Sedative effects and impaired learning and recall after single oral doses of lorazepam

1986 • 48 citations

Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline <scp>N</scp>‐demethylation

1996 • 46 citations

GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin

1988 • 44 citations

Predicting Drug Interactions In Vivo from Experiments In Vitro

1997 • 44 citations

Biotransformation of amitriptyline in depressive patients: Urinary excretion of seven metabolites

1982 • 38 citations

Pre-stimulus/post-stimulus relations in EEG spectra and their modulations by an opioid and an antidepressant

1989 • 38 citations

Determination of ketoconazole in the plasma, liver, lung and adrenal of the rat by high-performance liquid chromatography

1986 • 38 citations

The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

1996 • 37 citations

Effect of ketoconazole on the pharmacokinetics of imipramine and desipramine in healthy subjects

1997 • 36 citations

Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers

1989 • 33 citations

The effect of ketoconazole on the pharmacokinetics, pharmacodynamics and safety of nisoldipine

1999 • 32 citations

Disposition of azole antifungal agents. I. Nonlinearities in ketoconazole clearance and binding in rat liver.

1993 • 32 citations

Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice.

1998 • 31 citations

Tricyclic Antidepressant Determination in Human Plasma by Gas-Liquid Chromatography Using Nitrogen-Phosphorous Detection: Application to Single-Dose Pharmacokinetic Studies

1981 • 22 citations

Effect of Chronically Administered Ketoconazole on the Elimination of Theophylline in Man

1987 • 17 citations

Ketoconazole does not effect the systemic conversion of losartan to E-3174.

1996 • 17 citations

[11] In vivo and in vitro measurement of CYP2C19 activity

1996 • 12 citations

Electrophysiologic Analysis of Antidepressant Drug Effects on the GABA&lt;sub&gt;A&lt;/sub&gt; Receptor Complex Based upon Antagonist-Induced Encephalographic Power Spectrum Changes

2000 • 11 citations

Urinary metabolites of amitriptylinoxide and amitriptyline in single-dose experiments and during continuous therapy

1992 • 9 citations

Quantitative Pharmaco-electroencephalographic Differentiation between the CNS Effects of Bromocriptine and Imipramine, Drugs with Qualitatively Different Antidepressant Properties

1987 • 8 citations